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Items: 1 to 20 of 52

1.

Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.

Ng CH, Mok SZ, Koh C, Ouyang X, Fivaz ML, Tan EK, Dawson VL, Dawson TM, Yu F, Lim KL.

J Neurosci. 2009 Sep 9;29(36):11257-62. doi: 10.1523/JNEUROSCI.2375-09.2009.

2.

R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.

Tong Y, Pisani A, Martella G, Karouani M, Yamaguchi H, Pothos EN, Shen J.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14622-7. doi: 10.1073/pnas.0906334106. Epub 2009 Aug 10.

3.

Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions.

Greggio E, Cookson MR.

ASN Neuro. 2009 Apr 14;1(1). pii: e00002. doi: 10.1042/AN20090007. Review.

4.

Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease.

Li Y, Liu W, Oo TF, Wang L, Tang Y, Jackson-Lewis V, Zhou C, Geghman K, Bogdanov M, Przedborski S, Beal MF, Burke RE, Li C.

Nat Neurosci. 2009 Jul;12(7):826-8. doi: 10.1038/nn.2349. Epub 2009 Jun 7.

5.

Mobilization of calcium from intracellular stores facilitates somatodendritic dopamine release.

Patel JC, Witkovsky P, Avshalumov MV, Rice ME.

J Neurosci. 2009 May 20;29(20):6568-79. doi: 10.1523/JNEUROSCI.0181-09.2009.

6.

Progression of dopaminergic dysfunction in a LRRK2 kindred: a multitracer PET study.

Nandhagopal R, Mak E, Schulzer M, McKenzie J, McCormick S, Sossi V, Ruth TJ, Strongosky A, Farrer MJ, Wszolek ZK, Stoessl AJ.

Neurology. 2008 Nov 25;71(22):1790-5. doi: 10.1212/01.wnl.0000335973.66333.58.

7.

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila.

Imai Y, Gehrke S, Wang HQ, Takahashi R, Hasegawa K, Oota E, Lu B.

EMBO J. 2008 Sep 17;27(18):2432-43. doi: 10.1038/emboj.2008.163. Epub 2008 Aug 14.

8.

AMPA receptor-dependent H2O2 generation in striatal medium spiny neurons but not dopamine axons: one source of a retrograde signal that can inhibit dopamine release.

Avshalumov MV, Patel JC, Rice ME.

J Neurophysiol. 2008 Sep;100(3):1590-601. doi: 10.1152/jn.90548.2008. Epub 2008 Jul 16.

9.

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study.

Healy DG, Falchi M, O'Sullivan SS, Bonifati V, Durr A, Bressman S, Brice A, Aasly J, Zabetian CP, Goldwurm S, Ferreira JJ, Tolosa E, Kay DM, Klein C, Williams DR, Marras C, Lang AE, Wszolek ZK, Berciano J, Schapira AH, Lynch T, Bhatia KP, Gasser T, Lees AJ, Wood NW; International LRRK2 Consortium.

Lancet Neurol. 2008 Jul;7(7):583-90. doi: 10.1016/S1474-4422(08)70117-0. Epub 2008 Jun 6.

10.

Investigating convergent actions of genes linked to familial Parkinson's disease.

Wolozin B, Saha S, Guillily M, Ferree A, Riley M.

Neurodegener Dis. 2008;5(3-4):182-5. doi: 10.1159/000113697. Epub 2008 Mar 6.

11.

A Drosophila model for LRRK2-linked parkinsonism.

Liu Z, Wang X, Yu Y, Li X, Wang T, Jiang H, Ren Q, Jiao Y, Sawa A, Moran T, Ross CA, Montell C, Smith WW.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2693-8. doi: 10.1073/pnas.0708452105. Epub 2008 Feb 7.

12.

Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons.

Wang D, Tang B, Zhao G, Pan Q, Xia K, Bodmer R, Zhang Z.

Mol Neurodegener. 2008 Feb 8;3:3. doi: 10.1186/1750-1326-3-3.

13.

Transgenic mice overexpressing tyrosine-to-cysteine mutant human alpha-synuclein: a progressive neurodegenerative model of diffuse Lewy body disease.

Zhou W, Milder JB, Freed CR.

J Biol Chem. 2008 Apr 11;283(15):9863-70. doi: 10.1074/jbc.M710232200. Epub 2008 Jan 30.

14.

The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity.

Guo L, Gandhi PN, Wang W, Petersen RB, Wilson-Delfosse AL, Chen SG.

Exp Cell Res. 2007 Oct 1;313(16):3658-70. Epub 2007 Jul 19.

15.

Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants.

Li X, Tan YC, Poulose S, Olanow CW, Huang XY, Yue Z.

J Neurochem. 2007 Oct;103(1):238-47. Epub 2007 Jul 10.

16.

Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice.

Kitada T, Pisani A, Porter DR, Yamaguchi H, Tscherter A, Martella G, Bonsi P, Zhang C, Pothos EN, Shen J.

Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11441-6. Epub 2007 Jun 11.

17.

Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila.

Lee SB, Kim W, Lee S, Chung J.

Biochem Biophys Res Commun. 2007 Jun 29;358(2):534-9. Epub 2007 May 4.

PMID:
17498648
19.

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity.

Jaleel M, Nichols RJ, Deak M, Campbell DG, Gillardon F, Knebel A, Alessi DR.

Biochem J. 2007 Jul 15;405(2):307-17.

20.

LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins.

Sakaguchi-Nakashima A, Meir JY, Jin Y, Matsumoto K, Hisamoto N.

Curr Biol. 2007 Apr 3;17(7):592-8. Epub 2007 Mar 8.

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