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Items: 1 to 20 of 56

1.

Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria.

Yang SH, Chang SY, Andres DA, Spielmann HP, Young SG, Fong LG.

J Lipid Res. 2010 Feb;51(2):400-5. doi: 10.1194/jlr.M002808. Epub 2009 Oct 26.

2.

Laminopathies and the long strange trip from basic cell biology to therapy.

Worman HJ, Fong LG, Muchir A, Young SG.

J Clin Invest. 2009 Jul;119(7):1825-36. doi: 10.1172/JCI37679. Epub 2009 Jul 1. Review.

3.

The posttranslational processing of prelamin A and disease.

Davies BS, Fong LG, Yang SH, Coffinier C, Young SG.

Annu Rev Genomics Hum Genet. 2009;10:153-74. doi: 10.1146/annurev-genom-082908-150150. Review.

4.

The hair follicle as a dynamic miniorgan.

Schneider MR, Schmidt-Ullrich R, Paus R.

Curr Biol. 2009 Feb 10;19(3):R132-42. doi: 10.1016/j.cub.2008.12.005. Review.

5.

Caution! Analyze transcripts from conditional knockout alleles.

Yang SH, Bergo MO, Farber E, Qiao X, Fong LG, Young SG.

Transgenic Res. 2009 Jun;18(3):483-9. doi: 10.1007/s11248-008-9237-9. Epub 2008 Dec 18.

6.

Hair follicle stem cells are specified and function in early skin morphogenesis.

Nowak JA, Polak L, Pasolli HA, Fuchs E.

Cell Stem Cell. 2008 Jul 3;3(1):33-43. doi: 10.1016/j.stem.2008.05.009.

7.

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.

Varela I, Pereira S, Ugalde AP, Navarro CL, Suárez MF, Cau P, Cadiñanos J, Osorio FG, Foray N, Cobo J, de Carlos F, Lévy N, Freije JM, López-Otín C.

Nat Med. 2008 Jul;14(7):767-72. doi: 10.1038/nm1786. Epub 2008 Jun 29.

PMID:
18587406
8.

Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson-Gilford progeria syndrome mutation.

Yang SH, Qiao X, Fong LG, Young SG.

Biochim Biophys Acta. 2008 Jan-Feb;1781(1-2):36-9. Epub 2007 Nov 26.

9.

New approaches to progeria.

Kieran MW, Gordon L, Kleinman M.

Pediatrics. 2007 Oct;120(4):834-41. Review. Erratum in: Pediatrics. 2007 Dec;120(6):1405.

PMID:
17908771
10.

GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer.

Sjogren AK, Andersson KM, Liu M, Cutts BA, Karlsson C, Wahlstrom AM, Dalin M, Weinbaum C, Casey PJ, Tarkowski A, Swolin B, Young SG, Bergo MO.

J Clin Invest. 2007 May;117(5):1294-304.

11.

Towards complete sets of farnesylated and geranylgeranylated proteins.

Maurer-Stroh S, Koranda M, Benetka W, Schneider G, Sirota FL, Eisenhaber F.

PLoS Comput Biol. 2007 Apr 6;3(4):e66. Epub 2007 Feb 23.

12.

Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons.

Beigneux AP, Davies BS, Gin P, Weinstein MM, Farber E, Qiao X, Peale F, Bunting S, Walzem RL, Wong JS, Blaner WS, Ding ZM, Melford K, Wongsiriroj N, Shu X, de Sauvage F, Ryan RO, Fong LG, Bensadoun A, Young SG.

Cell Metab. 2007 Apr;5(4):279-91.

13.

Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells.

Castilho RM, Squarize CH, Patel V, Millar SE, Zheng Y, Molinolo A, Gutkind JS.

Oncogene. 2007 Aug 2;26(35):5078-85. Epub 2007 Mar 5.

PMID:
17334398
14.

A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation.

Yang SH, Meta M, Qiao X, Frost D, Bauch J, Coffinier C, Majumdar S, Bergo MO, Young SG, Fong LG.

J Clin Invest. 2006 Aug;116(8):2115-21.

15.

Using inhibitors of prenylation to block localization and transforming activity.

Berzat AC, Brady DC, Fiordalisi JJ, Cox AD.

Methods Enzymol. 2006;407:575-97.

PMID:
16757354
16.

Prelamin A and lamin A appear to be dispensable in the nuclear lamina.

Fong LG, Ng JK, Lammerding J, Vickers TA, Meta M, Coté N, Gavino B, Qiao X, Chang SY, Young SR, Yang SH, Stewart CL, Lee RT, Bennett CF, Bergo MO, Young SG.

J Clin Invest. 2006 Mar;116(3):743-52.

17.

A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria.

Fong LG, Frost D, Meta M, Qiao X, Yang SH, Coffinier C, Young SG.

Science. 2006 Mar 17;311(5767):1621-3. Epub 2006 Feb 16.

18.

Homozygous and compound heterozygous mutations in ZMPSTE24 cause the laminopathy restrictive dermopathy.

Moulson CL, Go G, Gardner JM, van der Wal AC, Smitt JH, van Hagen JM, Miner JH.

J Invest Dermatol. 2005 Nov;125(5):913-9.

19.
20.

Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes.

Toth JI, Yang SH, Qiao X, Beigneux AP, Gelb MH, Moulson CL, Miner JH, Young SG, Fong LG.

Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12873-8. Epub 2005 Aug 29.

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