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References for PMC Articles for PubMed (Select 19933331)


Cyclodipeptide synthases are a family of tRNA-dependent peptide bond-forming enzymes.

Gondry M, Sauguet L, Belin P, Thai R, Amouroux R, Tellier C, Tuphile K, Jacquet M, Braud S, Courçon M, Masson C, Dubois S, Lautru S, Lecoq A, Hashimoto S, Genet R, Pernodet JL.

Nat Chem Biol. 2009 Jun;5(6):414-20. doi: 10.1038/nchembio.175.


Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis.

Belin P, Le Du MH, Fielding A, Lequin O, Jacquet M, Charbonnier JB, Lecoq A, Thai R, Courçon M, Masson C, Dugave C, Genet R, Pernodet JL, Gondry M.

Proc Natl Acad Sci U S A. 2009 May 5;106(18):7426-31. doi: 10.1073/pnas.0812191106. Epub 2009 Apr 22.


Menaquinone synthesis is critical for maintaining mycobacterial viability during exponential growth and recovery from non-replicating persistence.

Dhiman RK, Mahapatra S, Slayden RA, Boyne ME, Lenaerts A, Hinshaw JC, Angala SK, Chatterjee D, Biswas K, Narayanasamy P, Kurosu M, Crick DC.

Mol Microbiol. 2009 Apr;72(1):85-97. doi: 10.1111/j.1365-2958.2009.06625.x. Epub 2009 Feb 11.


Cooperative effects on radical recombination in CYP3A4-catalyzed oxidation of the radical clock beta-thujone.

Jiang Y, Ortiz de Montellano PR.

Chembiochem. 2009 Mar 2;10(4):650-3. doi: 10.1002/cbic.200800772.


Reaction of Mycobacterium tuberculosis cytochrome P450 enzymes with nitric oxide.

Ouellet H, Lang J, Couture M, Ortiz de Montellano PR.

Biochemistry. 2009 Feb 10;48(5):863-72. doi: 10.1021/bi801595t.


Structural characterization of a novel sulfated menaquinone produced by stf3 from Mycobacterium tuberculosis.

Holsclaw CM, Sogi KM, Gilmore SA, Schelle MW, Leavell MD, Bertozzi CR, Leary JA.

ACS Chem Biol. 2008 Oct 17;3(10):619-24. doi: 10.1021/cb800145r.


Genomic-scale prioritization of drug targets: the TDR Targets database.

Agüero F, Al-Lazikani B, Aslett M, Berriman M, Buckner FS, Campbell RK, Carmona S, Carruthers IM, Chan AW, Chen F, Crowther GJ, Doyle MA, Hertz-Fowler C, Hopkins AL, McAllister G, Nwaka S, Overington JP, Pain A, Paolini GV, Pieper U, Ralph SA, Riechers A, Roos DS, Sali A, Shanmugam D, Suzuki T, Van Voorhis WC, Verlinde CL.

Nat Rev Drug Discov. 2008 Nov;7(11):900-7. doi: 10.1038/nrd2684. Epub 2008 Oct 17.


Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv.

McLean KJ, Carroll P, Lewis DG, Dunford AJ, Seward HE, Neeli R, Cheesman MR, Marsollier L, Douglas P, Smith WE, Rosenkrands I, Cole ST, Leys D, Parish T, Munro AW.

J Biol Chem. 2008 Nov 28;283(48):33406-16. doi: 10.1074/jbc.M802115200. Epub 2008 Sep 24.


Structural biology and biochemistry of cytochrome P450 systems in Mycobacterium tuberculosis.

McLean KJ, Munro AW.

Drug Metab Rev. 2008;40(3):427-46. doi: 10.1080/03602530802186389 . Review.


How do azoles inhibit cytochrome P450 enzymes? A density functional study.

Balding PR, Porro CS, McLean KJ, Sutcliffe MJ, Maréchal JD, Munro AW, de Visser SP.

J Phys Chem A. 2008 Dec 18;112(50):12911-8. doi: 10.1021/jp802087w.


Mycobacterial persistence requires the utilization of host cholesterol.

Pandey AK, Sassetti CM.

Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4376-80. doi: 10.1073/pnas.0711159105. Epub 2008 Mar 11. Erratum in: Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9130.


Mycobacterium tuberculosis CYP130: crystal structure, biophysical characterization, and interactions with antifungal azole drugs.

Ouellet H, Podust LM, de Montellano PR.

J Biol Chem. 2008 Feb 22;283(8):5069-80. Epub 2007 Dec 18.


PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1.

Kumar P, Schelle MW, Jain M, Lin FL, Petzold CJ, Leavell MD, Leary JA, Cox JS, Bertozzi CR.

Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11221-6. Epub 2007 Jun 25.


Structure, function and drug targeting in Mycobacterium tuberculosis cytochrome P450 systems.

McLean KJ, Dunford AJ, Neeli R, Driscoll MD, Munro AW.

Arch Biochem Biophys. 2007 Aug 15;464(2):228-40. Epub 2007 Apr 10. Review.


Versatile polyketide enzymatic machinery for the biosynthesis of complex mycobacterial lipids.

Gokhale RS, Saxena P, Chopra T, Mohanty D.

Nat Prod Rep. 2007 Apr;24(2):267-77. Epub 2007 Feb 28. Review.


A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages.

Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, Anderton MC, Sim E, Dijkhuizen L, Davies JE, Mohn WW, Eltis LD.

Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1947-52. Epub 2007 Jan 30.


Prediction of activation energies for hydrogen abstraction by cytochrome p450.

Olsen L, Rydberg P, Rod TH, Ryde U.

J Med Chem. 2006 Nov 2;49(22):6489-99.


Crystal structure of the Mycobacterium tuberculosis P450 CYP121-fluconazole complex reveals new azole drug-P450 binding mode.

Seward HE, Roujeinikova A, McLean KJ, Munro AW, Leys D.

J Biol Chem. 2006 Dec 22;281(51):39437-43. Epub 2006 Oct 6.


Biophysical characterization of the sterol demethylase P450 from Mycobacterium tuberculosis, its cognate ferredoxin, and their interactions.

McLean KJ, Warman AJ, Seward HE, Marshall KR, Girvan HM, Cheesman MR, Waterman MR, Munro AW.

Biochemistry. 2006 Jul 11;45(27):8427-43.

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