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Results: 1 to 20 of 52

1.

The VDAC2-BAK rheostat controls thymocyte survival.

Ren D, Kim H, Tu HC, Westergard TD, Fisher JK, Rubens JA, Korsmeyer SJ, Hsieh JJ, Cheng EH.

Sci Signal. 2009 Aug 25;2(85):ra48. doi: 10.1126/scisignal.2000274.

PMID:
19706873
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Mitochondrial outer membrane proteins assist Bid in Bax-mediated lipidic pore formation.

Schafer B, Quispe J, Choudhary V, Chipuk JE, Ajero TG, Du H, Schneiter R, Kuwana T.

Mol Biol Cell. 2009 Apr;20(8):2276-85. doi: 10.1091/mbc.E08-10-1056. Epub 2009 Feb 25.

PMID:
19244344
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax.

Lovell JF, Billen LP, Bindner S, Shamas-Din A, Fradin C, Leber B, Andrews DW.

Cell. 2008 Dec 12;135(6):1074-84. doi: 10.1016/j.cell.2008.11.010.

PMID:
19062087
[PubMed - indexed for MEDLINE]
Free Article
4.

BAX activation is initiated at a novel interaction site.

Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng EH, Tjandra N, Walensky LD.

Nature. 2008 Oct 23;455(7216):1076-81. doi: 10.1038/nature07396.

PMID:
18948948
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

Dewson G, Kratina T, Sim HW, Puthalakath H, Adams JM, Colman PM, Kluck RM.

Mol Cell. 2008 May 9;30(3):369-80. doi: 10.1016/j.molcel.2008.04.005.

PMID:
18471982
[PubMed - indexed for MEDLINE]
Free Article
6.

Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress.

Upton JP, Austgen K, Nishino M, Coakley KM, Hagen A, Han D, Papa FR, Oakes SA.

Mol Cell Biol. 2008 Jun;28(12):3943-51. doi: 10.1128/MCB.00013-08. Epub 2008 Apr 21.

PMID:
18426910
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

Chipuk JE, Green DR.

Trends Cell Biol. 2008 Apr;18(4):157-64. doi: 10.1016/j.tcb.2008.01.007. Epub 2008 Mar 7. Review.

PMID:
18314333
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

The BCL-2 protein family: opposing activities that mediate cell death.

Youle RJ, Strasser A.

Nat Rev Mol Cell Biol. 2008 Jan;9(1):47-59. Review.

PMID:
18097445
[PubMed - indexed for MEDLINE]
9.

A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax.

George NM, Evans JJ, Luo X.

Genes Dev. 2007 Aug 1;21(15):1937-48.

PMID:
17671092
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

ER stress triggers apoptosis by activating BH3-only protein Bim.

Puthalakath H, O'Reilly LA, Gunn P, Lee L, Kelly PN, Huntington ND, Hughes PD, Michalak EM, McKimm-Breschkin J, Motoyama N, Gotoh T, Akira S, Bouillet P, Strasser A.

Cell. 2007 Jun 29;129(7):1337-49.

PMID:
17604722
[PubMed - indexed for MEDLINE]
Free Article
11.

Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes.

Leber B, Lin J, Andrews DW.

Apoptosis. 2007 May;12(5):897-911. Review.

PMID:
17453159
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.

Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE, Ierino H, Lee EF, Fairlie WD, Bouillet P, Strasser A, Kluck RM, Adams JM, Huang DC.

Science. 2007 Feb 9;315(5813):856-9.

PMID:
17289999
[PubMed - indexed for MEDLINE]
Free Article
13.

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies.

Kim H, Rafiuddin-Shah M, Tu HC, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH.

Nat Cell Biol. 2006 Dec;8(12):1348-58. Epub 2006 Nov 19.

PMID:
17115033
[PubMed - indexed for MEDLINE]
14.

A stapled BID BH3 helix directly binds and activates BAX.

Walensky LD, Pitter K, Morash J, Oh KJ, Barbuto S, Fisher J, Smith E, Verdine GL, Korsmeyer SJ.

Mol Cell. 2006 Oct 20;24(2):199-210.

PMID:
17052454
[PubMed - indexed for MEDLINE]
Free Article
15.

BCL-2 in the crosshairs: tipping the balance of life and death.

Walensky LD.

Cell Death Differ. 2006 Aug;13(8):1339-50. Epub 2006 Jun 9. Review.

PMID:
16763614
[PubMed - indexed for MEDLINE]
Free Article
16.

Proapoptotic multidomain Bcl-2/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities.

Reed JC.

Cell Death Differ. 2006 Aug;13(8):1378-86. Epub 2006 Jun 2. Review.

PMID:
16729025
[PubMed - indexed for MEDLINE]
Free Article
17.

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members.

Certo M, Del Gaizo Moore V, Nishino M, Wei G, Korsmeyer S, Armstrong SA, Letai A.

Cancer Cell. 2006 May;9(5):351-65.

PMID:
16697956
[PubMed - indexed for MEDLINE]
Free Article
18.

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly.

Kuwana T, Bouchier-Hayes L, Chipuk JE, Bonzon C, Sullivan BA, Green DR, Newmeyer DD.

Mol Cell. 2005 Feb 18;17(4):525-35.

PMID:
15721256
[PubMed - indexed for MEDLINE]
Free Article
19.

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum.

Oakes SA, Scorrano L, Opferman JT, Bassik MC, Nishino M, Pozzan T, Korsmeyer SJ.

Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):105-10. Epub 2004 Dec 21.

PMID:
15613488
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.

Cartron PF, Gallenne T, Bougras G, Gautier F, Manero F, Vusio P, Meflah K, Vallette FM, Juin P.

Mol Cell. 2004 Dec 3;16(5):807-18.

PMID:
15574335
[PubMed - indexed for MEDLINE]
Free Article

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