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Items: 1 to 20 of 39

1.

A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts.

Blüthgen N, Legewie S, Kielbasa SM, Schramme A, Tchernitsa O, Keil J, Solf A, Vingron M, Schäfer R, Herzel H, Sers C.

FEBS J. 2009 Feb;276(4):1024-35. doi: 10.1111/j.1742-4658.2008.06846.x. Epub 2009 Jan 12.

2.

Multiple mechanisms are responsible for transactivation of the epidermal growth factor receptor in mammary epithelial cells.

Rodland KD, Bollinger N, Ippolito D, Opresko LK, Coffey RJ, Zangar R, Wiley HS.

J Biol Chem. 2008 Nov 14;283(46):31477-87. doi: 10.1074/jbc.M800456200. Epub 2008 Sep 9.

3.

Chemokine signaling via the CXCR2 receptor reinforces senescence.

Acosta JC, O'Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, Fumagalli M, Da Costa M, Brown C, Popov N, Takatsu Y, Melamed J, d'Adda di Fagagna F, Bernard D, Hernando E, Gil J.

Cell. 2008 Jun 13;133(6):1006-18. doi: 10.1016/j.cell.2008.03.038.

4.

An inducible autocrine cascade regulates rat hepatocyte proliferation and apoptosis responses to tumor necrosis factor-alpha.

Cosgrove BD, Cheng C, Pritchard JR, Stolz DB, Lauffenburger DA, Griffith LG.

Hepatology. 2008 Jul;48(1):276-88. doi: 10.1002/hep.22335.

5.

DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice.

Meira LB, Bugni JM, Green SL, Lee CW, Pang B, Borenshtein D, Rickman BH, Rogers AB, Moroski-Erkul CA, McFaline JL, Schauer DB, Dedon PC, Fox JG, Samson LD.

J Clin Invest. 2008 Jul;118(7):2516-25. doi: 10.1172/JCI35073.

6.

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.

Haigis KM, Kendall KR, Wang Y, Cheung A, Haigis MC, Glickman JN, Niwa-Kawakita M, Sweet-Cordero A, Sebolt-Leopold J, Shannon KM, Settleman J, Giovannini M, Jacks T.

Nat Genet. 2008 May;40(5):600-8. doi: 10.1038/ng.115. Epub 2008 Mar 30.

7.

TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer.

Merchant NB, Voskresensky I, Rogers CM, Lafleur B, Dempsey PJ, Graves-Deal R, Revetta F, Foutch AC, Rothenberg ML, Washington MK, Coffey RJ.

Clin Cancer Res. 2008 Feb 15;14(4):1182-91. doi: 10.1158/1078-0432.CCR-07-1216.

8.

EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation.

Joslin EJ, Opresko LK, Wells A, Wiley HS, Lauffenburger DA.

J Cell Sci. 2007 Oct 15;120(Pt 20):3688-99. Epub 2007 Sep 25.

9.

Common effector processing mediates cell-specific responses to stimuli.

Miller-Jensen K, Janes KA, Brugge JS, Lauffenburger DA.

Nature. 2007 Aug 2;448(7153):604-8. Epub 2007 Jul 18.

PMID:
17637676
10.

Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases.

Owens DM, Keyse SM.

Oncogene. 2007 May 14;26(22):3203-13. Review.

PMID:
17496916
11.

Quantitative network signal combinations downstream of TCR activation can predict IL-2 production response.

Kemp ML, Wille L, Lewis CL, Nicholson LB, Lauffenburger DA.

J Immunol. 2007 Apr 15;178(8):4984-92.

12.

A module of negative feedback regulators defines growth factor signaling.

Amit I, Citri A, Shay T, Lu Y, Katz M, Zhang F, Tarcic G, Siwak D, Lahad J, Jacob-Hirsch J, Amariglio N, Vaisman N, Segal E, Rechavi G, Alon U, Mills GB, Domany E, Yarden Y.

Nat Genet. 2007 Apr;39(4):503-12. Epub 2007 Feb 25.

PMID:
17322878
13.

Modeling HER2 effects on cell behavior from mass spectrometry phosphotyrosine data.

Kumar N, Wolf-Yadlin A, White FM, Lauffenburger DA.

PLoS Comput Biol. 2007 Jan 5;3(1):e4. Epub 2006 Nov 21.

14.

Oncogenic KRAS provides a uniquely powerful and variable oncogenic contribution among RAS family members in the colonic epithelium.

Keller JW, Franklin JL, Graves-Deal R, Friedman DB, Whitwell CW, Coffey RJ.

J Cell Physiol. 2007 Mar;210(3):740-9.

PMID:
17133351
15.

Oncogenic K-RAS subverts the antiapoptotic role of N-RAS and alters modulation of the N-RAS:gelsolin complex.

Keller JW, Haigis KM, Franklin JL, Whitehead RH, Jacks T, Coffey RJ.

Oncogene. 2007 May 10;26(21):3051-9. Epub 2006 Nov 20.

PMID:
17130841
16.

GROalpha is highly expressed in adenocarcinoma of the colon and down-regulates fibulin-1.

Wen Y, Giardina SF, Hamming D, Greenman J, Zachariah E, Bacolod MD, Liu H, Shia J, Amenta PS, Barany F, Paty P, Gerald W, Notterman D.

Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):5951-9.

17.

Data-driven modelling of signal-transduction networks.

Janes KA, Yaffe MB.

Nat Rev Mol Cell Biol. 2006 Nov;7(11):820-8. Review.

PMID:
17057752
18.

The response of human epithelial cells to TNF involves an inducible autocrine cascade.

Janes KA, Gaudet S, Albeck JG, Nielsen UB, Lauffenburger DA, Sorger PK.

Cell. 2006 Mar 24;124(6):1225-39.

19.

A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis.

Janes KA, Albeck JG, Gaudet S, Sorger PK, Lauffenburger DA, Yaffe MB.

Science. 2005 Dec 9;310(5754):1646-53.

20.

A compendium of signals and responses triggered by prodeath and prosurvival cytokines.

Gaudet S, Janes KA, Albeck JG, Pace EA, Lauffenburger DA, Sorger PK.

Mol Cell Proteomics. 2005 Oct;4(10):1569-90. Epub 2005 Jul 18.

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