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Items: 1 to 20 of 58

1.

Synthesis of Oxadiazole-2-oxide Analogues as Potential Antischistosomal Agents.

Rai G, Thomas CJ, Leister W, Maloney DJ.

Tetrahedron Lett. 2009 Apr;50(15):1710-1713.

2.

A novel biological activity of praziquantel requiring voltage-operated Ca2+ channel beta subunits: subversion of flatworm regenerative polarity.

Nogi T, Zhang D, Chan JD, Marchant JS.

PLoS Negl Trop Dis. 2009 Jun 23;3(6):e464. doi: 10.1371/journal.pntd.0000464.

3.

Low exchangeability of selenocysteine, the 21st amino acid, in vertebrate proteins.

Castellano S, Andrés AM, Bosch E, Bayes M, Guigó R, Clark AG.

Mol Biol Evol. 2009 Sep;26(9):2031-40. doi: 10.1093/molbev/msp109. Epub 2009 Jun 1.

4.

C-nitroso donors of nitric oxide.

Chakrapani H, Bartberger MD, Toone EJ.

J Org Chem. 2009 Feb 20;74(4):1450-3. doi: 10.1021/jo802517t.

PMID:
19146387
5.

PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release.

Singh R, Manjunatha U, Boshoff HI, Ha YH, Niyomrattanakit P, Ledwidge R, Dowd CS, Lee IY, Kim P, Zhang L, Kang S, Keller TH, Jiricek J, Barry CE 3rd.

Science. 2008 Nov 28;322(5906):1392-5. doi: 10.1126/science.1164571.

6.

Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis.

Doenhoff MJ, Cioli D, Utzinger J.

Curr Opin Infect Dis. 2008 Dec;21(6):659-67. doi: 10.1097/QCO.0b013e328318978f. Review.

PMID:
18978535
7.

Benznidazole and Chagas disease: can an old drug be the answer to an old problem?

Mady C, Ianni BM, de Souza JL Jr.

Expert Opin Investig Drugs. 2008 Oct;17(10):1427-33. doi: 10.1517/13543784.17.10.1427 . Review.

PMID:
18808305
8.

Mitochondria-targeted chemotherapeutics: the rational design of gold(I) N-heterocyclic carbene complexes that are selectively toxic to cancer cells and target protein selenols in preference to thiols.

Hickey JL, Ruhayel RA, Barnard PJ, Baker MV, Berners-Price SJ, Filipovska A.

J Am Chem Soc. 2008 Sep 24;130(38):12570-1. doi: 10.1021/ja804027j. Epub 2008 Aug 26.

PMID:
18729360
9.

A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase.

Lea WA, Jadhav A, Rai G, Sayed AA, Cass CL, Inglese J, Williams DL, Austin CP, Simeonov A.

Assay Drug Dev Technol. 2008 Aug;6(4):551-5. doi: 10.1089/adt.2008.149.

10.

Helminth infections: the great neglected tropical diseases.

Hotez PJ, Brindley PJ, Bethony JM, King CH, Pearce EJ, Jacobson J.

J Clin Invest. 2008 Apr;118(4):1311-21. doi: 10.1172/JCI34261. Review.

11.

Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cells.

Anestål K, Prast-Nielsen S, Cenas N, Arnér ES.

PLoS One. 2008 Apr 2;3(4):e1846. doi: 10.1371/journal.pone.0001846.

12.

A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes.

Wilkinson SR, Taylor MC, Horn D, Kelly JM, Cheeseman I.

Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5022-7. doi: 10.1073/pnas.0711014105. Epub 2008 Mar 26.

13.

Identification of oxadiazoles as new drug leads for the control of schistosomiasis.

Sayed AA, Simeonov A, Thomas CJ, Inglese J, Austin CP, Williams DL.

Nat Med. 2008 Apr;14(4):407-12. doi: 10.1038/nm1737. Epub 2008 Mar 16.

14.

The unacknowledged impact of chronic schistosomiasis.

King CH, Dangerfield-Cha M.

Chronic Illn. 2008 Mar;4(1):65-79. doi: 10.1177/1742395307084407. Review.

PMID:
18322031
15.

Glutathione reductase and thioredoxin reductase at the crossroad: the structure of Schistosoma mansoni thioredoxin glutathione reductase.

Angelucci F, Miele AE, Boumis G, Dimastrogiovanni D, Brunori M, Bellelli A.

Proteins. 2008 Aug 15;72(3):936-45. doi: 10.1002/prot.21986.

PMID:
18300227
16.

Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade.

Simeonov A, Jadhav A, Sayed AA, Wang Y, Nelson ME, Thomas CJ, Inglese J, Williams DL, Austin CP.

PLoS Negl Trop Dis. 2008 Jan 2;2(1):e127. doi: 10.1371/journal.pntd.0000127.

17.

The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics.

Lundberg JO, Weitzberg E, Gladwin MT.

Nat Rev Drug Discov. 2008 Feb;7(2):156-67. doi: 10.1038/nrd2466. Review.

PMID:
18167491
18.

In vitro antihydatic action of IFN-gamma is dependent on the nitric oxide pathway.

Amri M, Aissa SA, Belguendouz H, Mezioug D, Touil-Boukoffa C.

J Interferon Cytokine Res. 2007 Sep;27(9):781-7.

PMID:
17892399
19.

Nitric oxide donor beta2-agonists: furoxan derivatives containing the fenoterol moiety and related furazans.

Buonsanti MF, Bertinaria M, Stilo AD, Cena C, Fruttero R, Gasco A.

J Med Chem. 2007 Oct 4;50(20):5003-11. Epub 2007 Sep 11.

PMID:
17845020
20.

Tumor necrosis factor (TNF) receptor-1 (TNFp55) signal transduction and macrophage-derived soluble TNF are crucial for nitric oxide-mediated Trypanosoma congolense parasite killing.

Magez S, Radwanska M, Drennan M, Fick L, Baral TN, Allie N, Jacobs M, Nedospasov S, Brombacher F, Ryffel B, De Baetselier P.

J Infect Dis. 2007 Sep 15;196(6):954-62. Epub 2007 Aug 10.

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