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Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors.

Huang J, Wu S, Wu CL, Manning BD.

Cancer Res. 2009 Aug 1;69(15):6107-14. doi: 10.1158/0008-5472.CAN-09-0975. Epub 2009 Jul 14.


Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.

Zhang HH, Huang J, Düvel K, Boback B, Wu S, Squillace RM, Wu CL, Manning BD.

PLoS One. 2009 Jul 10;4(7):e6189. doi: 10.1371/journal.pone.0006189.


DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.

Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM, Gray NS, Sabatini DM.

Cell. 2009 May 29;137(5):873-86. doi: 10.1016/j.cell.2009.03.046. Epub 2009 May 14.


New insights into mTOR signaling: mTORC2 and beyond.

Alessi DR, Pearce LR, García-Martínez JM.

Sci Signal. 2009 Apr 21;2(67):pe27. doi: 10.1126/scisignal.267pe27.


Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation.

Zheng B, Jeong JH, Asara JM, Yuan YY, Granter SR, Chin L, Cantley LC.

Mol Cell. 2009 Jan 30;33(2):237-47. doi: 10.1016/j.molcel.2008.12.026.


mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).

García-Martínez JM, Alessi DR.

Biochem J. 2008 Dec 15;416(3):375-85. doi: 10.1042/BJ20081668.


Linear motif atlas for phosphorylation-dependent signaling.

Miller ML, Jensen LJ, Diella F, Jørgensen C, Tinti M, Li L, Hsiung M, Parker SA, Bordeaux J, Sicheritz-Ponten T, Olhovsky M, Pasculescu A, Alexander J, Knapp S, Blom N, Bork P, Li S, Cesareni G, Pawson T, Turk BE, Yaffe MB, Brunak S, Linding R.

Sci Signal. 2008 Sep 2;1(35):ra2. doi: 10.1126/scisignal.1159433.


Regulation of TORC1 by Rag GTPases in nutrient response.

Kim E, Goraksha-Hicks P, Li L, Neufeld TP, Guan KL.

Nat Cell Biol. 2008 Aug;10(8):935-45. doi: 10.1038/ncb1753. Epub 2008 Jul 6.


Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling.

Ikenoue T, Inoki K, Yang Q, Zhou X, Guan KL.

EMBO J. 2008 Jul 23;27(14):1919-31. doi: 10.1038/emboj.2008.119. Epub 2008 Jun 19. Erratum in: EMBO J. 2008 Aug 20;27(16):2270.


The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C.

Facchinetti V, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C, Lowry C, Newton AC, Mao Y, Miao RQ, Sessa WC, Qin J, Zhang P, Su B, Jacinto E.

EMBO J. 2008 Jul 23;27(14):1932-43. doi: 10.1038/emboj.2008.120. Epub 2008 Jun 19.


The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.

Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM.

Science. 2008 Jun 13;320(5882):1496-501. doi: 10.1126/science.1157535. Epub 2008 May 22.


The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.

Huang J, Manning BD.

Biochem J. 2008 Jun 1;412(2):179-90. doi: 10.1042/BJ20080281. Review.


The TSC1-TSC2 complex is required for proper activation of mTOR complex 2.

Huang J, Dibble CC, Matsuzaki M, Manning BD.

Mol Cell Biol. 2008 Jun;28(12):4104-15. doi: 10.1128/MCB.00289-08. Epub 2008 Apr 14.


A label-free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen.

Asara JM, Christofk HR, Freimark LM, Cantley LC.

Proteomics. 2008 Mar;8(5):994-9. doi: 10.1002/pmic.200700426.


TOR regulation of AGC kinases in yeast and mammals.

Jacinto E, Lorberg A.

Biochem J. 2008 Feb 15;410(1):19-37. doi: 10.1042/BJ20071518. Review.


Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits.

Hayashi T, Hatanaka M, Nagao K, Nakaseko Y, Kanoh J, Kokubu A, Ebe M, Yanagida M.

Genes Cells. 2007 Dec;12(12):1357-70.


PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.

Thedieck K, Polak P, Kim ML, Molle KD, Cohen A, Jenö P, Arrieumerlou C, Hall MN.

PLoS One. 2007 Nov 21;2(11):e1217.


Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance.

Tremblay F, Brûlé S, Hee Um S, Li Y, Masuda K, Roden M, Sun XJ, Krebs M, Polakiewicz RD, Thomas G, Marette A.

Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14056-61. Epub 2007 Aug 20.


Rapamycin regulates the phosphorylation of rictor.

Akcakanat A, Singh G, Hung MC, Meric-Bernstam F.

Biochem Biophys Res Commun. 2007 Oct 19;362(2):330-3. Epub 2007 Aug 8.

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