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Results: 1 to 20 of 32

1.

A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis.

Sato T, Tang TC, Reubins G, Fei JZ, Fujimoto T, Kienlen-Campard P, Constantinescu SN, Octave JN, Aimoto S, Smith SO.

Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1421-6. doi: 10.1073/pnas.0812261106. Epub 2009 Jan 21.

PMID:
19164538
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Amyloid-beta peptide (Abeta) neurotoxicity is modulated by the rate of peptide aggregation: Abeta dimers and trimers correlate with neurotoxicity.

Hung LW, Ciccotosto GD, Giannakis E, Tew DJ, Perez K, Masters CL, Cappai R, Wade JD, Barnham KJ.

J Neurosci. 2008 Nov 12;28(46):11950-8. doi: 10.1523/JNEUROSCI.3916-08.2008.

PMID:
19005060
[PubMed - indexed for MEDLINE]
Free Article
3.

Amyloid beta-protein assembly and Alzheimer disease.

Roychaudhuri R, Yang M, Hoshi MM, Teplow DB.

J Biol Chem. 2009 Feb 20;284(8):4749-53. doi: 10.1074/jbc.R800036200. Epub 2008 Oct 9. Review. No abstract available.

PMID:
18845536
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Amyloid beta-protein monomer folding: free-energy surfaces reveal alloform-specific differences.

Yang M, Teplow DB.

J Mol Biol. 2008 Dec 12;384(2):450-64. doi: 10.1016/j.jmb.2008.09.039. Epub 2008 Sep 24.

PMID:
18835397
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Structural classification of toxic amyloid oligomers.

Glabe CG.

J Biol Chem. 2008 Oct 31;283(44):29639-43. doi: 10.1074/jbc.R800016200. Epub 2008 Aug 22. Review.

PMID:
18723507
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.

Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ.

Nat Med. 2008 Aug;14(8):837-42. doi: 10.1038/nm1782. Epub 2008 Jun 22.

PMID:
18568035
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Evidence of fibril-like β-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's β-amyloid.

Chimon S, Shaibat MA, Jones CR, Calero DC, Aizezi B, Ishii Y.

Nat Struct Mol Biol. 2007 Dec;14(12):1157-64.

PMID:
18059284
[PubMed - indexed for MEDLINE]
8.

A beta oligomers - a decade of discovery.

Walsh DM, Selkoe DJ.

J Neurochem. 2007 Jun;101(5):1172-84. Epub 2007 Feb 5. Review.

PMID:
17286590
[PubMed - indexed for MEDLINE]
9.

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide.

Haass C, Selkoe DJ.

Nat Rev Mol Cell Biol. 2007 Feb;8(2):101-12. Review.

PMID:
17245412
[PubMed - indexed for MEDLINE]
10.

Preparation of amyloid beta-protein for structural and functional studies.

Teplow DB.

Methods Enzymol. 2006;413:20-33.

PMID:
17046389
[PubMed - indexed for MEDLINE]
11.

Alzheimer's disease.

Blennow K, de Leon MJ, Zetterberg H.

Lancet. 2006 Jul 29;368(9533):387-403. Review.

PMID:
16876668
[PubMed - indexed for MEDLINE]
12.

A specific amyloid-beta protein assembly in the brain impairs memory.

Lesné S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH.

Nature. 2006 Mar 16;440(7082):352-7.

PMID:
16541076
[PubMed - indexed for MEDLINE]
13.

Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.

Townsend M, Shankar GM, Mehta T, Walsh DM, Selkoe DJ.

J Physiol. 2006 Apr 15;572(Pt 2):477-92. Epub 2006 Feb 9.

PMID:
16469784
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function.

Cleary JP, Walsh DM, Hofmeister JJ, Shankar GM, Kuskowski MA, Selkoe DJ, Ashe KH.

Nat Neurosci. 2005 Jan;8(1):79-84. Epub 2004 Dec 19.

PMID:
15608634
[PubMed - indexed for MEDLINE]
15.

Rapid photochemical cross-linking--a new tool for studies of metastable, amyloidogenic protein assemblies.

Bitan G, Teplow DB.

Acc Chem Res. 2004 Jun;37(6):357-64.

PMID:
15196045
[PubMed - indexed for MEDLINE]
16.

Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways.

Bitan G, Kirkitadze MD, Lomakin A, Vollers SS, Benedek GB, Teplow DB.

Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):330-5. Epub 2002 Dec 27.

PMID:
12506200
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies.

Kirkitadze MD, Bitan G, Teplow DB.

J Neurosci Res. 2002 Sep 1;69(5):567-77. Review.

PMID:
12210822
[PubMed - indexed for MEDLINE]
18.

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.

Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ.

Nature. 2002 Apr 4;416(6880):535-9.

PMID:
11932745
[PubMed - indexed for MEDLINE]
19.

Amyloid beta-protein oligomerization: prenucleation interactions revealed by photo-induced cross-linking of unmodified proteins.

Bitan G, Lomakin A, Teplow DB.

J Biol Chem. 2001 Sep 14;276(37):35176-84. Epub 2001 Jul 5.

PMID:
11441003
[PubMed - indexed for MEDLINE]
Free Article
20.

Quantification of beta-sheet amyloid fibril structures with thioflavin T.

LeVine H 3rd.

Methods Enzymol. 1999;309:274-84. No abstract available.

PMID:
10507030
[PubMed - indexed for MEDLINE]

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