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Items: 1 to 20 of 30


Modeling cardiac action potential shortening driven by oxidative stress-induced mitochondrial oscillations in guinea pig cardiomyocytes.

Zhou L, Cortassa S, Wei AC, Aon MA, Winslow RL, O'Rourke B.

Biophys J. 2009 Oct 7;97(7):1843-52. doi: 10.1016/j.bpj.2009.07.029.


Mitochondrial oscillations in physiology and pathophysiology.

Aon MA, Cortassa S, O'Rourke B.

Adv Exp Med Biol. 2008;641:98-117. Review.


Glutathione oxidation as a trigger of mitochondrial depolarization and oscillation in intact hearts.

Slodzinski MK, Aon MA, O'Rourke B.

J Mol Cell Cardiol. 2008 Nov;45(5):650-60. doi: 10.1016/j.yjmcc.2008.07.017. Epub 2008 Aug 7.


Effects of 4'-chlorodiazepam on cellular excitation-contraction coupling and ischaemia-reperfusion injury in rabbit heart.

Brown DA, Aon MA, Akar FG, Liu T, Sorarrain N, O'Rourke B.

Cardiovasc Res. 2008 Jul 1;79(1):141-9. doi: 10.1093/cvr/cvn053. Epub 2008 Feb 26.


Mitochondrial ion channels in cardiac function and dysfunction.

O'Rourke B, Cortassa S, Akar F, Aon M.

Novartis Found Symp. 2007;287:140-51; discussion 152-6. Review.


Heart mitochondria: gates of life and death.

Gustafsson AB, Gottlieb RA.

Cardiovasc Res. 2008 Jan 15;77(2):334-43. Epub 2007 Aug 21. Review.


Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status.

Aon MA, Cortassa S, Maack C, O'Rourke B.

J Biol Chem. 2007 Jul 27;282(30):21889-900. Epub 2007 May 31.


A wave of reactive oxygen species (ROS)-induced ROS release in a sea of excitable mitochondria.

Brady NR, Hamacher-Brady A, Westerhoff HV, Gottlieb RA.

Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1651-65. Review.


The fundamental organization of cardiac mitochondria as a network of coupled oscillators.

Aon MA, Cortassa S, O'Rourke B.

Biophys J. 2006 Dec 1;91(11):4317-27. Epub 2006 Sep 15.


A computational model integrating electrophysiology, contraction, and mitochondrial bioenergetics in the ventricular myocyte.

Cortassa S, Aon MA, O'Rourke B, Jacques R, Tseng HJ, Marbán E, Winslow RL.

Biophys J. 2006 Aug 15;91(4):1564-89. Epub 2006 May 5.


The mitochondrial origin of postischemic arrhythmias.

Akar FG, Aon MA, Tomaselli GF, O'Rourke B.

J Clin Invest. 2005 Dec;115(12):3527-35. Epub 2005 Nov 10.


Mitochondrial criticality: a new concept at the turning point of life or death.

Aon MA, Cortassa S, Akar FG, O'Rourke B.

Biochim Biophys Acta. 2006 Feb;1762(2):232-40. Epub 2005 Sep 27. Review.


Mitochondrial ion channels: gatekeepers of life and death.

O'Rourke B, Cortassa S, Aon MA.

Physiology (Bethesda). 2005 Oct;20:303-15. Review.


ATP flux through creatine kinase in the normal, stressed, and failing human heart.

Weiss RG, Gerstenblith G, Bottomley PA.

Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):808-13. Epub 2005 Jan 12.


A mitochondrial oscillator dependent on reactive oxygen species.

Cortassa S, Aon MA, Winslow RL, O'Rourke B.

Biophys J. 2004 Sep;87(3):2060-73.


Coordinated behavior of mitochondria in both space and time: a reactive oxygen species-activated wave of mitochondrial depolarization.

Brady NR, Elmore SP, van Beek JJ, Krab K, Courtoy PJ, Hue L, Westerhoff HV.

Biophys J. 2004 Sep;87(3):2022-34.


Percolation and criticality in a mitochondrial network.

Aon MA, Cortassa S, O'Rourke B.

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4447-52. Epub 2004 Mar 18.


Basic mechanisms of cardiac impulse propagation and associated arrhythmias.

Kléber AG, Rudy Y.

Physiol Rev. 2004 Apr;84(2):431-88. Review.


Antioxidants in myocardial ischemia-reperfusion injury: therapeutic potential and basic mechanisms.

Marczin N, El-Habashi N, Hoare GS, Bundy RE, Yacoub M.

Arch Biochem Biophys. 2003 Dec 15;420(2):222-36. Review.

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