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Items: 1 to 20 of 35

1.

Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).

Sidique S, Ardecky R, Su Y, Narisawa S, Brown B, Millán JL, Sergienko E, Cosford ND.

Bioorg Med Chem Lett. 2009 Jan 1;19(1):222-5. doi: 10.1016/j.bmcl.2008.10.107. Epub 2008 Oct 31.

2.

Upregulation of alkaline phosphatase and pyrophosphate hydrolysis: potential mechanism for uremic vascular calcification.

Lomashvili KA, Garg P, Narisawa S, Millan JL, O'Neill WC.

Kidney Int. 2008 May;73(9):1024-30. doi: 10.1038/ki.2008.26. Epub 2008 Feb 20.

3.

Enzyme replacement therapy for murine hypophosphatasia.

Millán JL, Narisawa S, Lemire I, Loisel TP, Boileau G, Leonard P, Gramatikova S, Terkeltaub R, Camacho NP, McKee MD, Crine P, Whyte MP.

J Bone Miner Res. 2008 Jun;23(6):777-87.

4.

Novel inhibitors of alkaline phosphatase suppress vascular smooth muscle cell calcification.

Narisawa S, Harmey D, Yadav MC, O'Neill WC, Hoylaerts MF, Millán JL.

J Bone Miner Res. 2007 Nov;22(11):1700-10.

5.

Building a pharmacological lexicon: small molecule discovery in academia.

Lazo JS, Brady LS, Dingledine R.

Mol Pharmacol. 2007 Jul;72(1):1-7. Epub 2007 Apr 3. Review.

6.

Reduced plasma pyrophosphate levels in hemodialysis patients.

Lomashvili KA, Khawandi W, O'Neill WC.

J Am Soc Nephrol. 2005 Aug;16(8):2495-500. Epub 2005 Jun 15.

7.

NIH Molecular Libraries Initiative.

Austin CP, Brady LS, Insel TR, Collins FS.

Science. 2004 Nov 12;306(5699):1138-9. No abstract available.

PMID:
15542455
8.

Residues determining the binding specificity of uncompetitive inhibitors to tissue-nonspecific alkaline phosphatase.

Kozlenkov A, Le Du MH, Cuniasse P, Ny T, Hoylaerts MF, Millán JL.

J Bone Miner Res. 2004 Nov;19(11):1862-72. Epub 2004 Jun 28.

9.

Phosphate-induced vascular calcification: role of pyrophosphate and osteopontin.

Lomashvili KA, Cobbs S, Hennigar RA, Hardcastle KI, O'Neill WC.

J Am Soc Nephrol. 2004 Jun;15(6):1392-401.

10.
11.

Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification.

Rutsch F, Ruf N, Vaingankar S, Toliat MR, Suk A, Höhne W, Schauer G, Lehmann M, Roscioli T, Schnabel D, Epplen JT, Knisely A, Superti-Furga A, McGill J, Filippone M, Sinaiko AR, Vallance H, Hinrichs B, Smith W, Ferre M, Terkeltaub R, Nürnberg P.

Nat Genet. 2003 Aug;34(4):379-81.

PMID:
12881724
12.
13.

Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization.

Hessle L, Johnson KA, Anderson HC, Narisawa S, Sali A, Goding JW, Terkeltaub R, Millan JL.

Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9445-9. Epub 2002 Jun 24.

14.

Inorganic pyrophosphate generation and disposition in pathophysiology.

Terkeltaub RA.

Am J Physiol Cell Physiol. 2001 Jul;281(1):C1-C11. Review.

15.

PC-1 nucleoside triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcification.

Rutsch F, Vaingankar S, Johnson K, Goldfine I, Maddux B, Schauerte P, Kalhoff H, Sano K, Boisvert WA, Superti-Furga A, Terkeltaub R.

Am J Pathol. 2001 Feb;158(2):543-54.

16.

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays.

Zhang JH, Chung TD, Oldenburg KR.

J Biomol Screen. 1999;4(2):67-73.

PMID:
10838414
17.

Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasia.

Fedde KN, Blair L, Silverstein J, Coburn SP, Ryan LM, Weinstein RS, Waymire K, Narisawa S, Millán JL, MacGregor GR, Whyte MP.

J Bone Miner Res. 1999 Dec;14(12):2015-26.

18.

A robotics-based automated assay for inorganic and organic phosphates.

Cogan EB, Birrell GB, Griffith OH.

Anal Biochem. 1999 Jun 15;271(1):29-35.

PMID:
10361001
19.

Isolation of calcifiable vesicles from human atherosclerotic aortas.

Hsu HH, Camacho NP.

Atherosclerosis. 1999 Apr;143(2):353-62.

PMID:
10217364
20.

A model of the transition state in the alkaline phosphatase reaction.

Holtz KM, Stec B, Kantrowitz ER.

J Biol Chem. 1999 Mar 26;274(13):8351-4.

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