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Results: 1 to 20 of 47

1.

Differences in the rate of repair of O6-alkylguanines in different sequence contexts by O6-alkylguanine-DNA alkyltransferase.

Coulter R, Blandino M, Tomlinson JM, Pauly GT, Krajewska M, Moschel RC, Peterson LA, Pegg AE, Spratt TE.

Chem Res Toxicol. 2007 Dec;20(12):1966-71. Epub 2007 Nov 1.

PMID:
17975884
[PubMed - indexed for MEDLINE]
2.

The structural basis for the mutagenicity of O(6)-methyl-guanine lesions.

Warren JJ, Forsberg LJ, Beese LS.

Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19701-6. Epub 2006 Dec 18.

PMID:
17179038
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Interactions of human O6-alkylguanine-DNA alkyltransferase (AGT) with short single-stranded DNAs.

Rasimas JJ, Kar SR, Pegg AE, Fried MG.

J Biol Chem. 2007 Feb 2;282(5):3357-66. Epub 2006 Nov 30.

PMID:
17138560
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

DNA sequence context affects repair of the tobacco-specific adduct O(6)-[4-Oxo-4-(3-pyridyl)butyl]guanine by human O(6)-alkylguanine-DNA alkyltransferases.

Mijal RS, Kanugula S, Vu CC, Fang Q, Pegg AE, Peterson LA.

Cancer Res. 2006 May 1;66(9):4968-74.

PMID:
16651455
[PubMed - indexed for MEDLINE]
Free Article
5.

Kinetics of O(6)-methyl-2'-deoxyguanosine repair by O(6)-alkylguanine DNA alkyltransferase within K-ras gene-derived DNA sequences.

Guza R, Rajesh M, Fang Q, Pegg AE, Tretyakova N.

Chem Res Toxicol. 2006 Apr;19(4):531-8.

PMID:
16608164
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Kinetic analysis of steps in the repair of damaged DNA by human O6-alkylguanine-DNA alkyltransferase.

Zang H, Fang Q, Pegg AE, Guengerich FP.

J Biol Chem. 2005 Sep 2;280(35):30873-81. Epub 2005 Jul 5.

PMID:
16000301
[PubMed - indexed for MEDLINE]
Free Article
7.

The structure of the human AGT protein bound to DNA and its implications for damage detection.

Duguid EM, Rice PA, He C.

J Mol Biol. 2005 Jul 22;350(4):657-66.

PMID:
15964013
[PubMed - indexed for MEDLINE]
8.
9.

DNA binding and nucleotide flipping by the human DNA repair protein AGT.

Daniels DS, Woo TT, Luu KX, Noll DM, Clarke ND, Pegg AE, Tainer JA.

Nat Struct Mol Biol. 2004 Aug;11(8):714-20. Epub 2004 Jun 27.

PMID:
15221026
[PubMed - indexed for MEDLINE]
10.

Formation of diastereomeric benzo[a]pyrene diol epoxide-guanine adducts in p53 gene-derived DNA sequences.

Matter B, Wang G, Jones R, Tretyakova N.

Chem Res Toxicol. 2004 Jun;17(6):731-41.

PMID:
15206894
[PubMed - indexed for MEDLINE]
11.

The repair of the tobacco specific nitrosamine derived adduct O6-[4-Oxo-4-(3-pyridyl)butyl]guanine by O6-alkylguanine-DNA alkyltransferase variants.

Mijal RS, Thomson NM, Fleischer NL, Pauly GT, Moschel RC, Kanugula S, Fang Q, Pegg AE, Peterson LA.

Chem Res Toxicol. 2004 Mar;17(3):424-34.

PMID:
15025514
[PubMed - indexed for MEDLINE]
12.

Endogenous 5-methylcytosine protects neighboring guanines from N7 and O6-methylation and O6-pyridyloxobutylation by the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

Ziegel R, Shallop A, Upadhyaya P, Jones R, Tretyakova N.

Biochemistry. 2004 Jan 20;43(2):540-9.

PMID:
14717610
[PubMed - indexed for MEDLINE]
13.

Tobacco carcinogens, their biomarkers and tobacco-induced cancer.

Hecht SS.

Nat Rev Cancer. 2003 Oct;3(10):733-44. Review. Erratum in: Nat Rev Cancer. 2004 Jan;4(1):84.

PMID:
14570033
[PubMed - indexed for MEDLINE]
14.

Modulation of human nucleotide excision repair by 5-methylcytosines.

Muheim R, Buterin T, Colgate KC, Kolbanovsij A, Geacintov NE, Naegeli H.

Biochemistry. 2003 Mar 25;42(11):3247-54.

PMID:
12641456
[PubMed - indexed for MEDLINE]
15.

DNA-binding mechanism of O6-alkylguanine-DNA alkyltransferase. Effects of protein and DNA alkylation on complex stability.

Rasimas JJ, Pegg AE, Fried MG.

J Biol Chem. 2003 Mar 7;278(10):7973-80. Epub 2002 Dec 20.

PMID:
12496275
[PubMed - indexed for MEDLINE]
Free Article
16.

Repair of oligodeoxyribonucleotides by O(6)-alkylguanine-DNA alkyltransferase.

Luu KX, Kanugula S, Pegg AE, Pauly GT, Moschel RC.

Biochemistry. 2002 Jul 9;41(27):8689-97.

PMID:
12093287
[PubMed - indexed for MEDLINE]
17.

Inactivation and degradation of O(6)-alkylguanine-DNA alkyltransferase after reaction with nitric oxide.

Liu L, Xu-Welliver M, Kanugula S, Pegg AE.

Cancer Res. 2002 Jun 1;62(11):3037-43.

PMID:
12036910
[PubMed - indexed for MEDLINE]
Free Article
18.

Degradation of the alkylated form of the DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase.

Xu-Welliver M, Pegg AE.

Carcinogenesis. 2002 May;23(5):823-30.

PMID:
12016156
[PubMed - indexed for MEDLINE]
Free Article
19.

Conformational changes of a benzo[a]pyrene diol epoxide-N(2)-dG adduct induced by a 5'-flanking 5-methyl-substituted cytosine in a (Me)CG double-stranded oligonucleotide sequence context.

Huang X, Colgate KC, Kolbanovskiy A, Amin S, Geacintov NE.

Chem Res Toxicol. 2002 Mar;15(3):438-44.

PMID:
11896693
[PubMed - indexed for MEDLINE]
20.

O(6)-Methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in non-small cell lung cancer.

Wolf P, Hu YC, Doffek K, Sidransky D, Ahrendt SA.

Cancer Res. 2001 Nov 15;61(22):8113-7.

PMID:
11719438
[PubMed - indexed for MEDLINE]
Free Article
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