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Items: 1 to 20 of 135


Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization.

Usui T, Foster SS, Petrini JH.

Mol Cell. 2009 Jan 30;33(2):147-59. doi: 10.1016/j.molcel.2008.12.022.


Activation of ATR and related PIKKs.

Mordes DA, Cortez D.

Cell Cycle. 2008 Sep 15;7(18):2809-12. Epub 2008 Sep 30.


Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response.

Morin I, Ngo HP, Greenall A, Zubko MK, Morrice N, Lydall D.

EMBO J. 2008 Sep 17;27(18):2400-10. doi: 10.1038/emboj.2008.171. Epub 2008 Aug 28.


Regulation of Chk1 by its C-terminal domain.

Kosoy A, O'Connell MJ.

Mol Biol Cell. 2008 Nov;19(11):4546-53. doi: 10.1091/mbc.E08-04-0444. Epub 2008 Aug 20.


DNA replication checkpoint promotes G1-S transcription by inactivating the MBF repressor Nrm1.

de Bruin RA, Kalashnikova TI, Aslanian A, Wohlschlegel J, Chahwan C, Yates JR 3rd, Russell P, Wittenberg C.

Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11230-5. doi: 10.1073/pnas.0801106105. Epub 2008 Aug 5.


The DNA replication checkpoint directly regulates MBF-dependent G1/S transcription.

Dutta C, Patel PK, Rosebrock A, Oliva A, Leatherwood J, Rhind N.

Mol Cell Biol. 2008 Oct;28(19):5977-85. doi: 10.1128/MCB.00596-08. Epub 2008 Jul 28.


The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint.

Bassermann F, Frescas D, Guardavaccaro D, Busino L, Peschiaroli A, Pagano M.

Cell. 2008 Jul 25;134(2):256-67. doi: 10.1016/j.cell.2008.05.043.


Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair.

Chen CC, Carson JJ, Feser J, Tamburini B, Zabaronick S, Linger J, Tyler JK.

Cell. 2008 Jul 25;134(2):231-43. doi: 10.1016/j.cell.2008.06.035.


Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379.

Lovly CM, Yan L, Ryan CE, Takada S, Piwnica-Worms H.

Mol Cell Biol. 2008 Oct;28(19):5874-85. doi: 10.1128/MCB.00821-08. Epub 2008 Jul 21.


Rad53 regulates replication fork restart after DNA damage in Saccharomyces cerevisiae.

Szyjka SJ, Aparicio JG, Viggiani CJ, Knott S, Xu W, Tavaré S, Aparicio OM.

Genes Dev. 2008 Jul 15;22(14):1906-20. doi: 10.1101/gad.1660408.


Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage.

Stracker TH, Couto SS, Cordon-Cardo C, Matos T, Petrini JH.

Mol Cell. 2008 Jul 11;31(1):21-32. doi: 10.1016/j.molcel.2008.04.028. Erratum in: Mol Cell. 2008 Dec 26;32(6):889.


ATR: an essential regulator of genome integrity.

Cimprich KA, Cortez D.

Nat Rev Mol Cell Biol. 2008 Aug;9(8):616-27. doi: 10.1038/nrm2450. Epub 2008 Jul 2. Review.


Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks.

Segurado M, Diffley JF.

Genes Dev. 2008 Jul 1;22(13):1816-27. doi: 10.1101/gad.477208.


Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade.

Lee H, Yuan C, Hammet A, Mahajan A, Chen ES, Wu MR, Su MI, Heierhorst J, Tsai MD.

Mol Cell. 2008 Jun 20;30(6):767-78. doi: 10.1016/j.molcel.2008.05.013.


Autophosphorylated residues involved in the regulation of human chk2 in vitro.

Gabant G, Lorphelin A, Nozerand N, Marchetti C, Bellanger L, Dedieu A, Quéméneur E, Alpha-Bazin B.

J Mol Biol. 2008 Jul 11;380(3):489-503. doi: 10.1016/j.jmb.2008.04.053. Epub 2008 May 1.


Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.

Sidi S, Sanda T, Kennedy RD, Hagen AT, Jette CA, Hoffmans R, Pascual J, Imamura S, Kishi S, Amatruda JF, Kanki JP, Green DR, D'Andrea AA, Look AT.

Cell. 2008 May 30;133(5):864-77. doi: 10.1016/j.cell.2008.03.037.


Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis.

Minter-Dykhouse K, Ward I, Huen MS, Chen J, Lou Z.

J Cell Biol. 2008 Jun 2;181(5):727-35. doi: 10.1083/jcb.200801083. Epub 2008 May 26.


Chk1 and Claspin potentiate PCNA ubiquitination.

Yang XH, Shiotani B, Classon M, Zou L.

Genes Dev. 2008 May 1;22(9):1147-52. doi: 10.1101/gad.1632808.


A conserved proliferating cell nuclear antigen-interacting protein sequence in Chk1 is required for checkpoint function.

Scorah J, Dong MQ, Yates JR 3rd, Scott M, Gillespie D, McGowan CH.

J Biol Chem. 2008 Jun 20;283(25):17250-9. doi: 10.1074/jbc.M800369200. Epub 2008 Apr 30.


Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons.

Yuan Z, Becker EB, Merlo P, Yamada T, DiBacco S, Konishi Y, Schaefer EM, Bonni A.

Science. 2008 Mar 21;319(5870):1665-8. doi: 10.1126/science.1152337.

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