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Items: 1 to 20 of 43

1.

LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer.

Xie H, Valera VA, Merino MJ, Amato AM, Signoretti S, Linehan WM, Sukhatme VP, Seth P.

Mol Cancer Ther. 2009 Mar;8(3):626-35. doi: 10.1158/1535-7163.MCT-08-1049. Epub 2009 Mar 10.

2.

Hypoxia, HIF1 and glucose metabolism in the solid tumour.

Denko NC.

Nat Rev Cancer. 2008 Sep;8(9):705-13. doi: 10.1038/nrc2468.

PMID:
19143055
3.

A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death.

Wood TE, Dalili S, Simpson CD, Hurren R, Mao X, Saiz FS, Gronda M, Eberhard Y, Minden MD, Bilan PJ, Klip A, Batey RA, Schimmer AD.

Mol Cancer Ther. 2008 Nov;7(11):3546-55. doi: 10.1158/1535-7163.MCT-08-0569.

4.
5.

HIF-dependent antitumorigenic effect of antioxidants in vivo.

Gao P, Zhang H, Dinavahi R, Li F, Xiang Y, Raman V, Bhujwalla ZM, Felsher DW, Cheng L, Pevsner J, Lee LA, Semenza GL, Dang CV.

Cancer Cell. 2007 Sep;12(3):230-8.

6.

Hereditary leiomyomatosis and renal cell cancer: a syndrome associated with an aggressive form of inherited renal cancer.

Grubb RL 3rd, Franks ME, Toro J, Middelton L, Choyke L, Fowler S, Torres-Cabala C, Glenn GM, Choyke P, Merino MJ, Zbar B, Pinto PA, Srinivasan R, Coleman JA, Linehan WM.

J Urol. 2007 Jun;177(6):2074-9; discussion 2079-80.

PMID:
17509289
7.

Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway.

Pollard PJ, Spencer-Dene B, Shukla D, Howarth K, Nye E, El-Bahrawy M, Deheragoda M, Joannou M, McDonald S, Martin A, Igarashi P, Varsani-Brown S, Rosewell I, Poulsom R, Maxwell P, Stamp GW, Tomlinson IP.

Cancer Cell. 2007 Apr;11(4):311-9.

8.

HIF and fumarate hydratase in renal cancer.

Sudarshan S, Linehan WM, Neckers L.

Br J Cancer. 2007 Feb 12;96(3):403-7. Epub 2007 Jan 9. Review.

9.

Hypoxia-inducible factors: central regulators of the tumor phenotype.

Gordan JD, Simon MC.

Curr Opin Genet Dev. 2007 Feb;17(1):71-7. Epub 2007 Jan 8. Review.

10.

NAD(P)H oxidases regulate HIF-2alpha protein expression.

Block K, Gorin Y, Hoover P, Williams P, Chelmicki T, Clark RA, Yoneda T, Abboud HE.

J Biol Chem. 2007 Mar 16;282(11):8019-26. Epub 2007 Jan 2.

11.

Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.

Koivunen P, Hirsilä M, Remes AM, Hassinen IE, Kivirikko KI, Myllyharju J.

J Biol Chem. 2007 Feb 16;282(7):4524-32. Epub 2006 Dec 19.

12.

Pyruvate protects mitochondria from oxidative stress in human neuroblastoma SK-N-SH cells.

Wang X, Perez E, Liu R, Yan LJ, Mallet RT, Yang SH.

Brain Res. 2007 Feb 9;1132(1):1-9. Epub 2006 Dec 15.

13.

Endothelial cell response to lactate: implication of PAR modification of VEGF.

Kumar VB, Viji RI, Kiran MS, Sudhakaran PR.

J Cell Physiol. 2007 May;211(2):477-85.

PMID:
17167776
14.
15.

Lactate stimulates endothelial cell migration.

Beckert S, Farrahi F, Aslam RS, Scheuenstuhl H, Königsrainer A, Hussain MZ, Hunt TK.

Wound Repair Regen. 2006 May-Jun;14(3):321-4.

PMID:
16808811
16.

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance.

Fantin VR, St-Pierre J, Leder P.

Cancer Cell. 2006 Jun;9(6):425-34. Erratum in: Cancer Cell. 2006 Aug;10(2):172.

17.

Cytoprotection by pyruvate through an anti-oxidative mechanism in cultured rat calvarial osteoblasts.

Moriguchi N, Hinoi E, Tsuchihashi Y, Fujimori S, Iemata M, Takarada T, Yoneda Y.

Histol Histopathol. 2006 Sep;21(9):969-77.

PMID:
16763947
18.

Fumarate hydratase enzyme activity in lymphoblastoid cells and fibroblasts of individuals in families with hereditary leiomyomatosis and renal cell cancer.

Pithukpakorn M, Wei MH, Toure O, Steinbach PJ, Glenn GM, Zbar B, Linehan WM, Toro JR.

J Med Genet. 2006 Sep;43(9):755-62. Epub 2006 Apr 5.

19.
20.

Mitochondrial tumour suppressors: a genetic and biochemical update.

Gottlieb E, Tomlinson IP.

Nat Rev Cancer. 2005 Nov;5(11):857-66. Review.

PMID:
16327764
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