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Results: 16

1.

Highly parallel identification of essential genes in cancer cells.

Luo B, Cheung HW, Subramanian A, Sharifnia T, Okamoto M, Yang X, Hinkle G, Boehm JS, Beroukhim R, Weir BA, Mermel C, Barbie DA, Awad T, Zhou X, Nguyen T, Piqani B, Li C, Golub TR, Meyerson M, Hacohen N, Hahn WC, Lander ES, Sabatini DM, Root DE.

Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20380-5. doi: 10.1073/pnas.0810485105. Epub 2008 Dec 17.

PMID:
19091943
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Cancer proliferation gene discovery through functional genomics.

Schlabach MR, Luo J, Solimini NL, Hu G, Xu Q, Li MZ, Zhao Z, Smogorzewska A, Sowa ME, Ang XL, Westbrook TF, Liang AC, Chang K, Hackett JA, Harper JW, Hannon GJ, Elledge SJ.

Science. 2008 Feb 1;319(5863):620-4. doi: 10.1126/science.1149200. Erratum in: Science.2008 Apr 18;320(5874):316.

PMID:
18239126
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Profiling essential genes in human mammary cells by multiplex RNAi screening.

Silva JM, Marran K, Parker JS, Silva J, Golding M, Schlabach MR, Elledge SJ, Hannon GJ, Chang K.

Science. 2008 Feb 1;319(5863):617-20. doi: 10.1126/science.1149185.

PMID:
18239125
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Comparison of siRNA-induced off-target RNA and protein effects.

Alemán LM, Doench J, Sharp PA.

RNA. 2007 Mar;13(3):385-95. Epub 2007 Jan 19.

PMID:
17237357
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Minimizing the risk of reporting false positives in large-scale RNAi screens.

Echeverri CJ, Beachy PA, Baum B, Boutros M, Buchholz F, Chanda SK, Downward J, Ellenberg J, Fraser AG, Hacohen N, Hahn WC, Jackson AL, Kiger A, Linsley PS, Lum L, Ma Y, Mathey-Prévôt B, Root DE, Sabatini DM, Taipale J, Perrimon N, Bernards R.

Nat Methods. 2006 Oct;3(10):777-9.

PMID:
16990807
[PubMed - indexed for MEDLINE]
6.

Genome-scale loss-of-function screening with a lentiviral RNAi library.

Root DE, Hacohen N, Hahn WC, Lander ES, Sabatini DM.

Nat Methods. 2006 Sep;3(9):715-9. Review.

PMID:
16929317
[PubMed - indexed for MEDLINE]
7.

Lessons from Nature: microRNA-based shRNA libraries.

Chang K, Elledge SJ, Hannon GJ.

Nat Methods. 2006 Sep;3(9):707-14. Review.

PMID:
16929316
[PubMed - indexed for MEDLINE]
8.

shRNA libraries and their use in cancer genetics.

Bernards R, Brummelkamp TR, Beijersbergen RL.

Nat Methods. 2006 Sep;3(9):701-6. Review.

PMID:
16929315
[PubMed - indexed for MEDLINE]
9.

An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors.

Brummelkamp TR, Fabius AW, Mullenders J, Madiredjo M, Velds A, Kerkhoven RM, Bernards R, Beijersbergen RL.

Nat Chem Biol. 2006 Apr;2(4):202-6. Epub 2006 Feb 13.

PMID:
16474381
[PubMed - indexed for MEDLINE]
10.

Second-generation shRNA libraries covering the mouse and human genomes.

Silva JM, Li MZ, Chang K, Ge W, Golding MC, Rickles RJ, Siolas D, Hu G, Paddison PJ, Schlabach MR, Sheth N, Bradshaw J, Burchard J, Kulkarni A, Cavet G, Sachidanandam R, McCombie WR, Cleary MA, Elledge SJ, Hannon GJ.

Nat Genet. 2005 Nov;37(11):1281-8. Epub 2005 Oct 2.

PMID:
16200065
[PubMed - indexed for MEDLINE]
11.

Cloning of short hairpin RNAs for gene knockdown in mammalian cells.

Paddison PJ, Cleary M, Silva JM, Chang K, Sheth N, Sachidanandam R, Hannon GJ.

Nat Methods. 2004 Nov;1(2):163-7. No abstract available.

PMID:
16144086
[PubMed - indexed for MEDLINE]
12.

Production of complex nucleic acid libraries using highly parallel in situ oligonucleotide synthesis.

Cleary MA, Kilian K, Wang Y, Bradshaw J, Cavet G, Ge W, Kulkarni A, Paddison PJ, Chang K, Sheth N, Leproust E, Coffey EM, Burchard J, McCombie WR, Linsley P, Hannon GJ.

Nat Methods. 2004 Dec;1(3):241-8. Epub 2004 Nov 18.

PMID:
15782200
[PubMed - indexed for MEDLINE]
13.

A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites.

Du Q, Thonberg H, Wang J, Wahlestedt C, Liang Z.

Nucleic Acids Res. 2005 Mar 21;33(5):1671-7. Print 2005. Erratum in: Nucleic Acids Res. 2005;33(11):3698.

PMID:
15781493
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Cre-lox-regulated conditional RNA interference from transgenes.

Ventura A, Meissner A, Dillon CP, McManus M, Sharp PA, Van Parijs L, Jaenisch R, Jacks T.

Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10380-5. Epub 2004 Jul 6.

PMID:
15240889
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Specificity of microRNA target selection in translational repression.

Doench JG, Sharp PA.

Genes Dev. 2004 Mar 1;18(5):504-11. Epub 2004 Mar 10.

PMID:
15014042
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Rational siRNA design for RNA interference.

Reynolds A, Leake D, Boese Q, Scaringe S, Marshall WS, Khvorova A.

Nat Biotechnol. 2004 Mar;22(3):326-30. Epub 2004 Feb 1.

PMID:
14758366
[PubMed - indexed for MEDLINE]
Free Article
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