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Results: 1 to 20 of 57

1.

Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study.

Calton MA, Ersoy BA, Zhang S, Kane JP, Malloy MJ, Pullinger CR, Bromberg Y, Pennacchio LA, Dent R, McPherson R, Ahituv N, Vaisse C.

Hum Mol Genet. 2009 Mar 15;18(6):1140-7. doi: 10.1093/hmg/ddn431. Epub 2008 Dec 17.

PMID:
19091795
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor.

Tan K, Pogozheva ID, Yeo GS, Hadaschik D, Keogh JM, Haskell-Leuvano C, O'Rahilly S, Mosberg HI, Farooqi IS.

Endocrinology. 2009 Jan;150(1):114-25. doi: 10.1210/en.2008-0721. Epub 2008 Sep 18.

PMID:
18801902
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

SNAP predicts effect of mutations on protein function.

Bromberg Y, Yachdav G, Rost B.

Bioinformatics. 2008 Oct 15;24(20):2397-8. doi: 10.1093/bioinformatics/btn435. Epub 2008 Aug 30.

PMID:
18757876
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Comprehensive in silico mutagenesis highlights functionally important residues in proteins.

Bromberg Y, Rost B.

Bioinformatics. 2008 Aug 15;24(16):i207-12. doi: 10.1093/bioinformatics/btn268.

PMID:
18689826
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Role of third intracellular loop of the melanocortin 4 receptor in the regulation of constitutive activity.

Kim DH, Shin SW, Baik JH.

Biochem Biophys Res Commun. 2008 Jan 18;365(3):439-45. Epub 2007 Nov 5.

PMID:
17986382
[PubMed - indexed for MEDLINE]
6.

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.

Rasmussen SG, Choi HJ, Rosenbaum DM, Kobilka TS, Thian FS, Edwards PC, Burghammer M, Ratnala VR, Sanishvili R, Fischetti RF, Schertler GF, Weis WI, Kobilka BK.

Nature. 2007 Nov 15;450(7168):383-7. Epub 2007 Oct 21.

PMID:
17952055
[PubMed - indexed for MEDLINE]
7.

Critical assessment of methods of protein structure prediction-Round VII.

Moult J, Fidelis K, Kryshtafovych A, Rost B, Hubbard T, Tramontano A.

Proteins. 2007;69 Suppl 8:3-9.

PMID:
17918729
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Contribution of the conserved amino acids of the melanocortin-4 receptor in [corrected] [Nle4,D-Phe7]-alpha-melanocyte-stimulating [corrected] hormone binding and signaling.

Chen M, Cai M, Aprahamian CJ, Georgeson KE, Hruby V, Harmon CM, Yang Y.

J Biol Chem. 2007 Jul 27;282(30):21712-9. Epub 2007 Jun 1. Erratum in: J Biol Chem. 2007 Nov 16;282(46):33896.

PMID:
17545153
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

SNAP: predict effect of non-synonymous polymorphisms on function.

Bromberg Y, Rost B.

Nucleic Acids Res. 2007;35(11):3823-35. Epub 2007 May 25.

PMID:
17526529
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Structural and signaling requirements of the human melanocortin 4 receptor for MAP kinase activation.

Patten CS, Daniels D, Suzuki A, Fluharty SJ, Yee DK.

Regul Pept. 2007 Aug 16;142(3):111-22. Epub 2007 Feb 23.

PMID:
17376547
[PubMed - indexed for MEDLINE]
11.

Membrane protein prediction methods.

Punta M, Forrest LR, Bigelow H, Kernytsky A, Liu J, Rost B.

Methods. 2007 Apr;41(4):460-74. Review.

PMID:
17367718
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Constitutive traffic of melanocortin-4 receptor in Neuro2A cells and immortalized hypothalamic neurons.

Mohammad S, Baldini G, Granell S, Narducci P, Martelli AM, Baldini G.

J Biol Chem. 2007 Feb 16;282(7):4963-74. Epub 2006 Dec 12.

PMID:
17166828
[PubMed - indexed for MEDLINE]
Free Article
13.

Variations of the melanocortin-1 receptor and the glutathione-S transferase T1 and M1 genes in cutaneous malignant melanoma.

Mössner R, Anders N, König IR, Krüger U, Schmidt D, Berking C, Ziegler A, Brockmöller J, Kaiser R, Volkenandt M, Westphal GA, Reich K.

Arch Dermatol Res. 2007 Jan;298(8):371-9. Epub 2006 Oct 28.

PMID:
17072629
[PubMed - indexed for MEDLINE]
14.

Molecular basis of melanocortin-4 receptor for AGRP inverse agonism.

Chen M, Celik A, Georgeson KE, Harmon CM, Yang Y.

Regul Pept. 2006 Sep 11;136(1-3):40-9. Epub 2006 Jul 3.

PMID:
16820227
[PubMed - indexed for MEDLINE]
15.

Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist.

Xiang Z, Litherland SA, Sorensen NB, Proneth B, Wood MS, Shaw AM, Millard WJ, Haskell-Luevano C.

Biochemistry. 2006 Jun 13;45(23):7277-88.

PMID:
16752916
[PubMed - indexed for MEDLINE]
16.

Inactivating mutations of G protein-coupled receptors and diseases: structure-function insights and therapeutic implications.

Tao YX.

Pharmacol Ther. 2006 Sep;111(3):949-73. Epub 2006 Apr 17. Review.

PMID:
16616374
[PubMed - indexed for MEDLINE]
17.

Activation of the melanocortin-4 receptor mobilizes intracellular free calcium in immortalized hypothalamic neurons.

Newman EA, Chai BX, Zhang W, Li JY, Ammori JB, Mulholland MW.

J Surg Res. 2006 May 15;132(2):201-7. Epub 2006 Mar 31.

PMID:
16580690
[PubMed - indexed for MEDLINE]
18.

Beyond annotation transfer by homology: novel protein-function prediction methods to assist drug discovery.

Ofran Y, Punta M, Schneider R, Rost B.

Drug Discov Today. 2005 Nov 1;10(21):1475-82. Review.

PMID:
16243268
[PubMed - indexed for MEDLINE]
19.

Obesity-associated mutations in the melanocortin 4 receptor provide novel insights into its function.

Govaerts C, Srinivasan S, Shapiro A, Zhang S, Picard F, Clement K, Lubrano-Berthelier C, Vaisse C.

Peptides. 2005 Oct;26(10):1909-19. Review.

PMID:
16083993
[PubMed - indexed for MEDLINE]
20.

Functional analyses of melanocortin-4 receptor mutations identified from patients with binge eating disorder and nonobese or obese subjects.

Tao YX, Segaloff DL.

J Clin Endocrinol Metab. 2005 Oct;90(10):5632-8. Epub 2005 Jul 19.

PMID:
16030156
[PubMed - indexed for MEDLINE]

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