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Items: 1 to 20 of 25

1.

Linking SNPs to CAG repeat length in Huntington's disease patients.

Liu W, Kennington LA, Rosas HD, Hersch S, Cha JH, Zamore PD, Aronin N.

Nat Methods. 2008 Nov;5(11):951-3. doi: 10.1038/nmeth.1261. Epub 2008 Oct 19.

2.

Identification and allele-specific silencing of the mutant huntingtin allele in Huntington's disease patient-derived fibroblasts.

van Bilsen PH, Jaspers L, Lombardi MS, Odekerken JC, Burright EN, Kaemmerer WF.

Hum Gene Ther. 2008 Jul;19(7):710-9. doi: 10.1089/hum.2007.116.

PMID:
18549309
3.

Enhancement of allele discrimination by introduction of nucleotide mismatches into siRNA in allele-specific gene silencing by RNAi.

Ohnishi Y, Tamura Y, Yoshida M, Tokunaga K, Hohjoh H.

PLoS One. 2008 May 21;3(5):e2248. doi: 10.1371/journal.pone.0002248.

4.

Analysis of siRNA specificity on targets with double-nucleotide mismatches.

Dahlgren C, Zhang HY, Du Q, Grahn M, Norstedt G, Wahlestedt C, Liang Z.

Nucleic Acids Res. 2008 May;36(9):e53. doi: 10.1093/nar/gkn190. Epub 2008 Apr 17.

5.

Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits.

DiFiglia M, Sena-Esteves M, Chase K, Sapp E, Pfister E, Sass M, Yoder J, Reeves P, Pandey RK, Rajeev KG, Manoharan M, Sah DW, Zamore PD, Aronin N.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17204-9. Epub 2007 Oct 16.

6.

Designing siRNA that distinguish between genes that differ by a single nucleotide.

Schwarz DS, Ding H, Kennington L, Moore JT, Schelter J, Burchard J, Linsley PS, Aronin N, Xu Z, Zamore PD.

PLoS Genet. 2006 Sep 8;2(9):e140. Epub 2006 Jul 24.

7.

Allele-specific RNAi selectively silences mutant SOD1 and achieves significant therapeutic benefit in vivo.

Xia X, Zhou H, Huang Y, Xu Z.

Neurobiol Dis. 2006 Sep;23(3):578-86. Epub 2006 Jul 20.

PMID:
16857362
8.

Determinants of specific RNA interference-mediated silencing of human beta-globin alleles differing by a single nucleotide polymorphism.

Dykxhoorn DM, Schlehuber LD, London IM, Lieberman J.

Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5953-8. Epub 2006 Apr 3.

9.

rAAV-mediated shRNA ameliorated neuropathology in Huntington disease model mouse.

Machida Y, Okada T, Kurosawa M, Oyama F, Ozawa K, Nukina N.

Biochem Biophys Res Commun. 2006 Apr 28;343(1):190-7. Epub 2006 Mar 3.

PMID:
16530728
10.

Normal huntingtin function: an alternative approach to Huntington's disease.

Cattaneo E, Zuccato C, Tartari M.

Nat Rev Neurosci. 2005 Dec;6(12):919-30. Review.

PMID:
16288298
11.

Clinico-pathological rescue of a model mouse of Huntington's disease by siRNA.

Wang YL, Liu W, Wada E, Murata M, Wada K, Kanazawa I.

Neurosci Res. 2005 Nov;53(3):241-9. Epub 2005 Aug 10.

PMID:
16095740
12.

RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model.

Harper SQ, Staber PD, He X, Eliason SL, Martins IH, Mao Q, Yang L, Kotin RM, Paulson HL, Davidson BL.

Proc Natl Acad Sci U S A. 2005 Apr 19;102(16):5820-5. Epub 2005 Apr 5.

13.

A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites.

Du Q, Thonberg H, Wang J, Wahlestedt C, Liang Z.

Nucleic Acids Res. 2005 Mar 21;33(5):1671-7. Print 2005. Erratum in: Nucleic Acids Res. 2005;33(11):3698.

14.

Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model.

Ralph GS, Radcliffe PA, Day DM, Carthy JM, Leroux MA, Lee DC, Wong LF, Bilsland LG, Greensmith L, Kingsman SM, Mitrophanous KA, Mazarakis ND, Azzouz M.

Nat Med. 2005 Apr;11(4):429-33. Epub 2005 Mar 13.

15.

Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.

Raoul C, Abbas-Terki T, Bensadoun JC, Guillot S, Haase G, Szulc J, Henderson CE, Aebischer P.

Nat Med. 2005 Apr;11(4):423-8. Epub 2005 Mar 13.

16.

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

Xia H, Mao Q, Eliason SL, Harper SQ, Martins IH, Orr HT, Paulson HL, Yang L, Kotin RM, Davidson BL.

Nat Med. 2004 Aug;10(8):816-20. Epub 2004 Jul 4.

PMID:
15235598
17.

A SNP-centric database for the investigation of the human genome.

Riva A, Kohane IS.

BMC Bioinformatics. 2004 Mar 26;5:33. Review.

18.

Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles.

Miller VM, Gouvion CM, Davidson BL, Paulson HL.

Nucleic Acids Res. 2004 Jan 30;32(2):661-8. Print 2004.

19.

Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis.

Ding H, Schwarz DS, Keene A, Affar el B, Fenton L, Xia X, Shi Y, Zamore PD, Xu Z.

Aging Cell. 2003 Aug;2(4):209-17.

PMID:
12934714
20.

SNPper: retrieval and analysis of human SNPs.

Riva A, Kohane IS.

Bioinformatics. 2002 Dec;18(12):1681-5.

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