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Items: 1 to 20 of 64

1.

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange.

Liu Y, Dentin R, Chen D, Hedrick S, Ravnskjaer K, Schenk S, Milne J, Meyers DJ, Cole P, Yates J 3rd, Olefsky J, Guarente L, Montminy M.

Nature. 2008 Nov 13;456(7219):269-73. doi: 10.1038/nature07349. Epub 2008 Oct 5.

2.

SirT1 gain of function increases energy efficiency and prevents diabetes in mice.

Banks AS, Kon N, Knight C, Matsumoto M, Gutiérrez-Juárez R, Rossetti L, Gu W, Accili D.

Cell Metab. 2008 Oct;8(4):333-41. doi: 10.1016/j.cmet.2008.08.014.

3.

Chromatin remodeling, metabolism and circadian clocks: the interplay of CLOCK and SIRT1.

Grimaldi B, Nakahata Y, Kaluzova M, Masubuchi S, Sassone-Corsi P.

Int J Biochem Cell Biol. 2009 Jan;41(1):81-6. doi: 10.1016/j.biocel.2008.08.035. Epub 2008 Sep 4. Review.

PMID:
18817890
4.

Genome-wide coactivation analysis of PGC-1alpha identifies BAF60a as a regulator of hepatic lipid metabolism.

Li S, Liu C, Li N, Hao T, Han T, Hill DE, Vidal M, Lin JD.

Cell Metab. 2008 Aug;8(2):105-17. doi: 10.1016/j.cmet.2008.06.013.

5.

The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control.

Nakahata Y, Kaluzova M, Grimaldi B, Sahar S, Hirayama J, Chen D, Guarente LP, Sassone-Corsi P.

Cell. 2008 Jul 25;134(2):329-40. doi: 10.1016/j.cell.2008.07.002.

6.

Sirt1 protects against high-fat diet-induced metabolic damage.

Pfluger PT, Herranz D, Velasco-Miguel S, Serrano M, Tschöp MH.

Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9793-8. doi: 10.1073/pnas.0802917105. Epub 2008 Jul 3.

7.

Tissue-specific regulation of SIRT1 by calorie restriction.

Chen D, Bruno J, Easlon E, Lin SJ, Cheng HL, Alt FW, Guarente L.

Genes Dev. 2008 Jul 1;22(13):1753-7. doi: 10.1101/gad.1650608. Epub 2008 Jun 11.

8.

Comprehensive analysis of PPARalpha-dependent regulation of hepatic lipid metabolism by expression profiling.

Rakhshandehroo M, Sanderson LM, Matilainen M, Stienstra R, Carlberg C, de Groot PJ, Müller M, Kersten S.

PPAR Res. 2007;2007:26839. doi: 10.1155/2007/26839.

9.

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.

Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH.

Nature. 2007 Nov 29;450(7170):712-6.

10.

SIRT1 deacetylates and positively regulates the nuclear receptor LXR.

Li X, Zhang S, Blander G, Tse JG, Krieger M, Guarente L.

Mol Cell. 2007 Oct 12;28(1):91-106.

11.

Genetic links between diet and lifespan: shared mechanisms from yeast to humans.

Bishop NA, Guarente L.

Nat Rev Genet. 2007 Nov;8(11):835-44. Review.

PMID:
17909538
12.

Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1.

Rodgers JT, Puigserver P.

Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12861-6. Epub 2007 Jul 23.

13.

Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states.

Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E.

Cell Metab. 2007 Jun;5(6):426-37.

14.

Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21.

Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA.

Cell Metab. 2007 Jun;5(6):415-25.

15.

Peroxisome proliferator-activated receptor alpha protects against obesity-induced hepatic inflammation.

Stienstra R, Mandard S, Patsouris D, Maass C, Kersten S, Müller M.

Endocrinology. 2007 Jun;148(6):2753-63. Epub 2007 Mar 8.

PMID:
17347305
16.

Sirtuins as potential targets for metabolic syndrome.

Guarente L.

Nature. 2006 Dec 14;444(7121):868-74. Review.

PMID:
17167475
17.

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.

Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J.

Cell. 2006 Dec 15;127(6):1109-22. Epub 2006 Nov 16.

18.

Resveratrol improves health and survival of mice on a high-calorie diet.

Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA.

Nature. 2006 Nov 16;444(7117):337-42. Epub 2006 Nov 1.

PMID:
17086191
19.

Nuclear receptor expression links the circadian clock to metabolism.

Yang X, Downes M, Yu RT, Bookout AL, He W, Straume M, Mangelsdorf DJ, Evans RM.

Cell. 2006 Aug 25;126(4):801-10.

20.

MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity.

Kanda H, Tateya S, Tamori Y, Kotani K, Hiasa K, Kitazawa R, Kitazawa S, Miyachi H, Maeda S, Egashira K, Kasuga M.

J Clin Invest. 2006 Jun;116(6):1494-505. Epub 2006 May 11.

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