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Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery.

Macůrek L, Lindqvist A, Lim D, Lampson MA, Klompmaker R, Freire R, Clouin C, Taylor SS, Yaffe MB, Medema RH.

Nature. 2008 Sep 4;455(7209):119-23. doi: 10.1038/nature07185. Epub 2008 Jul 9.


Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry.

Seki A, Coppinger JA, Jang CY, Yates JR, Fang G.

Science. 2008 Jun 20;320(5883):1655-8. doi: 10.1126/science.1157425.


Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora.

Chan EH, Santamaria A, Silljé HH, Nigg EA.

Chromosoma. 2008 Oct;117(5):457-69. doi: 10.1007/s00412-008-0165-5. Epub 2008 Jun 3.


Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression.

Seki A, Coppinger JA, Du H, Jang CY, Yates JR 3rd, Fang G.

J Cell Biol. 2008 Apr 7;181(1):65-78. doi: 10.1083/jcb.200712027. Epub 2008 Mar 31.


Polo-box domains confer target specificity to the Polo-like kinase family.

van de Weerdt BC, Littler DR, Klompmaker R, Huseinovic A, Fish A, Perrakis A, Medema RH.

Biochim Biophys Acta. 2008 Jun;1783(6):1015-22. doi: 10.1016/j.bbamcr.2008.02.019. Epub 2008 Mar 5.


Mechanisms of mammalian polo-like kinase 1 (Plk1) localization: self- versus non-self-priming.

Lee KS, Park JE, Kang YH, Zimmerman W, Soung NK, Seong YS, Kwak SJ, Erikson RL.

Cell Cycle. 2008 Jan 15;7(2):141-5. Epub 2007 Oct 16.


Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis.

Santamaria A, Neef R, Eberspächer U, Eis K, Husemann M, Mumberg D, Prechtl S, Schulze V, Siemeister G, Wortmann L, Barr FA, Nigg EA.

Mol Biol Cell. 2007 Oct;18(10):4024-36. Epub 2007 Aug 1.


Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate.

Lowery DM, Clauser KR, Hjerrild M, Lim D, Alexander J, Kishi K, Ong SE, Gammeltoft S, Carr SA, Yaffe MB.

EMBO J. 2007 May 2;26(9):2262-73. Epub 2007 Apr 19.


Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1.

Neef R, Gruneberg U, Kopajtich R, Li X, Nigg EA, Sillje H, Barr FA.

Nat Cell Biol. 2007 Apr;9(4):436-44. Epub 2007 Mar 11.


Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization.

García-Alvarez B, de Cárcer G, Ibañez S, Bragado-Nilsson E, Montoya G.

Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3107-12. Epub 2007 Feb 16.


The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1.

Lénárt P, Petronczki M, Steegmaier M, Di Fiore B, Lipp JJ, Hoffmann M, Rettig WJ, Kraut N, Peters JM.

Curr Biol. 2007 Feb 20;17(4):304-15. Epub 2007 Feb 8.


Centrosomal localization of DNA damage checkpoint proteins.

Zhang S, Hemmerich P, Grosse F.

J Cell Biochem. 2007 May 15;101(2):451-65.


Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation.

Kang YH, Park JE, Yu LR, Soung NK, Yun SM, Bang JK, Seong YS, Yu H, Garfield S, Veenstra TD, Lee KS.

Mol Cell. 2006 Nov 3;24(3):409-22.


The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity.

Oshimori N, Ohsugi M, Yamamoto T.

Nat Cell Biol. 2006 Oct;8(10):1095-101. Epub 2006 Sep 17.


Requirement of hCenexin for proper mitotic functions of polo-like kinase 1 at the centrosomes.

Soung NK, Kang YH, Kim K, Kamijo K, Yoon H, Seong YS, Kuo YL, Miki T, Kim SR, Kuriyama R, Giam CZ, Ahn CH, Lee KS.

Mol Cell Biol. 2006 Nov;26(22):8316-35. Epub 2006 Sep 11.


Tetrameric hub structure of postsynaptic scaffolding protein homer.

Hayashi MK, Ames HM, Hayashi Y.

J Neurosci. 2006 Aug 16;26(33):8492-501.


Structure meets function--centrosomes, genome maintenance and the DNA damage response.

Löffler H, Lukas J, Bartek J, Krämer A.

Exp Cell Res. 2006 Aug 15;312(14):2633-40. Epub 2006 Jun 20. Review.


Normal cells, but not cancer cells, survive severe Plk1 depletion.

Liu X, Lei M, Erikson RL.

Mol Cell Biol. 2006 Mar;26(6):2093-108.

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