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Items: 1 to 20 of 34

1.

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling.

Ikenoue T, Inoki K, Yang Q, Zhou X, Guan KL.

EMBO J. 2008 Jul 23;27(14):1919-31. doi: 10.1038/emboj.2008.119. Epub 2008 Jun 19. Erratum in: EMBO J. 2008 Aug 20;27(16):2270.

2.

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C.

Facchinetti V, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C, Lowry C, Newton AC, Mao Y, Miao RQ, Sessa WC, Qin J, Zhang P, Su B, Jacinto E.

EMBO J. 2008 Jul 23;27(14):1932-43. doi: 10.1038/emboj.2008.120. Epub 2008 Jun 19.

3.

The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.

Huang J, Manning BD.

Biochem J. 2008 Jun 1;412(2):179-90. doi: 10.1042/BJ20080281. Review.

4.

PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival.

Bozulic L, Surucu B, Hynx D, Hemmings BA.

Mol Cell. 2008 Apr 25;30(2):203-13. doi: 10.1016/j.molcel.2008.02.024.

5.

The TSC1-TSC2 complex is required for proper activation of mTOR complex 2.

Huang J, Dibble CC, Matsuzaki M, Manning BD.

Mol Cell Biol. 2008 Jun;28(12):4104-15. doi: 10.1128/MCB.00289-08. Epub 2008 Apr 14.

6.

FOXO-regulated transcription restricts overgrowth of Tsc mutant organs.

Harvey KF, Mattila J, Sofer A, Bennett FC, Ramsey MR, Ellisen LW, Puig O, Hariharan IK.

J Cell Biol. 2008 Feb 25;180(4):691-6. doi: 10.1083/jcb.200710100.

7.

Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling.

DeYoung MP, Horak P, Sofer A, Sgroi D, Ellisen LW.

Genes Dev. 2008 Jan 15;22(2):239-51. doi: 10.1101/gad.1617608.

8.

AKT/PKB signaling: navigating downstream.

Manning BD, Cantley LC.

Cell. 2007 Jun 29;129(7):1261-74. Review.

9.

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.

Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM.

Dev Cell. 2006 Dec;11(6):859-71.

10.

S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt.

Zhang HH, Lipovsky AI, Dibble CC, Sahin M, Manning BD.

Mol Cell. 2006 Oct 20;24(2):185-97.

11.

The tuberous sclerosis complex.

Crino PB, Nathanson KL, Henske EP.

N Engl J Med. 2006 Sep 28;355(13):1345-56. Review. No abstract available.

PMID:
17005952
12.

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s.

Frias MA, Thoreen CC, Jaffe JD, Schroder W, Sculley T, Carr SA, Sabatini DM.

Curr Biol. 2006 Sep 19;16(18):1865-70. Epub 2006 Aug 17.

13.

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.

Engelman JA, Luo J, Cantley LC.

Nat Rev Genet. 2006 Aug;7(8):606-19. Review.

PMID:
16847462
14.

Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning.

Cai SL, Tee AR, Short JD, Bergeron JM, Kim J, Shen J, Guo R, Johnson CL, Kiguchi K, Walker CL.

J Cell Biol. 2006 Apr 24;173(2):279-89.

15.

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.

Sarbassov DD, Ali SM, Sengupta S, Sheen JH, Hsu PP, Bagley AF, Markhard AL, Sabatini DM.

Mol Cell. 2006 Apr 21;22(2):159-68. Epub 2006 Apr 6.

16.

TOR signaling in growth and metabolism.

Wullschleger S, Loewith R, Hall MN.

Cell. 2006 Feb 10;124(3):471-84. Review.

17.

Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2.

Manning BD, Logsdon MN, Lipovsky AI, Abbott D, Kwiatkowski DJ, Cantley LC.

Genes Dev. 2005 Aug 1;19(15):1773-8. Epub 2005 Jul 18.

18.

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.

Sarbassov DD, Guertin DA, Ali SM, Sabatini DM.

Science. 2005 Feb 18;307(5712):1098-101.

19.

Restraining PI3K: mTOR signalling goes back to the membrane.

Harrington LS, Findlay GM, Lamb RF.

Trends Biochem Sci. 2005 Jan;30(1):35-42. Review.

PMID:
15653324
20.

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis.

Manning BD.

J Cell Biol. 2004 Nov 8;167(3):399-403. Review. Erratum in: J Cell Biol. 2004 Dec 20;167(6):1255.

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