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Results: 1 to 20 of 36

1.

PIK3CA mutations and copy number gains in human lung cancers.

Yamamoto H, Shigematsu H, Nomura M, Lockwood WW, Sato M, Okumura N, Soh J, Suzuki M, Wistuba II, Fong KM, Lee H, Toyooka S, Date H, Lam WL, Minna JD, Gazdar AF.

Cancer Res. 2008 Sep 1;68(17):6913-21. doi: 10.1158/0008-5472.CAN-07-5084.

PMID:
18757405
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Knock-in of oncogenic Kras does not transform mouse somatic cells but triggers a transcriptional response that classifies human cancers.

Arena S, Isella C, Martini M, de Marco A, Medico E, Bardelli A.

Cancer Res. 2007 Sep 15;67(18):8468-76.

PMID:
17875685
[PubMed - indexed for MEDLINE]
Free Article
3.

Knock-in of mutant K-ras in nontumorigenic human epithelial cells as a new model for studying K-ras mediated transformation.

Konishi H, Karakas B, Abukhdeir AM, Lauring J, Gustin JP, Garay JP, Konishi Y, Gallmeier E, Bachman KE, Park BH.

Cancer Res. 2007 Sep 15;67(18):8460-7.

PMID:
17875684
[PubMed - indexed for MEDLINE]
Free Article
4.

Etiologic impact of known cancer susceptibility genes.

Hemminki K, Försti A, Lorenzo Bermejo J.

Mutat Res. 2008 Jan-Feb;658(1-2):42-54. Epub 2007 Aug 1. Review.

PMID:
17827054
[PubMed - indexed for MEDLINE]
5.

Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes.

Ince TA, Richardson AL, Bell GW, Saitoh M, Godar S, Karnoub AE, Iglehart JD, Weinberg RA.

Cancer Cell. 2007 Aug;12(2):160-70.

PMID:
17692807
[PubMed - indexed for MEDLINE]
Free Article
6.

Genetic targeting of the kinase activity of the Met receptor in cancer cells.

Arena S, Pisacane A, Mazzone M, Comoglio PM, Bardelli A.

Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11412-7. Epub 2007 Jun 26.

PMID:
17595299
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity.

Vikis H, Sato M, James M, Wang D, Wang Y, Wang M, Jia D, Liu Y, Bailey-Wilson JE, Amos CI, Pinney SM, Petersen GM, de Andrade M, Yang P, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Gaba C, Rothschild H, Mandal D, Kupert E, Seminara D, Viswanathan A, Govindan R, Minna J, Anderson MW, You M.

Cancer Res. 2007 May 15;67(10):4665-70.

PMID:
17510392
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling.

Shtiegman K, Kochupurakkal BS, Zwang Y, Pines G, Starr A, Vexler A, Citri A, Katz M, Lavi S, Ben-Basat Y, Benjamin S, Corso S, Gan J, Yosef RB, Giordano S, Yarden Y.

Oncogene. 2007 Oct 25;26(49):6968-78. Epub 2007 May 7.

PMID:
17486068
[PubMed - indexed for MEDLINE]
9.

Gefitinib-sensitive EGFR lacking residues 746-750 exhibits hypophosphorylation at tyrosine residue 1045, hypoubiquitination, and impaired endocytosis.

Furukawa M, Nagatomo I, Kumagai T, Yamadori T, Takahashi R, Yoshimura M, Yoneda T, Takeda Y, Goya S, Matsuoka H, Kijima T, Yoshida M, Osaki T, Tachibana I, Greene MI, Kawase I.

DNA Cell Biol. 2007 Mar;26(3):178-85.

PMID:
17417946
[PubMed - indexed for MEDLINE]
10.

Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies.

Benvenuti S, Sartore-Bianchi A, Di Nicolantonio F, Zanon C, Moroni M, Veronese S, Siena S, Bardelli A.

Cancer Res. 2007 Mar 15;67(6):2643-8.

PMID:
17363584
[PubMed - indexed for MEDLINE]
Free Article
11.

K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling.

Campbell PM, Groehler AL, Lee KM, Ouellette MM, Khazak V, Der CJ.

Cancer Res. 2007 Mar 1;67(5):2098-106.

PMID:
17332339
[PubMed - indexed for MEDLINE]
Free Article
12.

Differential constitutive activation of the epidermal growth factor receptor in non-small cell lung cancer cells bearing EGFR gene mutation and amplification.

Okabe T, Okamoto I, Tamura K, Terashima M, Yoshida T, Satoh T, Takada M, Fukuoka M, Nakagawa K.

Cancer Res. 2007 Mar 1;67(5):2046-53.

PMID:
17332333
[PubMed - indexed for MEDLINE]
Free Article
13.

PTEN-mediated resistance to epidermal growth factor receptor kinase inhibitors.

Mellinghoff IK, Cloughesy TF, Mischel PS.

Clin Cancer Res. 2007 Jan 15;13(2 Pt 1):378-81. Review.

PMID:
17255257
[PubMed - indexed for MEDLINE]
Free Article
14.

FLAME, a novel fuzzy clustering method for the analysis of DNA microarray data.

Fu L, Medico E.

BMC Bioinformatics. 2007 Jan 4;8:3.

PMID:
17204155
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib.

Carey KD, Garton AJ, Romero MS, Kahler J, Thomson S, Ross S, Park F, Haley JD, Gibson N, Sliwkowski MX.

Cancer Res. 2006 Aug 15;66(16):8163-71.

PMID:
16912195
[PubMed - indexed for MEDLINE]
Free Article
16.

Functional analysis of the regulatory requirements of B-Raf and the B-Raf(V600E) oncoprotein.

Brummer T, Martin P, Herzog S, Misawa Y, Daly RJ, Reth M.

Oncogene. 2006 Oct 12;25(47):6262-76. Epub 2006 May 15.

PMID:
16702958
[PubMed - indexed for MEDLINE]
17.

Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells.

Sato M, Vaughan MB, Girard L, Peyton M, Lee W, Shames DS, Ramirez RD, Sunaga N, Gazdar AF, Shay JW, Minna JD.

Cancer Res. 2006 Feb 15;66(4):2116-28.

PMID:
16489012
[PubMed - indexed for MEDLINE]
Free Article
18.

Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells.

Isakoff SJ, Engelman JA, Irie HY, Luo J, Brachmann SM, Pearline RV, Cantley LC, Brugge JS.

Cancer Res. 2005 Dec 1;65(23):10992-1000.

PMID:
16322248
[PubMed - indexed for MEDLINE]
Free Article
19.

Mutant PIK3CA promotes cell growth and invasion of human cancer cells.

Samuels Y, Diaz LA Jr, Schmidt-Kittler O, Cummins JM, Delong L, Cheong I, Rago C, Huso DL, Lengauer C, Kinzler KW, Vogelstein B, Velculescu VE.

Cancer Cell. 2005 Jun;7(6):561-73.

PMID:
15950905
[PubMed - indexed for MEDLINE]
Free Article
20.

Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and non-small-cell lung cancer: current knowledge and future directions.

Pao W, Miller VA.

J Clin Oncol. 2005 Apr 10;23(11):2556-68. Epub 2005 Mar 14. Review.

PMID:
15767641
[PubMed - indexed for MEDLINE]
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