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Items: 1 to 20 of 31

1.

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration.

Zhong Z, Deane R, Ali Z, Parisi M, Shapovalov Y, O'Banion MK, Stojanovic K, Sagare A, Boillee S, Cleveland DW, Zlokovic BV.

Nat Neurosci. 2008 Apr;11(4):420-2. doi: 10.1038/nn2073. Epub 2008 Mar 16.

2.

Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets.

Han MH, Hwang SI, Roy DB, Lundgren DH, Price JV, Ousman SS, Fernald GH, Gerlitz B, Robinson WH, Baranzini SE, Grinnell BW, Raine CS, Sobel RA, Han DK, Steinman L.

Nature. 2008 Feb 28;451(7182):1076-81. doi: 10.1038/nature06559. Epub 2008 Feb 17.

PMID:
18278032
3.

Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis.

Isermann B, Vinnikov IA, Madhusudhan T, Herzog S, Kashif M, Blautzik J, Corat MA, Zeier M, Blessing E, Oh J, Gerlitz B, Berg DT, Grinnell BW, Chavakis T, Esmon CT, Weiler H, Bierhaus A, Nawroth PP.

Nat Med. 2007 Nov;13(11):1349-58. Epub 2007 Nov 4.

PMID:
17982464
4.

Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C.

Kerschen EJ, Fernandez JA, Cooley BC, Yang XV, Sood R, Mosnier LO, Castellino FJ, Mackman N, Griffin JH, Weiler H.

J Exp Med. 2007 Oct 1;204(10):2439-48. Epub 2007 Sep 24.

6.

The cytoprotective protein C pathway.

Mosnier LO, Zlokovic BV, Griffin JH.

Blood. 2007 Apr 15;109(8):3161-72. Epub 2006 Nov 16. Review.

7.

Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage.

Cheng T, Petraglia AL, Li Z, Thiyagarajan M, Zhong Z, Wu Z, Liu D, Maggirwar SB, Deane R, Fernández JA, LaRue B, Griffin JH, Chopp M, Zlokovic BV.

Nat Med. 2006 Nov;12(11):1278-85. Epub 2006 Oct 29.

PMID:
17072311
8.

Functional recovery after embolic stroke in rodents by activated protein C.

Zlokovic BV, Zhang C, Liu D, Fernandez J, Griffin JH, Chopp M.

Ann Neurol. 2005 Sep;58(3):474-7.

PMID:
16130108
9.

Effect of targeted deletion of the heme oxygenase-2 gene on hemoglobin toxicity in the striatum.

Qu Y, Chen J, Benvenisti-Zarom L, Ma X, Regan RF.

J Cereb Blood Flow Metab. 2005 Nov;25(11):1466-75.

10.
11.

Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C.

Liu D, Cheng T, Guo H, Fernández JA, Griffin JH, Song X, Zlokovic BV.

Nat Med. 2004 Dec;10(12):1379-83. Epub 2004 Oct 31.

PMID:
15516929
12.

Intracerebral hemorrhage: effects of aging on brain edema and neurological deficits.

Gong Y, Hua Y, Keep RF, Hoff JT, Xi G.

Stroke. 2004 Nov;35(11):2571-5. Epub 2004 Oct 7.

13.

Activated protein C variants with normal cytoprotective but reduced anticoagulant activity.

Mosnier LO, Gale AJ, Yegneswaran S, Griffin JH.

Blood. 2004 Sep 15;104(6):1740-4. Epub 2004 Jun 3.

14.

Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3.

Guo H, Liu D, Gelbard H, Cheng T, Insalaco R, Fernández JA, Griffin JH, Zlokovic BV.

Neuron. 2004 Feb 19;41(4):563-72.

16.

Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1.

Dömötör E, Benzakour O, Griffin JH, Yule D, Fukudome K, Zlokovic BV.

Blood. 2003 Jun 15;101(12):4797-801. Epub 2003 Feb 13.

17.

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective.

Cheng T, Liu D, Griffin JH, Fernández JA, Castellino F, Rosen ED, Fukudome K, Zlokovic BV.

Nat Med. 2003 Mar;9(3):338-42. Epub 2003 Feb 3.

PMID:
12563316
18.

Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke.

Griffin JH, Zlokovic B, Fernández JA.

Semin Hematol. 2002 Jul;39(3):197-205. Review.

PMID:
12124682
19.

Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C.

Gale AJ, Tsavaler A, Griffin JH.

J Biol Chem. 2002 Aug 9;277(32):28836-40. Epub 2002 Jun 12.

20.

Activation of endothelial cell protease activated receptor 1 by the protein C pathway.

Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W.

Science. 2002 Jun 7;296(5574):1880-2.

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