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Items: 1 to 20 of 39


Structures of the toll-like receptor family and its ligand complexes.

Jin MS, Lee JO.

Immunity. 2008 Aug 15;29(2):182-91. doi: 10.1016/j.immuni.2008.07.007. Review.


Structural basis of toll-like receptor 3 signaling with double-stranded RNA.

Liu L, Botos I, Wang Y, Leonard JN, Shiloach J, Segal DM, Davies DR.

Science. 2008 Apr 18;320(5874):379-81. doi: 10.1126/science.1155406.


UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes.

Kim YM, Brinkmann MM, Paquet ME, Ploegh HL.

Nature. 2008 Mar 13;452(7184):234-8. doi: 10.1038/nature06726. Epub 2008 Feb 27.


Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.

Asagiri M, Hirai T, Kunigami T, Kamano S, Gober HJ, Okamoto K, Nishikawa K, Latz E, Golenbock DT, Aoki K, Ohya K, Imai Y, Morishita Y, Miyazono K, Kato S, Saftig P, Takayanagi H.

Science. 2008 Feb 1;319(5863):624-7. doi: 10.1126/science.1150110.


Cathepsins are required for Toll-like receptor 9 responses.

Matsumoto F, Saitoh S, Fukui R, Kobayashi T, Tanimura N, Konno K, Kusumoto Y, Akashi-Takamura S, Miyake K.

Biochem Biophys Res Commun. 2008 Mar 14;367(3):693-9. doi: 10.1016/j.bbrc.2007.12.130. Epub 2007 Dec 31.


Cathepsin L activity controls adipogenesis and glucose tolerance.

Yang M, Zhang Y, Pan J, Sun J, Liu J, Libby P, Sukhova GK, Doria A, Katunuma N, Peroni OD, Guerre-Millo M, Kahn BB, Clement K, Shi GP.

Nat Cell Biol. 2007 Aug;9(8):970-7. Epub 2007 Jul 22.


The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling.

Brinkmann MM, Spooner E, Hoebe K, Beutler B, Ploegh HL, Kim YM.

J Cell Biol. 2007 Apr 23;177(2):265-75.


Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting.

Triantafilou M, Gamper FG, Haston RM, Mouratis MA, Morath S, Hartung T, Triantafilou K.

J Biol Chem. 2006 Oct 13;281(41):31002-11. Epub 2006 Jul 31.


TLR signaling.

Kawai T, Akira S.

Cell Death Differ. 2006 May;13(5):816-25. Review.


Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA.

Barton GM, Kagan JC, Medzhitov R.

Nat Immunol. 2006 Jan;7(1):49-56. Epub 2005 Dec 11.


TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements.

Nishiya T, Kajita E, Miwa S, Defranco AL.

J Biol Chem. 2005 Nov 4;280(44):37107-17. Epub 2005 Aug 16.


Crystal structure of human toll-like receptor 3 (TLR3) ectodomain.

Choe J, Kelker MS, Wilson IA.

Science. 2005 Jul 22;309(5734):581-5. Epub 2005 Jun 16.


Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice.

Maehr R, Hang HC, Mintern JD, Kim YM, Cuvillier A, Nishimura M, Yamada K, Shirahama-Noda K, Hara-Nishimura I, Ploegh HL.

J Immunol. 2005 Jun 1;174(11):7066-74.


Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins.

Rogers NC, Slack EC, Edwards AD, Nolte MA, Schulz O, Schweighoffer E, Williams DL, Gordon S, Tybulewicz VL, Brown GD, Reis e Sousa C.

Immunity. 2005 Apr;22(4):507-17. Erratum in: Immunity. 2005 Jun;22(6):773-4.


Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction.

Honda K, Ohba Y, Yanai H, Negishi H, Mizutani T, Takaoka A, Taya C, Taniguchi T.

Nature. 2005 Apr 21;434(7036):1035-40. Epub 2005 Apr 6.


Toll-like receptors in innate immunity.

Takeda K, Akira S.

Int Immunol. 2005 Jan;17(1):1-14. Review.


TLR9 is localized in the endoplasmic reticulum prior to stimulation.

Leifer CA, Kennedy MN, Mazzoni A, Lee C, Kruhlak MJ, Segal DM.

J Immunol. 2004 Jul 15;173(2):1179-83.


Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8.

Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, Lipford G, Wagner H, Bauer S.

Science. 2004 Mar 5;303(5663):1526-9. Epub 2004 Feb 19.


Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.

Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C.

Science. 2004 Mar 5;303(5663):1529-31. Epub 2004 Feb 19.


TLR9 signals after translocating from the ER to CpG DNA in the lysosome.

Latz E, Schoenemeyer A, Visintin A, Fitzgerald KA, Monks BG, Knetter CF, Lien E, Nilsen NJ, Espevik T, Golenbock DT.

Nat Immunol. 2004 Feb;5(2):190-8. Epub 2004 Jan 11.

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