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Items: 20


Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart.

Gross GJ, Gauthier KM, Moore J, Falck JR, Hammock BD, Campbell WB, Nithipatikom K.

Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2838-44. doi: 10.1152/ajpheart.00186.2008. Epub 2008 Apr 25.


Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia.

Zhang W, Otsuka T, Sugo N, Ardeshiri A, Alhadid YK, Iliff JJ, DeBarber AE, Koop DR, Alkayed NJ.

Stroke. 2008 Jul;39(7):2073-8. doi: 10.1161/STROKEAHA.107.508325. Epub 2008 Mar 27.


Myocardial reperfusion injury.

Yellon DM, Hausenloy DJ.

N Engl J Med. 2007 Sep 13;357(11):1121-35. Review. No abstract available.


Soluble epoxide hydrolase gene deletion reduces survival after cardiac arrest and cardiopulmonary resuscitation.

Hutchens MP, Nakano T, Dunlap J, Traystman RJ, Hurn PD, Alkayed NJ.

Resuscitation. 2008 Jan;76(1):89-94. Epub 2007 Aug 28.


A novel role for P450 eicosanoids in the neurogenic control of cerebral blood flow in the rat.

Iliff JJ, Close LN, Selden NR, Alkayed NJ.

Exp Physiol. 2007 Jul;92(4):653-8.


Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury.

Koerner IP, Jacks R, DeBarber AE, Koop D, Mao P, Grant DF, Alkayed NJ.

J Neurosci. 2007 Apr 25;27(17):4642-9.


Soluble epoxide hydrolase: a novel therapeutic target in stroke.

Zhang W, Koerner IP, Noppens R, Grafe M, Tsai HJ, Morisseau C, Luria A, Hammock BD, Falck JR, Alkayed NJ.

J Cereb Blood Flow Metab. 2007 Dec;27(12):1931-40. Epub 2007 Apr 18.


Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts.

Gross GJ, Hsu A, Falck JR, Nithipatikom K.

J Mol Cell Cardiol. 2007 Mar;42(3):687-91. Epub 2007 Jan 10.


Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function.

Seubert JM, Sinal CJ, Graves J, DeGraff LM, Bradbury JA, Lee CR, Goralski K, Carey MA, Luria A, Newman JW, Hammock BD, Falck JR, Roberts H, Rockman HA, Murphy E, Zeldin DC.

Circ Res. 2006 Aug 18;99(4):442-50. Epub 2006 Jul 20.


Epoxyeicosatrienoic acids in cardioprotection: ischemic versus reperfusion injury.

Nithipatikom K, Moore JM, Isbell MA, Falck JR, Gross GJ.

Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H537-42. Epub 2006 Feb 10.


Cell-specific subcellular localization of soluble epoxide hydrolase in human tissues.

Enayetallah AE, French RA, Barber M, Grant DF.

J Histochem Cytochem. 2006 Mar;54(3):329-35. Epub 2005 Nov 28.


Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles.

Morisseau C, Hammock BD.

Annu Rev Pharmacol Toxicol. 2005;45:311-33. Review.


Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels.

Fang X, Weintraub NL, McCaw RB, Hu S, Harmon SD, Rice JB, Hammock BD, Spector AA.

Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2412-20. Epub 2004 Jul 29.


Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway.

Seubert J, Yang B, Bradbury JA, Graves J, Degraff LM, Gabel S, Gooch R, Foley J, Newman J, Mao L, Rockman HA, Hammock BD, Murphy E, Zeldin DC.

Circ Res. 2004 Sep 3;95(5):506-14. Epub 2004 Jul 15.


Cytochrome P450 in neurological disease.

Liu M, Hurn PD, Alkayed NJ.

Curr Drug Metab. 2004 Jun;5(3):225-34. Review.


The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity.

Newman JW, Morisseau C, Harris TR, Hammock BD.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1558-63. Epub 2003 Feb 6.


Opioids and cardioprotection.

Schultz JE, Gross GJ.

Pharmacol Ther. 2001 Feb;89(2):123-37. Review.


Regio- and enantiofacial selectivity of epoxyeicosatrienoic acid hydration by cytosolic epoxide hydrolase.

Zeldin DC, Kobayashi J, Falck JR, Winder BS, Hammock BD, Snapper JR, Capdevila JH.

J Biol Chem. 1993 Mar 25;268(9):6402-7.

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