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Results: 1 to 20 of 62

References for PMC Articles for PubMed (Select 18755774)


mTOR signaling contributes to chondrocyte differentiation.

Phornphutkul C, Wu KY, Auyeung V, Chen Q, Gruppuso PA.

Dev Dyn. 2008 Mar;237(3):702-12. doi: 10.1002/dvdy.21464.


Chronic tumor necrosis factor-alpha treatment causes insulin resistance via insulin receptor substrate-1 serine phosphorylation and suppressor of cytokine signaling-3 induction in 3T3-L1 adipocytes.

Ishizuka K, Usui I, Kanatani Y, Bukhari A, He J, Fujisaka S, Yamazaki Y, Suzuki H, Hiratani K, Ishiki M, Iwata M, Urakaze M, Haruta T, Kobayashi M.

Endocrinology. 2007 Jun;148(6):2994-3003. Epub 2007 Mar 22.


Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2.

Dearth RK, Cui X, Kim HJ, Hadsell DL, Lee AV.

Cell Cycle. 2007 Mar 15;6(6):705-13. Epub 2007 Mar 20. Review.


Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2.

Dearth RK, Cui X, Kim HJ, Kuiatse I, Lawrence NA, Zhang X, Divisova J, Britton OL, Mohsin S, Allred DC, Hadsell DL, Lee AV.

Mol Cell Biol. 2006 Dec;26(24):9302-14. Epub 2006 Oct 9.


Constitutive activity of glycogen synthase kinase-3beta: positive regulation of steady-state levels of insulin receptor substrates-1 and -2 in adrenal chromaffin cells.

Nemoto T, Yokoo H, Satoh S, Yanagita T, Sugano T, Yoshikawa N, Maruta T, Kobayashi H, Wada A.

Brain Res. 2006 Sep 19;1110(1):1-12. Epub 2006 Jul 25.


The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation.

Corrales JD, Blaess S, Mahoney EM, Joyner AL.

Development. 2006 May;133(9):1811-21. Epub 2006 Mar 29.


Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling.

Riobó NA, Lu K, Ai X, Haines GM, Emerson CP Jr.

Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4505-10. Epub 2006 Mar 10.


IRS-1: auditing the effectiveness of mTOR inhibitors.

Easton JB, Kurmasheva RT, Houghton PJ.

Cancer Cell. 2006 Mar;9(3):153-5. Review.


Neural precursor cycling at sonic speed: N-Myc pedals, GSK-3 brakes.

Knoepfler PS, Kenney AM.

Cell Cycle. 2006 Jan;5(1):47-52. Epub 2006 Jan 1. Review.


The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation.

Uziel T, Zindy F, Xie S, Lee Y, Forget A, Magdaleno S, Rehg JE, Calabrese C, Solecki D, Eberhart CG, Sherr SE, Plimmer S, Clifford SC, Hatten ME, McKinnon PJ, Gilbertson RJ, Curran T, Sherr CJ, Roussel MF.

Genes Dev. 2005 Nov 15;19(22):2656-67. Epub 2005 Oct 31.


The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors.

Sjostrom SK, Finn G, Hahn WC, Rowitch DH, Kenney AM.

Dev Cell. 2005 Sep;9(3):327-38.


Shh controls epithelial proliferation via independent pathways that converge on N-Myc.

Mill P, Mo R, Hu MC, Dagnino L, Rosenblum ND, Hui CC.

Dev Cell. 2005 Aug;9(2):293-303.


Functional significance of type 1 insulin-like growth factor-mediated nuclear translocation of the insulin receptor substrate-1 and beta-catenin.

Chen J, Wu A, Sun H, Drakas R, Garofalo C, Cascio S, Surmacz E, Baserga R.

J Biol Chem. 2005 Aug 19;280(33):29912-20. Epub 2005 Jun 20.


Insulin receptor substrates-1 and -2 are both depleted but via different mechanisms after down-regulation of glucose transport in rat adipocytes.

Renström F, Burén J, Eriksson JW.

Endocrinology. 2005 Jul;146(7):3044-51. Epub 2005 Apr 21.


Insulin-like growth factor II is involved in the proliferation control of medulloblastoma and its cerebellar precursor cells.

Hartmann W, Koch A, Brune H, Waha A, Schüller U, Dani I, Denkhaus D, Langmann W, Bode U, Wiestler OD, Schilling K, Pietsch T.

Am J Pathol. 2005 Apr;166(4):1153-62.


Medulloblastoma: developmental mechanisms out of control.

Marino S.

Trends Mol Med. 2005 Jan;11(1):17-22. Review.


The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas.

Hallahan AR, Pritchard JI, Hansen S, Benson M, Stoeck J, Hatton BA, Russell TL, Ellenbogen RG, Bernstein ID, Beachy PA, Olson JM.

Cancer Res. 2004 Nov 1;64(21):7794-800.


Retinoic acid mediates degradation of IRS-1 by the ubiquitin-proteasome pathway, via a PKC-dependant mechanism.

del Rincón SV, Guo Q, Morelli C, Shiu HY, Surmacz E, Miller WH.

Oncogene. 2004 Dec 9;23(57):9269-79.

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