References for this PMC Article for PMID: 18695053

Year	Number of Results
1984	1
1996	2
1997	1
2001	1
2002	1
2003	1
2004	1
2005	1
2006	3
2007	1
2008	1
2024	0

1

Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease.

Fleisher AS, Raman R, Siemers ER, Becerra L, Clark CM, Dean RA, Farlow MR, Galvin JE, Peskind ER, Quinn JF, Sherzai A, Sowell BB, Aisen PS, Thal LJ. Fleisher AS, et al. Arch Neurol. 2008 Aug;65(8):1031-8. doi: 10.1001/archneur.65.8.1031. Arch Neurol. 2008. PMID: 18695053 Free PMC article. Clinical Trial.

2

Safety, tolerability, and effects on plasma and cerebrospinal fluid amyloid-beta after inhibition of gamma-secretase.

Siemers ER, Dean RA, Friedrich S, Ferguson-Sells L, Gonzales C, Farlow MR, May PC. Siemers ER, et al. Clin Neuropharmacol. 2007 Nov-Dec;30(6):317-25. doi: 10.1097/WNF.0b013e31805b7660. Clin Neuropharmacol. 2007. PMID: 18090456 Clinical Trial.

3

Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139.

Lanz TA, Karmilowicz MJ, Wood KM, Pozdnyakov N, Du P, Piotrowski MA, Brown TM, Nolan CE, Richter KE, Finley JE, Fei Q, Ebbinghaus CF, Chen YL, Spracklin DK, Tate B, Geoghegan KF, Lau LF, Auperin DD, Schachter JB. Lanz TA, et al. J Pharmacol Exp Ther. 2006 Nov;319(2):924-33. doi: 10.1124/jpet.106.110700. Epub 2006 Aug 18. J Pharmacol Exp Ther. 2006. PMID: 16920992

4

Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo.

Bateman RJ, Munsell LY, Morris JC, Swarm R, Yarasheski KE, Holtzman DM. Bateman RJ, et al. Nat Med. 2006 Jul;12(7):856-61. doi: 10.1038/nm1438. Epub 2006 Jun 25. Nat Med. 2006. PMID: 16799555 Free PMC article.

5

Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease.

Siemers ER, Quinn JF, Kaye J, Farlow MR, Porsteinsson A, Tariot P, Zoulnouni P, Galvin JE, Holtzman DM, Knopman DS, Satterwhite J, Gonzales C, Dean RA, May PC. Siemers ER, et al. Neurology. 2006 Feb 28;66(4):602-4. doi: 10.1212/01.WNL.0000198762.41312.E1. Neurology. 2006. PMID: 16505324 Clinical Trial.

6

Safety, tolerability, and changes in amyloid beta concentrations after administration of a gamma-secretase inhibitor in volunteers.

Siemers E, Skinner M, Dean RA, Gonzales C, Satterwhite J, Farlow M, Ness D, May PC. Siemers E, et al. Clin Neuropharmacol. 2005 May-Jun;28(3):126-32. doi: 10.1097/01.wnf.0000167360.27670.29. Clin Neuropharmacol. 2005. PMID: 15965311 Clinical Trial.

7

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation.

Wong GT, Manfra D, Poulet FM, Zhang Q, Josien H, Bara T, Engstrom L, Pinzon-Ortiz M, Fine JS, Lee HJ, Zhang L, Higgins GA, Parker EM. Wong GT, et al. J Biol Chem. 2004 Mar 26;279(13):12876-82. doi: 10.1074/jbc.M311652200. Epub 2004 Jan 6. J Biol Chem. 2004. PMID: 14709552 Free article.

8

Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.

Micchelli CA, Esler WP, Kimberly WT, Jack C, Berezovska O, Kornilova A, Hyman BT, Perrimon N, Wolfe MS. Micchelli CA, et al. FASEB J. 2003 Jan;17(1):79-81. doi: 10.1096/fj.02-0394fje. Epub 2002 Nov 1. FASEB J. 2003. PMID: 12424225

9

Implication of APP secretases in notch signaling.

Hartmann D, Tournoy J, Saftig P, Annaert W, De Strooper B. Hartmann D, et al. J Mol Neurosci. 2001 Oct;17(2):171-81. doi: 10.1385/JMN:17:2:171. J Mol Neurosci. 2001. PMID: 11816790 Review.

10

An inventory to assess activities of daily living for clinical trials in Alzheimer's disease. The Alzheimer's Disease Cooperative Study.

Galasko D, Bennett D, Sano M, Ernesto C, Thomas R, Grundman M, Ferris S. Galasko D, et al. Alzheimer Dis Assoc Disord. 1997;11 Suppl 2:S33-9. Alzheimer Dis Assoc Disord. 1997. PMID: 9236950 Clinical Trial.

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