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Results: 1 to 20 of 30

1.

Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease.

Hemming ML, Patterson M, Reske-Nielsen C, Lin L, Isacson O, Selkoe DJ.

PLoS Med. 2007 Aug;4(8):e262.

PMID:
17760499
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Production and purification of lentiviral vectors.

Tiscornia G, Singer O, Verma IM.

Nat Protoc. 2006;1(1):241-5.

PMID:
17406239
[PubMed - indexed for MEDLINE]
3.

Herpes simplex virus RNAi and neprilysin gene transfer vectors reduce accumulation of Alzheimer's disease-related amyloid-beta peptide in vivo.

Hong CS, Goins WF, Goss JR, Burton EA, Glorioso JC.

Gene Ther. 2006 Jul;13(14):1068-79. Epub 2006 Mar 16.

PMID:
16541122
[PubMed - indexed for MEDLINE]
4.

Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model.

Singer O, Marr RA, Rockenstein E, Crews L, Coufal NG, Gage FH, Verma IM, Masliah E.

Nat Neurosci. 2005 Oct;8(10):1343-9. Epub 2005 Aug 28.

PMID:
16136043
[PubMed - indexed for MEDLINE]
5.

Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease.

Maruyama M, Higuchi M, Takaki Y, Matsuba Y, Tanji H, Nemoto M, Tomita N, Matsui T, Iwata N, Mizukami H, Muramatsu S, Ozawa K, Saido TC, Arai H, Sasaki H.

Ann Neurol. 2005 Jun;57(6):832-42.

PMID:
15929037
[PubMed - indexed for MEDLINE]
6.

Decreased neprilysin immunoreactivity in Alzheimer disease, but not in pathological aging.

Wang DS, Lipton RB, Katz MJ, Davies P, Buschke H, Kuslansky G, Verghese J, Younkin SG, Eckman C, Dickson DW.

J Neuropathol Exp Neurol. 2005 May;64(5):378-85.

PMID:
15892294
[PubMed - indexed for MEDLINE]
7.

Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders.

Caccamo A, Oddo S, Sugarman MC, Akbari Y, LaFerla FM.

Neurobiol Aging. 2005 May;26(5):645-54.

PMID:
15708439
[PubMed - indexed for MEDLINE]
8.

A nontransgenic mouse model shows inducible amyloid-beta (Abeta) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade.

Dolev I, Michaelson DM.

Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13909-14. Epub 2004 Sep 13.

PMID:
15365176
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Neprilysin regulates amyloid Beta peptide levels.

Marr RA, Guan H, Rockenstein E, Kindy M, Gage FH, Verma I, Masliah E, Hersh LB.

J Mol Neurosci. 2004;22(1-2):5-11.

PMID:
14742905
[PubMed - indexed for MEDLINE]
10.

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.

Leissring MA, Farris W, Chang AY, Walsh DM, Wu X, Sun X, Frosch MP, Selkoe DJ.

Neuron. 2003 Dec 18;40(6):1087-93.

PMID:
14687544
[PubMed - indexed for MEDLINE]
11.

The neuropeptide-degrading enzyme NL1 is expressed in specific neurons of mouse brain.

Carpentier M, Marcinkiewicz M, Boileau G, DesGroseillers L.

Peptides. 2003 Jul;24(7):1083-91.

PMID:
14499288
[PubMed - indexed for MEDLINE]
12.

Ontogeny, regional and cellular distribution of the novel metalloprotease neprilysin 2 in the rat: a comparison with neprilysin and endothelin-converting enzyme-1.

Facchinetti P, Rose C, Schwartz JC, Ouimet T.

Neuroscience. 2003;118(3):627-39.

PMID:
12710972
[PubMed - indexed for MEDLINE]
13.

Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.

Marr RA, Rockenstein E, Mukherjee A, Kindy MS, Hersh LB, Gage FH, Verma IM, Masliah E.

J Neurosci. 2003 Mar 15;23(6):1992-6.

PMID:
12657655
[PubMed - indexed for MEDLINE]
Free Article
15.

Peptidases, proteases and amyloid beta-peptide catabolism.

Hersh LB.

Curr Pharm Des. 2003;9(6):449-54. Review.

PMID:
12570808
[PubMed - indexed for MEDLINE]
16.

Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging.

Iwata N, Takaki Y, Fukami S, Tsubuki S, Saido TC.

J Neurosci Res. 2002 Nov 1;70(3):493-500.

PMID:
12391610
[PubMed - indexed for MEDLINE]
17.

Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain.

Yasojima K, McGeer EG, McGeer PL.

Brain Res. 2001 Nov 16;919(1):115-21.

PMID:
11689168
[PubMed - indexed for MEDLINE]
18.

Molecular cloning, tissue distribution, and chromosomal localization of MMEL2, a gene coding for a novel human member of the neutral endopeptidase-24.11 family.

Bonvouloir N, Lemieux N, Crine P, Boileau G, DesGroseillers L.

DNA Cell Biol. 2001 Aug;20(8):493-8.

PMID:
11560781
[PubMed - indexed for MEDLINE]
19.

Immunohistochemical localization of neprilysin in the human cerebral cortex: inverse association with vulnerability to amyloid beta-protein (Abeta) deposition.

Akiyama H, Kondo H, Ikeda K, Kato M, McGeer PL.

Brain Res. 2001 Jun 1;902(2):277-81.

PMID:
11384622
[PubMed - indexed for MEDLINE]
20.

Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme.

Eckman EA, Reed DK, Eckman CB.

J Biol Chem. 2001 Jul 6;276(27):24540-8. Epub 2001 May 3.

PMID:
11337485
[PubMed - indexed for MEDLINE]
Free Article

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