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Results: 1 to 20 of 43

1.

Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites.

Pike AC, Rellos P, Niesen FH, Turnbull A, Oliver AW, Parker SA, Turk BE, Pearl LH, Knapp S.

EMBO J. 2008 Feb 20;27(4):704-14. doi: 10.1038/emboj.2008.8. Epub 2008 Jan 31.

PMID:
18239682
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo.

Ji QS, Mulvihill MJ, Rosenfeld-Franklin M, Cooke A, Feng L, Mak G, O'Connor M, Yao Y, Pirritt C, Buck E, Eyzaguirre A, Arnold LD, Gibson NW, Pachter JA.

Mol Cancer Ther. 2007 Aug;6(8):2158-67. Epub 2007 Aug 1.

PMID:
17671083
[PubMed - indexed for MEDLINE]
Free Article
3.

Autoinhibition of the insulin-like growth factor I receptor by the juxtamembrane region.

Craddock BP, Cotter C, Miller WT.

FEBS Lett. 2007 Jul 10;581(17):3235-40. Epub 2007 Jun 19.

PMID:
17586502
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R).

Velaparthi U, Wittman M, Liu P, Stoffan K, Zimmermann K, Sang X, Carboni J, Li A, Attar R, Gottardis M, Greer A, Chang CY, Jacobsen BL, Sack JS, Sun Y, Langley DR, Balasubramanian B, Vyas D.

Bioorg Med Chem Lett. 2007 Apr 15;17(8):2317-21. Epub 2007 Feb 4.

PMID:
17317169
[PubMed - indexed for MEDLINE]
5.

IGF1R signalling and its inhibition.

Riedemann J, Macaulay VM.

Endocr Relat Cancer. 2006 Dec;13 Suppl 1:S33-43. Review.

PMID:
17259557
[PubMed - indexed for MEDLINE]
Free Article
6.

Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange.

Oliver AW, Paul A, Boxall KJ, Barrie SE, Aherne GW, Garrett MD, Mittnacht S, Pearl LH.

EMBO J. 2006 Jul 12;25(13):3179-90. Epub 2006 Jun 22.

PMID:
16794575
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

The structure of Dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants.

Tokarski JS, Newitt JA, Chang CY, Cheng JD, Wittekind M, Kiefer SE, Kish K, Lee FY, Borzillerri R, Lombardo LJ, Xie D, Zhang Y, Klei HE.

Cancer Res. 2006 Jun 1;66(11):5790-7.

PMID:
16740718
[PubMed - indexed for MEDLINE]
Free Article
8.

Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity.

Wittman M, Carboni J, Attar R, Balasubramanian B, Balimane P, Brassil P, Beaulieu F, Chang C, Clarke W, Dell J, Eummer J, Frennesson D, Gottardis M, Greer A, Hansel S, Hurlburt W, Jacobson B, Krishnananthan S, Lee FY, Li A, Lin TA, Liu P, Ouellet C, Sang X, Saulnier MG, Stoffan K, Sun Y, Velaparthi U, Wong H, Yang Z, Zimmermann K, Zoeckler M, Vyas D.

J Med Chem. 2005 Sep 8;48(18):5639-43.

PMID:
16134929
[PubMed - indexed for MEDLINE]
9.

Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice.

Sakatani T, Kaneda A, Iacobuzio-Donahue CA, Carter MG, de Boom Witzel S, Okano H, Ko MS, Ohlsson R, Longo DL, Feinberg AP.

Science. 2005 Mar 25;307(5717):1976-8. Epub 2005 Feb 24.

PMID:
15731405
[PubMed - indexed for MEDLINE]
Free Article
10.

Coot: model-building tools for molecular graphics.

Emsley P, Cowtan K.

Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32. Epub 2004 Nov 26.

PMID:
15572765
[PubMed - indexed for MEDLINE]
11.

Refinement of macromolecular structures by the maximum-likelihood method.

Murshudov GN, Vagin AA, Dodson EJ.

Acta Crystallogr D Biol Crystallogr. 1997 May 1;53(Pt 3):240-55.

PMID:
15299926
[PubMed]
12.

The CCP4 suite: programs for protein crystallography.

Collaborative Computational Project, Number 4.

Acta Crystallogr D Biol Crystallogr. 1994 Sep 1;50(Pt 5):760-3.

PMID:
15299374
[PubMed]
13.

In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase.

García-Echeverría C, Pearson MA, Marti A, Meyer T, Mestan J, Zimmermann J, Gao J, Brueggen J, Capraro HG, Cozens R, Evans DB, Fabbro D, Furet P, Porta DG, Liebetanz J, Martiny-Baron G, Ruetz S, Hofmann F.

Cancer Cell. 2004 Mar;5(3):231-9.

PMID:
15050915
[PubMed - indexed for MEDLINE]
14.

Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors.

Mitsiades CS, Mitsiades NS, McMullan CJ, Poulaki V, Shringarpure R, Akiyama M, Hideshima T, Chauhan D, Joseph M, Libermann TA, García-Echeverría C, Pearson MA, Hofmann F, Anderson KC, Kung AL.

Cancer Cell. 2004 Mar;5(3):221-30.

PMID:
15050914
[PubMed - indexed for MEDLINE]
15.

Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor.

Hu J, Liu J, Ghirlando R, Saltiel AR, Hubbard SR.

Mol Cell. 2003 Dec;12(6):1379-89.

PMID:
14690593
[PubMed - indexed for MEDLINE]
16.

Structure of apo, unactivated insulin-like growth factor-1 receptor kinase at 1.5 A resolution.

Munshi S, Hall DL, Kornienko M, Darke PL, Kuo LC.

Acta Crystallogr D Biol Crystallogr. 2003 Oct;59(Pt 10):1725-30. Epub 2003 Sep 19.

PMID:
14501110
[PubMed - indexed for MEDLINE]
17.

The determination of enzyme inhibitor constants.

DIXON M.

Biochem J. 1953 Aug;55(1):170-1. No abstract available.

PMID:
13093635
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

The insulin-like growth factor system and cancer.

LeRoith D, Roberts CT Jr.

Cancer Lett. 2003 Jun 10;195(2):127-37. Review.

PMID:
12767520
[PubMed - indexed for MEDLINE]
19.

Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571).

Nagar B, Bornmann WG, Pellicena P, Schindler T, Veach DR, Miller WT, Clarkson B, Kuriyan J.

Cancer Res. 2002 Aug 1;62(15):4236-43.

PMID:
12154025
[PubMed - indexed for MEDLINE]
Free Article
20.

Crystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificity.

Munshi S, Kornienko M, Hall DL, Reid JC, Waxman L, Stirdivant SM, Darke PL, Kuo LC.

J Biol Chem. 2002 Oct 11;277(41):38797-802. Epub 2002 Jul 22.

PMID:
12138114
[PubMed - indexed for MEDLINE]
Free Article
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