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Results: 1 to 20 of 31

References for PMC Articles for PubMed (Select 18548070)

1.
2.

Conversion of the LXR-agonist TO-901317--from inverse to normal modulation of gamma-secretase by addition of a carboxylic acid and a lipophilic anchor.

Narlawar R, Baumann K, Czech C, Schmidt B.

Bioorg Med Chem Lett. 2007 Oct 1;17(19):5428-31. Epub 2007 Aug 6.

PMID:
17723298
3.

Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice.

Kukar T, Prescott S, Eriksen JL, Holloway V, Murphy MP, Koo EH, Golde TE, Nicolle MM.

BMC Neurosci. 2007 Jul 24;8:54.

4.
5.

Rapid, concurrent alterations in pre- and postsynaptic structure induced by naturally-secreted amyloid-beta protein.

Calabrese B, Shaked GM, Tabarean IV, Braga J, Koo EH, Halpain S.

Mol Cell Neurosci. 2007 Jun;35(2):183-93. Epub 2007 Feb 12.

6.

GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.

Munter LM, Voigt P, Harmeier A, Kaden D, Gottschalk KE, Weise C, Pipkorn R, Schaefer M, Langosch D, Multhaup G.

EMBO J. 2007 Mar 21;26(6):1702-12. Epub 2007 Mar 1.

7.

Scaffold of the cyclooxygenase-2 (COX-2) inhibitor carprofen provides Alzheimer gamma-secretase modulators.

Narlawar R, Pérez Revuelta BI, Haass C, Steiner H, Schmidt B, Baumann K.

J Med Chem. 2006 Dec 28;49(26):7588-91.

PMID:
17181139
9.

Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42.

Sato T, Kienlen-Campard P, Ahmed M, Liu W, Li H, Elliott JI, Aimoto S, Constantinescu SN, Octave JN, Smith SO.

Biochemistry. 2006 May 2;45(17):5503-16.

10.

Secretion of the Notch-1 Abeta-like peptide during Notch signaling.

Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.

J Biol Chem. 2006 Mar 24;281(12):7890-8. Epub 2006 Jan 23.

11.

Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42.

Leuchtenberger S, Kummer MP, Kukar T, Czirr E, Teusch N, Sagi SA, Berdeaux R, Pietrzik CU, Ladd TB, Golde TE, Koo EH, Weggen S.

J Neurochem. 2006 Jan;96(2):355-65. Epub 2005 Nov 21.

PMID:
16300630
12.

Non-steroidal anti-inflammatory drugs have anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro.

Hirohata M, Ono K, Naiki H, Yamada M.

Neuropharmacology. 2005 Dec;49(7):1088-99. Epub 2005 Aug 25.

PMID:
16125740
13.

Controlling {beta}-amyloid oligomerization by the use of naphthalene sulfonates: trapping low molecular weight oligomeric species.

Ferrão-Gonzales AD, Robbs BK, Moreau VH, Ferreira A, Juliano L, Valente AP, Almeida FC, Silva JL, Foguel D.

J Biol Chem. 2005 Oct 14;280(41):34747-54. Epub 2005 Jul 22.

14.

Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production.

Kukar T, Murphy MP, Eriksen JL, Sagi SA, Weggen S, Smith TE, Ladd T, Khan MA, Kache R, Beard J, Dodson M, Merit S, Ozols VV, Anastasiadis PZ, Das P, Fauq A, Koo EH, Golde TE.

Nat Med. 2005 May;11(5):545-50. Epub 2005 Apr 17.

PMID:
15834426
15.

Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation.

Lleó A, Berezovska O, Herl L, Raju S, Deng A, Bacskai BJ, Frosch MP, Irizarry M, Hyman BT.

Nat Med. 2004 Oct;10(10):1065-6. Epub 2004 Sep 26.

PMID:
15448688
16.

Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.

Beher D, Clarke EE, Wrigley JD, Martin AC, Nadin A, Churcher I, Shearman MS.

J Biol Chem. 2004 Oct 15;279(42):43419-26. Epub 2004 Aug 10.

17.

Purification and characterization of the human gamma-secretase complex.

Fraering PC, Ye W, Strub JM, Dolios G, LaVoie MJ, Ostaszewski BL, van Dorsselaer A, Wang R, Selkoe DJ, Wolfe MS.

Biochemistry. 2004 Aug 3;43(30):9774-89.

PMID:
15274632
18.

NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo.

Eriksen JL, Sagi SA, Smith TE, Weggen S, Das P, McLendon DC, Ozols VV, Jessing KW, Zavitz KH, Koo EH, Golde TE.

J Clin Invest. 2003 Aug;112(3):440-9.

19.

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity.

Weggen S, Eriksen JL, Sagi SA, Pietrzik CU, Ozols V, Fauq A, Golde TE, Koo EH.

J Biol Chem. 2003 Aug 22;278(34):31831-7. Epub 2003 Jun 12.

20.

Unmasking tandem site interaction in human acetylcholinesterase. Substrate activation with a cationic acetanilide substrate.

Johnson JL, Cusack B, Davies MP, Fauq A, Rosenberry TL.

Biochemistry. 2003 May 13;42(18):5438-52.

PMID:
12731886
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