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Items: 1 to 20 of 28


Defining the role of mTOR in cancer.

Guertin DA, Sabatini DM.

Cancer Cell. 2007 Jul;12(1):9-22. Review.


PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.

Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM.

Mol Cell. 2007 Mar 23;25(6):903-15.


mTOR kinase and the regulatory subunit of protein kinase A (PRKAR1A) spatially and functionally interact during autophagosome maturation.

Mavrakis M, Lippincott-Schwartz J, Stratakis CA, Bossis I.

Autophagy. 2007 Mar-Apr;3(2):151-3. Epub 2007 Mar 28.


Localization of Rheb to the endomembrane is critical for its signaling function.

Buerger C, DeVries B, Stambolic V.

Biochem Biophys Res Commun. 2006 Jun 9;344(3):869-80. Epub 2006 Apr 19.


Growing roles for the mTOR pathway.

Sarbassov DD, Ali SM, Sabatini DM.

Curr Opin Cell Biol. 2005 Dec;17(6):596-603. Epub 2005 Oct 13. Review.


Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

Nobukuni T, Joaquin M, Roccio M, Dann SG, Kim SY, Gulati P, Byfield MP, Backer JM, Natt F, Bos JL, Zwartkruis FJ, Thomas G.

Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14238-43. Epub 2005 Sep 21.


hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase.

Byfield MP, Murray JT, Backer JM.

J Biol Chem. 2005 Sep 23;280(38):33076-82. Epub 2005 Jul 27.


The TOR and EGO protein complexes orchestrate microautophagy in yeast.

Dubouloz F, Deloche O, Wanke V, Cameroni E, De Virgilio C.

Mol Cell. 2005 Jul 1;19(1):15-26.


Rheb binds and regulates the mTOR kinase.

Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J.

Curr Biol. 2005 Apr 26;15(8):702-13.


The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses.

Smith EM, Finn SG, Tee AR, Browne GJ, Proud CG.

J Biol Chem. 2005 May 13;280(19):18717-27. Epub 2005 Mar 16.


Determination of four sequential stages during microautophagy in vitro.

Kunz JB, Schwarz H, Mayer A.

J Biol Chem. 2004 Mar 12;279(11):9987-96. Epub 2003 Dec 15.


Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae.

Wedaman KP, Reinke A, Anderson S, Yates J 3rd, McCaffery JM, Powers T.

Mol Biol Cell. 2003 Mar;14(3):1204-20.


Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability.

Beugnet A, Tee AR, Taylor PM, Proud CG.

Biochem J. 2003 Jun 1;372(Pt 2):555-66. Erratum in: Biochem J. 2003 Aug 1;373(Pt 3):999.


Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.

Loewith R, Jacinto E, Wullschleger S, Lorberg A, Crespo JL, Bonenfant D, Oppliger W, Jenoe P, Hall MN.

Mol Cell. 2002 Sep;10(3):457-68.


Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.

Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, Hidayat S, Tokunaga C, Avruch J, Yonezawa K.

Cell. 2002 Jul 26;110(2):177-89.


mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.

Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM.

Cell. 2002 Jul 26;110(2):163-75.

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