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Results: 1 to 20 of 21

1.

High incidence of leukemia in large animals after stem cell gene therapy with a HOXB4-expressing retroviral vector.

Zhang XB, Beard BC, Trobridge GD, Wood BL, Sale GE, Sud R, Humphries RK, Kiem HP.

J Clin Invest. 2008 Apr;118(4):1502-10. doi: 10.1172/JCI34371.

PMID:
18357342
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Differential effects of HOXB4 on nonhuman primate short- and long-term repopulating cells.

Zhang XB, Beard BC, Beebe K, Storer B, Humphries RK, Kiem HP.

PLoS Med. 2006 May;3(5):e173. Epub 2006 May 2.

PMID:
16637742
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

Ott MG, Schmidt M, Schwarzwaelder K, Stein S, Siler U, Koehl U, Glimm H, Kühlcke K, Schilz A, Kunkel H, Naundorf S, Brinkmann A, Deichmann A, Fischer M, Ball C, Pilz I, Dunbar C, Du Y, Jenkins NA, Copeland NG, Lüthi U, Hassan M, Thrasher AJ, Hoelzer D, von Kalle C, Seger R, Grez M.

Nat Med. 2006 Apr;12(4):401-9. Epub 2006 Apr 2.

PMID:
16582916
[PubMed - indexed for MEDLINE]
4.

Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque.

Seggewiss R, Pittaluga S, Adler RL, Guenaga FJ, Ferguson C, Pilz IH, Ryu B, Sorrentino BP, Young WS 3rd, Donahue RE, von Kalle C, Nienhuis AW, Dunbar CE.

Blood. 2006 May 15;107(10):3865-7. Epub 2006 Jan 26.

PMID:
16439674
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

HOXB4 enforces equivalent fates of ES-cell-derived and adult hematopoietic cells.

Pilat S, Carotta S, Schiedlmeier B, Kamino K, Mairhofer A, Will E, Modlich U, Steinlein P, Ostertag W, Baum C, Beug H, Klump H.

Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12101-6. Epub 2005 Aug 10.

PMID:
16093308
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Overexpression of HOXB4 confers a myelo-erythroid differentiation delay in vitro.

Milsom MD, Duxbury R, Gagen D, Humphries RK, Schmidt M, von-Kalle C, Fairbairn LJ.

Leukemia. 2005 Jan;19(1):148-53. No abstract available.

PMID:
15496973
[PubMed - indexed for MEDLINE]
7.

Chance or necessity? Insertional mutagenesis in gene therapy and its consequences.

Baum C, von Kalle C, Staal FJ, Li Z, Fehse B, Schmidt M, Weerkamp F, Karlsson S, Wagemaker G, Williams DA.

Mol Ther. 2004 Jan;9(1):5-13. Review.

PMID:
14741772
[PubMed - indexed for MEDLINE]
8.

Gene therapy insertional mutagenesis insights.

Davé UP, Jenkins NA, Copeland NG.

Science. 2004 Jan 16;303(5656):333. No abstract available.

PMID:
14726584
[PubMed - indexed for MEDLINE]
Free Article
9.

Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein.

Amsellem S, Pflumio F, Bardinet D, Izac B, Charneau P, Romeo PH, Dubart-Kupperschmitt A, Fichelson S.

Nat Med. 2003 Nov;9(11):1423-7. Epub 2003 Oct 26.

PMID:
14578882
[PubMed - indexed for MEDLINE]
10.

In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein.

Krosl J, Austin P, Beslu N, Kroon E, Humphries RK, Sauvageau G.

Nat Med. 2003 Nov;9(11):1428-32. Epub 2003 Oct 26.

PMID:
14578881
[PubMed - indexed for MEDLINE]
11.

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.

Hacein-Bey-Abina S, Von Kalle C, Schmidt M, McCormack MP, Wulffraat N, Leboulch P, Lim A, Osborne CS, Pawliuk R, Morillon E, Sorensen R, Forster A, Fraser P, Cohen JI, de Saint Basile G, Alexander I, Wintergerst U, Frebourg T, Aurias A, Stoppa-Lyonnet D, Romana S, Radford-Weiss I, Gross F, Valensi F, Delabesse E, Macintyre E, Sigaux F, Soulier J, Leiva LE, Wissler M, Prinz C, Rabbitts TH, Le Deist F, Fischer A, Cavazzana-Calvo M.

Science. 2003 Oct 17;302(5644):415-9. Erratum in: Science. 2003 Oct 24;302(5645):568.

PMID:
14564000
[PubMed - indexed for MEDLINE]
Free Article
12.

Enforced adenoviral vector-mediated expression of HOXB4 in human umbilical cord blood CD34+ cells promotes myeloid differentiation but not proliferation.

Brun AC, Fan X, Björnsson JM, Humphries RK, Karlsson S.

Mol Ther. 2003 Oct;8(4):618-28.

PMID:
14529835
[PubMed - indexed for MEDLINE]
13.

A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency.

Hacein-Bey-Abina S, von Kalle C, Schmidt M, Le Deist F, Wulffraat N, McIntyre E, Radford I, Villeval JL, Fraser CC, Cavazzana-Calvo M, Fischer A.

N Engl J Med. 2003 Jan 16;348(3):255-6. No abstract available.

PMID:
12529469
[PubMed - indexed for MEDLINE]
Free Article
14.

Side effects of retroviral gene transfer into hematopoietic stem cells.

Baum C, Düllmann J, Li Z, Fehse B, Meyer J, Williams DA, von Kalle C.

Blood. 2003 Mar 15;101(6):2099-114. Epub 2003 Jan 2. Review.

PMID:
12511419
[PubMed - indexed for MEDLINE]
Free Article
15.

High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation.

Schiedlmeier B, Klump H, Will E, Arman-Kalcek G, Li Z, Wang Z, Rimek A, Friel J, Baum C, Ostertag W.

Blood. 2003 Mar 1;101(5):1759-68. Epub 2002 Oct 24.

PMID:
12406897
[PubMed - indexed for MEDLINE]
Free Article
16.

Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells.

Buske C, Feuring-Buske M, Abramovich C, Spiekermann K, Eaves CJ, Coulombel L, Sauvageau G, Hogge DE, Humphries RK.

Blood. 2002 Aug 1;100(3):862-8.

PMID:
12130496
[PubMed - indexed for MEDLINE]
Free Article
17.

Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy.

Hacein-Bey-Abina S, Le Deist F, Carlier F, Bouneaud C, Hue C, De Villartay JP, Thrasher AJ, Wulffraat N, Sorensen R, Dupuis-Girod S, Fischer A, Davies EG, Kuis W, Leiva L, Cavazzana-Calvo M.

N Engl J Med. 2002 Apr 18;346(16):1185-93.

PMID:
11961146
[PubMed - indexed for MEDLINE]
Free Article
18.

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease.

Cavazzana-Calvo M, Hacein-Bey S, de Saint Basile G, Gross F, Yvon E, Nusbaum P, Selz F, Hue C, Certain S, Casanova JL, Bousso P, Deist FL, Fischer A.

Science. 2000 Apr 28;288(5466):669-72.

PMID:
10784449
[PubMed - indexed for MEDLINE]
Free Article
19.

Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia.

Thorsteinsdottir U, Sauvageau G, Hough MR, Dragowska W, Lansdorp PM, Lawrence HJ, Largman C, Humphries RK.

Mol Cell Biol. 1997 Jan;17(1):495-505.

PMID:
8972230
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

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