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Results: 19

References for PMC Articles for PubMed (Select 18343582)


Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice.

McConlogue L, Buttini M, Anderson JP, Brigham EF, Chen KS, Freedman SB, Games D, Johnson-Wood K, Lee M, Zeller M, Liu W, Motter R, Sinha S.

J Biol Chem. 2007 Sep 7;282(36):26326-34. Epub 2007 Jul 6.


Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis.

Zhao J, Fu Y, Yasvoina M, Shao P, Hitt B, O'Connor T, Logan S, Maus E, Citron M, Berry R, Binder L, Vassar R.

J Neurosci. 2007 Apr 4;27(14):3639-49.


Bace1 modulates myelination in the central and peripheral nervous system.

Hu X, Hicks CW, He W, Wong P, Macklin WB, Trapp BD, Yan R.

Nat Neurosci. 2006 Dec;9(12):1520-5. Epub 2006 Nov 12.


BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice.

Nishitomi K, Sakaguchi G, Horikoshi Y, Gray AJ, Maeda M, Hirata-Fukae C, Becker AG, Hosono M, Sakaguchi I, Minami SS, Nakajima Y, Li HF, Takeyama C, Kihara T, Ota A, Wong PC, Aisen PS, Kato A, Kinoshita N, Matsuoka Y.

J Neurochem. 2006 Dec;99(6):1555-63. Epub 2006 Nov 2.


Control of peripheral nerve myelination by the beta-secretase BACE1.

Willem M, Garratt AN, Novak B, Citron M, Kaufmann S, Rittger A, DeStrooper B, Saftig P, Birchmeier C, Haass C.

Science. 2006 Oct 27;314(5799):664-6. Epub 2006 Sep 21.


BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

Laird FM, Cai H, Savonenko AV, Farah MH, He K, Melnikova T, Wen H, Chiang HC, Xu G, Koliatsos VE, Borchelt DR, Price DL, Lee HK, Wong PC.

J Neurosci. 2005 Dec 14;25(50):11693-709.


NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production.

Lesné S, Ali C, Gabriel C, Croci N, MacKenzie ET, Glabe CG, Plotkine M, Marchand-Verrecchia C, Vivien D, Buisson A.

J Neurosci. 2005 Oct 12;25(41):9367-77.


Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice.

Dominguez D, Tournoy J, Hartmann D, Huth T, Cryns K, Deforce S, Serneels L, Camacho IE, Marjaux E, Craessaerts K, Roebroek AJ, Schwake M, D'Hooge R, Bach P, Kalinke U, Moechars D, Alzheimer C, Reiss K, Saftig P, De Strooper B.

J Biol Chem. 2005 Sep 2;280(35):30797-806. Epub 2005 Jun 29.


Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2.

Wang P, Yang G, Mosier DR, Chang P, Zaidi T, Gong YD, Zhao NM, Dominguez B, Lee KF, Gan WB, Zheng H.

J Neurosci. 2005 Feb 2;25(5):1219-25.


BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease.

Ohno M, Sametsky EA, Younkin LH, Oakley H, Younkin SG, Citron M, Vassar R, Disterhoft JF.

Neuron. 2004 Jan 8;41(1):27-33.


APP processing and synaptic function.

Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R.

Neuron. 2003 Mar 27;37(6):925-37.


Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease.

Yang LB, Lindholm K, Yan R, Citron M, Xia W, Yang XL, Beach T, Sue L, Wong P, Price D, Li R, Shen Y.

Nat Med. 2003 Jan;9(1):3-4. No abstract available.


Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease.

Fukumoto H, Cheung BS, Hyman BT, Irizarry MC.

Arch Neurol. 2002 Sep;59(9):1381-9.


The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.

Hardy J, Selkoe DJ.

Science. 2002 Jul 19;297(5580):353-6. Review. Erratum in: Science 2002 Sep 27;297(5590):2209.


Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease.

Holsinger RM, McLean CA, Beyreuther K, Masters CL, Evin G.

Ann Neurol. 2002 Jun;51(6):783-6.


BACE1 is the major beta-secretase for generation of Abeta peptides by neurons.

Cai H, Wang Y, McCarthy D, Wen H, Borchelt DR, Price DL, Wong PC.

Nat Neurosci. 2001 Mar;4(3):233-4. No abstract available.

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