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LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration.

Shun MC, Raghavendra NK, Vandegraaff N, Daigle JE, Hughes S, Kellam P, Cherepanov P, Engelman A.

Genes Dev. 2007 Jul 15;21(14):1767-78.


HIV integration site selection: analysis by massively parallel pyrosequencing reveals association with epigenetic modifications.

Wang GP, Ciuffi A, Leipzig J, Berry CC, Bushman FD.

Genome Res. 2007 Aug;17(8):1186-94. Epub 2007 Jun 1.


Molecular mechanisms of HIV integration and therapeutic intervention.

Vandegraaff N, Engelman A.

Expert Rev Mol Med. 2007 Feb 26;9(6):1-19. Review.


HIV-1 integrase preassembled on donor DNA is refractory to activity stimulation by LEDGF/p75.

Yu F, Jones GS, Hung M, Wagner AH, MacArthur HL, Liu X, Leavitt S, McDermott MJ, Tsiang M.

Biochemistry. 2007 Mar 13;46(10):2899-908. Epub 2007 Feb 14.


An essential role for LEDGF/p75 in HIV integration.

Llano M, Saenz DT, Meehan A, Wongthida P, Peretz M, Walker WH, Teo W, Poeschla EM.

Science. 2006 Oct 20;314(5798):461-4. Epub 2006 Sep 7.


Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness.

Rahman S, Lu R, Vandegraaff N, Cherepanov P, Engelman A.

Virology. 2007 Jan 5;357(1):79-90. Epub 2006 Sep 7.


Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75.

Llano M, Vanegas M, Hutchins N, Thompson D, Delgado S, Poeschla EM.

J Mol Biol. 2006 Jul 21;360(4):760-73. Epub 2006 May 17.


Retroviral DNA integration: viral and cellular determinants of target-site selection.

Lewinski MK, Yamashita M, Emerman M, Ciuffi A, Marshall H, Crawford G, Collins F, Shinn P, Leipzig J, Hannenhalli S, Berry CC, Ecker JR, Bushman FD.

PLoS Pathog. 2006 Jun;2(6):e60. Epub 2006 Jun 23.


Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin.

Maertens GN, Cherepanov P, Engelman A.

J Cell Sci. 2006 Jun 15;119(Pt 12):2563-71. Epub 2006 May 30.


A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo.

Turlure F, Maertens G, Rahman S, Cherepanov P, Engelman A.

Nucleic Acids Res. 2006 Mar 20;34(5):1653-65. Print 2006.


A role for LEDGF/p75 in targeting HIV DNA integration.

Ciuffi A, Llano M, Poeschla E, Hoffmann C, Leipzig J, Shinn P, Ecker JR, Bushman F.

Nat Med. 2005 Dec;11(12):1287-9. Epub 2005 Nov 27.


Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

Cherepanov P, Ambrosio AL, Rahman S, Ellenberger T, Engelman A.

Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17308-13. Epub 2005 Oct 31.


Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75.

Cherepanov P, Sun ZY, Rahman S, Maertens G, Wagner G, Engelman A.

Nat Struct Mol Biol. 2005 Jun;12(6):526-32. Epub 2005 May 15.


Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication.

Emiliani S, Mousnier A, Busschots K, Maroun M, Van Maele B, Tempé D, Vandekerckhove L, Moisant F, Ben-Slama L, Witvrouw M, Christ F, Rain JC, Dargemont C, Debyser Z, Benarous R.

J Biol Chem. 2005 Jul 8;280(27):25517-23. Epub 2005 Apr 25.


Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering.

Vanegas M, Llano M, Delgado S, Thompson D, Peretz M, Poeschla E.

J Cell Sci. 2005 Apr 15;118(Pt 8):1733-43. Epub 2005 Mar 29.


Ini1/hSNF5 is dispensable for retrovirus-induced cytoplasmic accumulation of PML and does not interfere with integration.

Boese A, Sommer P, Gaussin A, Reimann A, Nehrbass U.

FEBS Lett. 2004 Dec 17;578(3):291-6.

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