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Items: 1 to 20 of 27

1.

Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.

Scuteri A, Sanna S, Chen WM, Uda M, Albai G, Strait J, Najjar S, Nagaraja R, Orrú M, Usala G, Dei M, Lai S, Maschio A, Busonero F, Mulas A, Ehret GB, Fink AA, Weder AB, Cooper RS, Galan P, Chakravarti A, Schlessinger D, Cao A, Lakatta E, Abecasis GR.

PLoS Genet. 2007 Jul;3(7):e115.

2.

Variation in FTO contributes to childhood obesity and severe adult obesity.

Dina C, Meyre D, Gallina S, Durand E, Körner A, Jacobson P, Carlsson LM, Kiess W, Vatin V, Lecoeur C, Delplanque J, Vaillant E, Pattou F, Ruiz J, Weill J, Levy-Marchal C, Horber F, Potoczna N, Hercberg S, Le Stunff C, Bougnères P, Kovacs P, Marre M, Balkau B, Cauchi S, Chèvre JC, Froguel P.

Nat Genet. 2007 Jun;39(6):724-6. Epub 2007 May 13.

PMID:
17496892
3.

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.

Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU, Prokunina-Olsson L, Ding CJ, Swift AJ, Narisu N, Hu T, Pruim R, Xiao R, Li XY, Conneely KN, Riebow NL, Sprau AG, Tong M, White PP, Hetrick KN, Barnhart MW, Bark CW, Goldstein JL, Watkins L, Xiang F, Saramies J, Buchanan TA, Watanabe RM, Valle TT, Kinnunen L, Abecasis GR, Pugh EW, Doheny KF, Bergman RN, Tuomilehto J, Collins FS, Boehnke M.

Science. 2007 Jun 1;316(5829):1341-5. Epub 2007 Apr 26.

4.

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.

Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJ, Barroso I, Wareham NJ, Karpe F, Owen KR, Cardon LR, Walker M, Hitman GA, Palmer CN, Doney AS, Morris AD, Smith GD, Hattersley AT, McCarthy MI.

Science. 2007 May 11;316(5826):889-94. Epub 2007 Apr 12.

5.

Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome.

van der Pluijm I, Garinis GA, Brandt RM, Gorgels TG, Wijnhoven SW, Diderich KE, de Wit J, Mitchell JR, van Oostrom C, Beems R, Niedernhofer LJ, Velasco S, Friedberg EC, Tanaka K, van Steeg H, Hoeijmakers JH, van der Horst GT.

PLoS Biol. 2007 Jan;5(1):e2. Erratum in: PLoS Biol. 2008 Nov;6(11):e304.

6.

Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.

Sundheim O, Vågbø CB, Bjørås M, Sousa MM, Talstad V, Aas PA, Drabløs F, Krokan HE, Tainer JA, Slupphaug G.

EMBO J. 2006 Jul 26;25(14):3389-97. Epub 2006 Jul 6.

7.

The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.

Klose RJ, Yamane K, Bae Y, Zhang D, Erdjument-Bromage H, Tempst P, Wong J, Zhang Y.

Nature. 2006 Jul 20;442(7100):312-6. Epub 2006 May 28.

PMID:
16732292
8.

Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA.

Ringvoll J, Nordstrand LM, Vågbø CB, Talstad V, Reite K, Aas PA, Lauritzen KH, Liabakk NB, Bjørk A, Doughty RW, Falnes PØ, Krokan HE, Klungland A.

EMBO J. 2006 May 17;25(10):2189-98. Epub 2006 Apr 27.

9.

Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins.

Clifton IJ, McDonough MA, Ehrismann D, Kershaw NJ, Granatino N, Schofield CJ.

J Inorg Biochem. 2006 Apr;100(4):644-69. Epub 2006 Mar 2. Review.

PMID:
16513174
10.

The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase.

Vartanian V, Lowell B, Minko IG, Wood TG, Ceci JD, George S, Ballinger SW, Corless CL, McCullough AK, Lloyd RS.

Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1864-9. Epub 2006 Jan 30.

11.

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.

Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, Cheng HL, Kennedy C, Nunez N, Bronson R, Frendewey D, Auerbach W, Valenzuela D, Karow M, Hottiger MO, Hursting S, Barrett JC, Guarente L, Mulligan R, Demple B, Yancopoulos GD, Alt FW.

Cell. 2006 Jan 27;124(2):315-29.

12.

Repair of methylation damage in DNA and RNA by mammalian AlkB homologues.

Lee DH, Jin SG, Cai S, Chen Y, Pfeifer GP, O'Connor TR.

J Biol Chem. 2005 Nov 25;280(47):39448-59. Epub 2005 Sep 20.

13.

Monogenic obesity in humans.

Farooqi IS, O'Rahilly S.

Annu Rev Med. 2005;56:443-58. Review.

PMID:
15660521
14.

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase.

Selak MA, Armour SM, MacKenzie ED, Boulahbel H, Watson DG, Mansfield KD, Pan Y, Simon MC, Thompson CB, Gottlieb E.

Cancer Cell. 2005 Jan;7(1):77-85.

15.

AlkB restores the biological function of mRNA and tRNA inactivated by chemical methylation.

Ougland R, Zhang CM, Liiv A, Johansen RF, Seeberg E, Hou YM, Remme J, Falnes PØ.

Mol Cell. 2004 Oct 8;16(1):107-16.

16.
17.

Demethylation of 3-methylthymine in DNA by bacterial and human DNA dioxygenases.

Koivisto P, Robins P, Lindahl T, Sedgwick B.

J Biol Chem. 2004 Sep 24;279(39):40470-4. Epub 2004 Jul 20.

18.

FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymes.

Hausinger RP.

Crit Rev Biochem Mol Biol. 2004 Jan-Feb;39(1):21-68. Review.

PMID:
15121720
19.

Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.

Aas PA, Otterlei M, Falnes PO, Vågbø CB, Skorpen F, Akbari M, Sundheim O, Bjørås M, Slupphaug G, Seeberg E, Krokan HE.

Nature. 2003 Feb 20;421(6925):859-63.

PMID:
12594517
20.

Reversal of DNA alkylation damage by two human dioxygenases.

Duncan T, Trewick SC, Koivisto P, Bates PA, Lindahl T, Sedgwick B.

Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16660-5. Epub 2002 Dec 16.

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