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Items: 1 to 20 of 24

1.

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease.

Ito G, Okai T, Fujino G, Takeda K, Ichijo H, Katada T, Iwatsubo T.

Biochemistry. 2007 Feb 6;46(5):1380-8.

PMID:
17260967
2.

A Rac-cGMP signaling pathway.

Guo D, Tan YC, Wang D, Madhusoodanan KS, Zheng Y, Maack T, Zhang JJ, Huang XY.

Cell. 2007 Jan 26;128(2):341-55.

3.

Localization of LRRK2 to membranous and vesicular structures in mammalian brain.

Biskup S, Moore DJ, Celsi F, Higashi S, West AB, Andrabi SA, Kurkinen K, Yu SW, Savitt JM, Waldvogel HJ, Faull RL, Emson PC, Torp R, Ottersen OP, Dawson TM, Dawson VL.

Ann Neurol. 2006 Nov;60(5):557-69.

PMID:
17120249
4.

The familial Parkinsonism gene LRRK2 regulates neurite process morphology.

MacLeod D, Dowman J, Hammond R, Leete T, Inoue K, Abeliovich A.

Neuron. 2006 Nov 22;52(4):587-93.

5.

Kinase activity of mutant LRRK2 mediates neuronal toxicity.

Smith WW, Pei Z, Jiang H, Dawson VL, Dawson TM, Ross CA.

Nat Neurosci. 2006 Oct;9(10):1231-3. Epub 2006 Sep 17.

PMID:
16980962
6.

Distribution of PINK1 and LRRK2 in rat and mouse brain.

Taymans JM, Van den Haute C, Baekelandt V.

J Neurochem. 2006 Aug;98(3):951-61. Epub 2006 Jun 12.

7.

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin.

Greggio E, Jain S, Kingsbury A, Bandopadhyay R, Lewis P, Kaganovich A, van der Brug MP, Beilina A, Blackinton J, Thomas KJ, Ahmad R, Miller DW, Kesavapany S, Singleton A, Lees A, Harvey RJ, Harvey K, Cookson MR.

Neurobiol Dis. 2006 Aug;23(2):329-41. Epub 2006 Jun 5.

PMID:
16750377
8.

LRRK2 in Parkinson's disease: protein domains and functional insights.

Mata IF, Wedemeyer WJ, Farrer MJ, Taylor JP, Gallo KA.

Trends Neurosci. 2006 May;29(5):286-93. Epub 2006 Apr 17. Review.

PMID:
16616379
9.

LRRK2 expression linked to dopamine-innervated areas.

Galter D, Westerlund M, Carmine A, Lindqvist E, Sydow O, Olson L.

Ann Neurol. 2006 Apr;59(4):714-9.

PMID:
16532471
10.

Anatomical localization of leucine-rich repeat kinase 2 in mouse brain.

Melrose H, Lincoln S, Tyndall G, Dickson D, Farrer M.

Neuroscience. 2006;139(3):791-4. Epub 2006 Feb 28.

PMID:
16504409
11.

Biochemical and pathological characterization of Lrrk2.

Giasson BI, Covy JP, Bonini NM, Hurtig HI, Farrer MJ, Trojanowski JQ, Van Deerlin VM.

Ann Neurol. 2006 Feb;59(2):315-22.

PMID:
16437584
12.

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity.

Gloeckner CJ, Kinkl N, Schumacher A, Braun RJ, O'Neill E, Meitinger T, Kolch W, Prokisch H, Ueffing M.

Hum Mol Genet. 2006 Jan 15;15(2):223-32. Epub 2005 Dec 1.

13.

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity.

West AB, Moore DJ, Biskup S, Bugayenko A, Smith WW, Ross CA, Dawson VL, Dawson TM.

Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16842-7. Epub 2005 Nov 3.

14.

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology.

Zimprich A, Biskup S, Leitner P, Lichtner P, Farrer M, Lincoln S, Kachergus J, Hulihan M, Uitti RJ, Calne DB, Stoessl AJ, Pfeiffer RF, Patenge N, Carbajal IC, Vieregge P, Asmus F, Müller-Myhsok B, Dickson DW, Meitinger T, Strom TM, Wszolek ZK, Gasser T.

Neuron. 2004 Nov 18;44(4):601-7.

15.

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease.

Paisán-Ruíz C, Jain S, Evans EW, Gilks WP, Simón J, van der Brug M, López de Munain A, Aparicio S, Gil AM, Khan N, Johnson J, Martinez JR, Nicholl D, Carrera IM, Pena AS, de Silva R, Lees A, Martí-Massó JF, Pérez-Tur J, Wood NW, Singleton AB.

Neuron. 2004 Nov 18;44(4):595-600.

16.

Roc, a Ras/GTPase domain in complex proteins.

Bosgraaf L, Van Haastert PJ.

Biochim Biophys Acta. 2003 Dec 7;1643(1-3):5-10. Review.

17.

GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.

Xia C, Ma W, Stafford LJ, Liu C, Gong L, Martin JF, Liu M.

Mol Cell Biol. 2003 Apr;23(7):2476-88.

18.

BAC to the future: the use of bac transgenic mice for neuroscience research.

Heintz N.

Nat Rev Neurosci. 2001 Dec;2(12):861-70. Review. No abstract available.

PMID:
11733793
19.

Failure of the ubiquitin-proteasome system in Parkinson's disease.

McNaught KS, Olanow CW, Halliwell B, Isacson O, Jenner P.

Nat Rev Neurosci. 2001 Aug;2(8):589-94. Review. No abstract available.

PMID:
11484002
20.

The Rab GTPase family.

Stenmark H, Olkkonen VM.

Genome Biol. 2001;2(5):REVIEWS3007. Epub 2001 Apr 27. Review.

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