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HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity.

Gordan JD, Bertout JA, Hu CJ, Diehl JA, Simon MC.

Cancer Cell. 2007 Apr;11(4):335-47.


PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR.

Bernardi R, Guernah I, Jin D, Grisendi S, Alimonti A, Teruya-Feldstein J, Cordon-Cardo C, Simon MC, Rafii S, Pandolfi PP.

Nature. 2006 Aug 17;442(7104):779-85.


E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis.

Jung CR, Hwang KS, Yoo J, Cho WK, Kim JM, Kim WH, Im DS.

Nat Med. 2006 Jul;12(7):809-16. Epub 2006 Jul 2.


Lysyl oxidase is essential for hypoxia-induced metastasis.

Erler JT, Bennewith KL, Nicolau M, Dornhöfer N, Kong C, Le QT, Chi JT, Jeffrey SS, Giaccia AJ.

Nature. 2006 Apr 27;440(7088):1222-6.


Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells.

Hu CJ, Iyer S, Sataur A, Covello KL, Chodosh LA, Simon MC.

Mol Cell Biol. 2006 May;26(9):3514-26.


Multiple functions of Notch signaling in self-renewing organs and cancer.

Wilson A, Radtke F.

FEBS Lett. 2006 May 22;580(12):2860-8. Epub 2006 Mar 20. Review.


HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption.

Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC.

Cell Metab. 2006 Mar;3(3):187-97.


HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.

Covello KL, Kehler J, Yu H, Gordan JD, Arsham AM, Hu CJ, Labosky PA, Simon MC, Keith B.

Genes Dev. 2006 Mar 1;20(5):557-70.


Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers.

Chi JT, Wang Z, Nuyten DS, Rodriguez EH, Schaner ME, Salim A, Wang Y, Kristensen GB, Helland A, Børresen-Dale AL, Giaccia A, Longaker MT, Hastie T, Yang GP, van de Vijver MJ, Brown PO.

PLoS Med. 2006 Mar;3(3):e47.


Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer.

Thomas GV, Tran C, Mellinghoff IK, Welsbie DS, Chan E, Fueger B, Czernin J, Sawyers CL.

Nat Med. 2006 Jan;12(1):122-7. Epub 2005 Dec 11.


Angiogenic inhibitors: a new therapeutic strategy in oncology.

Gasparini G, Longo R, Toi M, Ferrara N.

Nat Clin Pract Oncol. 2005 Nov;2(11):562-77. Review.


Hypoxia requires notch signaling to maintain the undifferentiated cell state.

Gustafsson MV, Zheng X, Pereira T, Gradin K, Jin S, Lundkvist J, Ruas JL, Poellinger L, Lendahl U, Bondesson M.

Dev Cell. 2005 Nov;9(5):617-28.


Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity.

Kong D, Park EJ, Stephen AG, Calvani M, Cardellina JH, Monks A, Fisher RJ, Shoemaker RH, Melillo G.

Cancer Res. 2005 Oct 1;65(19):9047-55.


Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer.

Lee S, Nakamura E, Yang H, Wei W, Linggi MS, Sajan MP, Farese RV, Freeman RS, Carter BD, Kaelin WG Jr, Schlisio S.

Cancer Cell. 2005 Aug;8(2):155-67.


HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability.

Isaacs JS, Jung YJ, Mole DR, Lee S, Torres-Cabala C, Chung YL, Merino M, Trepel J, Zbar B, Toro J, Ratcliffe PJ, Linehan WM, Neckers L.

Cancer Cell. 2005 Aug;8(2):143-53.


Genetic evidence for a tumor suppressor role of HIF-2alpha.

Acker T, Diez-Juan A, Aragones J, Tjwa M, Brusselmans K, Moons L, Fukumura D, Moreno-Murciano MP, Herbert JM, Burger A, Riedel J, Elvert G, Flamme I, Maxwell PH, Collen D, Dewerchin M, Jain RK, Plate KH, Carmeliet P.

Cancer Cell. 2005 Aug;8(2):131-41.


Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity.

Moeller BJ, Dreher MR, Rabbani ZN, Schroeder T, Cao Y, Li CY, Dewhirst MW.

Cancer Cell. 2005 Aug;8(2):99-110.


Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation.

Brunelle JK, Bell EL, Quesada NM, Vercauteren K, Tiranti V, Zeviani M, Scarpulla RC, Chandel NS.

Cell Metab. 2005 Jun;1(6):409-14.


Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing.

Guzy RD, Hoyos B, Robin E, Chen H, Liu L, Mansfield KD, Simon MC, Hammerling U, Schumacker PT.

Cell Metab. 2005 Jun;1(6):401-8.

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