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Results: 1 to 20 of 35

1.

Flavopiridol (L86 8275; NSC 649890), a new kinase inhibitor for tumor therapy.

Sedlacek H, Czech J, Naik R, Kaur G, Worland P, Losiewicz M, Parker B, Carlson B, Smith A, Senderowicz A, Sausville E.

Int J Oncol. 1996 Dec;9(6):1143-68.

PMID:
21541623
[PubMed]
2.

Synthesis and anti-tubulin activity of a 3'-(4-azidophenyl)-3'-dephenylpaclitaxel photoaffinity probe.

Spletstoser JT, Flaherty PT, Himes RH, Georg GI.

J Med Chem. 2004 Dec 16;47(26):6459-65.

PMID:
15588080
[PubMed - indexed for MEDLINE]
3.

Toward a pharmacophore for kinase frequent hitters.

Aronov AM, Murcko MA.

J Med Chem. 2004 Nov 4;47(23):5616-9.

PMID:
15509160
[PubMed - indexed for MEDLINE]
4.

A new alkaloid from Dysoxylum binectariferum.

Yang DH, Cai SQ, Zhao YY, Liang H.

J Asian Nat Prod Res. 2004 Sep;6(3):233-6.

PMID:
15224423
[PubMed - indexed for MEDLINE]
5.

Protein kinase inhibitors: insights into drug design from structure.

Noble ME, Endicott JA, Johnson LN.

Science. 2004 Mar 19;303(5665):1800-5. Review.

PMID:
15031492
[PubMed - indexed for MEDLINE]
6.

Versatile fluorescence probes of protein kinase activity.

Shults MD, Imperiali B.

J Am Chem Soc. 2003 Nov 26;125(47):14248-9.

PMID:
14624552
[PubMed - indexed for MEDLINE]
7.

Novel small molecule cyclin-dependent kinases modulators in human clinical trials.

Senderowicz AM.

Cancer Biol Ther. 2003 Jul-Aug;2(4 Suppl 1):S84-95. Review.

PMID:
14508085
[PubMed - indexed for MEDLINE]
Free Article
8.

Cyclin-dependent kinase modulators studied at the NCI: pre-clinical and clinical studies.

Sausville EA.

Curr Med Chem Anticancer Agents. 2003 Jan;3(1):47-56. Review.

PMID:
12678914
[PubMed - indexed for MEDLINE]
9.

Kinase inhibitors: not just for kinases anymore.

McGovern SL, Shoichet BK.

J Med Chem. 2003 Apr 10;46(8):1478-83.

PMID:
12672248
[PubMed - indexed for MEDLINE]
10.

Issues and progress with protein kinase inhibitors for cancer treatment.

Dancey J, Sausville EA.

Nat Rev Drug Discov. 2003 Apr;2(4):296-313. Review.

PMID:
12669029
[PubMed - indexed for MEDLINE]
11.

Progress toward the development of agents to modulate the cell cycle.

Toogood PL.

Curr Opin Chem Biol. 2002 Aug;6(4):472-8. Review.

PMID:
12133723
[PubMed - indexed for MEDLINE]
12.

Protein kinases--the major drug targets of the twenty-first century?

Cohen P.

Nat Rev Drug Discov. 2002 Apr;1(4):309-15. Review.

PMID:
12120282
[PubMed - indexed for MEDLINE]
13.

Structure-based design and synthesis of 2-benzylidene-benzofuran-3-ones as flavopiridol mimics.

Schoepfer J, Fretz H, Chaudhuri B, Muller L, Seeber E, Meijer L, Lozach O, Vangrevelinghe E, Furet P.

J Med Chem. 2002 Apr 25;45(9):1741-7.

PMID:
11960485
[PubMed - indexed for MEDLINE]
14.

Cyclin-dependent kinases.

Harper JW, Adams PD.

Chem Rev. 2001 Aug;101(8):2511-26. Review. No abstract available.

PMID:
11749386
[PubMed - indexed for MEDLINE]
15.

Protein kinases as therapeutic targets.

Sridhar R, Hanson-Painton O, Cooper DR.

Pharm Res. 2000 Nov;17(11):1345-53. Review.

PMID:
11205726
[PubMed - indexed for MEDLINE]
16.

Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: current status.

Kelland LR.

Expert Opin Investig Drugs. 2000 Dec;9(12):2903-11. Review.

PMID:
11093360
[PubMed - indexed for MEDLINE]
17.

Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects.

Kim KS, Sack JS, Tokarski JS, Qian L, Chao ST, Leith L, Kelly YF, Misra RN, Hunt JT, Kimball SD, Humphreys WG, Wautlet BS, Mulheron JG, Webster KR.

J Med Chem. 2000 Nov 2;43(22):4126-34.

PMID:
11063609
[PubMed - indexed for MEDLINE]
18.

The therapeutic potential of flavonoids.

Wang HK.

Expert Opin Investig Drugs. 2000 Sep;9(9):2103-19. Review.

PMID:
11060796
[PubMed - indexed for MEDLINE]
19.

Cyclin-dependent kinase inhibitors: novel anticancer agents.

Mani S, Wang C, Wu K, Francis R, Pestell R.

Expert Opin Investig Drugs. 2000 Aug;9(8):1849-70. Review.

PMID:
11060782
[PubMed - indexed for MEDLINE]
20.

Inhibitors of cyclin-dependent kinases as anti-cancer therapeutics.

Fischer PM, Lane DP.

Curr Med Chem. 2000 Dec;7(12):1213-45.

PMID:
11032968
[PubMed - indexed for MEDLINE]

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