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Items: 1 to 20 of 59

1.

In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules.

Yan J, Parekh VV, Mendez-Fernandez Y, Olivares-Villagómez D, Dragovic S, Hill T, Roopenian DC, Joyce S, Van Kaer L.

J Exp Med. 2006 Mar 20;203(3):647-59. Epub 2006 Feb 27.

2.

The aminopeptidase ERAAP shapes the peptide repertoire displayed by major histocompatibility complex class I molecules.

Hammer GE, Gonzalez F, Champsaur M, Cado D, Shastri N.

Nat Immunol. 2006 Jan;7(1):103-12. Epub 2005 Nov 20.

PMID:
16299505
3.

The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a "molecular ruler" mechanism.

Chang SC, Momburg F, Bhutani N, Goldberg AL.

Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17107-12. Epub 2005 Nov 14.

4.

Leucine aminopeptidase is not essential for trimming peptides in the cytosol or generating epitopes for MHC class I antigen presentation.

Towne CF, York IA, Neijssen J, Karow ML, Murphy AJ, Valenzuela DM, Yancopoulos GD, Neefjes JJ, Rock KL.

J Immunol. 2005 Nov 15;175(10):6605-14.

5.

Immunoproteasome-deficient mice mount largely normal CD8+ T cell responses to lymphocytic choriomeningitis virus infection and DNA vaccination.

Nussbaum AK, Rodriguez-Carreno MP, Benning N, Botten J, Whitton JL.

J Immunol. 2005 Jul 15;175(2):1153-60.

6.
7.

Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines.

Tscharke DC, Karupiah G, Zhou J, Palmore T, Irvine KR, Haeryfar SM, Williams S, Sidney J, Sette A, Bennink JR, Yewdell JW.

J Exp Med. 2005 Jan 3;201(1):95-104. Epub 2004 Dec 28.

8.

Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus.

Basler M, Youhnovski N, Van Den Broek M, Przybylski M, Groettrup M.

J Immunol. 2004 Sep 15;173(6):3925-34.

9.

Pathway for degradation of peptides generated by proteasomes: a key role for thimet oligopeptidase and other metallopeptidases.

Saric T, Graef CI, Goldberg AL.

J Biol Chem. 2004 Nov 5;279(45):46723-32. Epub 2004 Aug 24.

10.
12.

A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation.

Reits E, Neijssen J, Herberts C, Benckhuijsen W, Janssen L, Drijfhout JW, Neefjes J.

Immunity. 2004 Apr;20(4):495-506.

13.

Cellular protein is the source of cross-priming antigen in vivo.

Shen L, Rock KL.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3035-40. Epub 2004 Feb 20.

14.

CD4 T cell-dependent CD8 T cell maturation.

Khanolkar A, Fuller MJ, Zajac AJ.

J Immunol. 2004 Mar 1;172(5):2834-44.

15.

Immunodominance of an antiviral cytotoxic T cell response is shaped by the kinetics of viral protein expression.

Probst HC, Tschannen K, Gallimore A, Martinic M, Basler M, Dumrese T, Jones E, van den Broek MF.

J Immunol. 2003 Nov 15;171(10):5415-22.

16.
17.

Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment.

Wherry EJ, Blattman JN, Murali-Krishna K, van der Most R, Ahmed R.

J Virol. 2003 Apr;77(8):4911-27.

18.

The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation.

York IA, Mo AX, Lemerise K, Zeng W, Shen Y, Abraham CR, Saric T, Goldberg AL, Rock KL.

Immunity. 2003 Mar;18(3):429-40.

19.

The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues.

York IA, Chang SC, Saric T, Keys JA, Favreau JM, Goldberg AL, Rock KL.

Nat Immunol. 2002 Dec;3(12):1177-84. Epub 2002 Nov 18.

PMID:
12436110
20.

An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides.

Saric T, Chang SC, Hattori A, York IA, Markant S, Rock KL, Tsujimoto M, Goldberg AL.

Nat Immunol. 2002 Dec;3(12):1169-76. Epub 2002 Nov 18.

PMID:
12436109
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