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Results: 1 to 20 of 33

1.

Valosin-containing protein phosphorylation at Ser784 in response to DNA damage.

Livingstone M, Ruan H, Weiner J, Clauser KR, Strack P, Jin S, Williams A, Greulich H, Gardner J, Venere M, Mochan TA, DiTullio RA Jr, Moravcevic K, Gorgoulis VG, Burkhardt A, Halazonetis TD.

Cancer Res. 2005 Sep 1;65(17):7533-40.

PMID:
16140914
[PubMed - indexed for MEDLINE]
Free Article
2.

Constitutively activated FGFR3 mutants signal through PLCgamma-dependent and -independent pathways for hematopoietic transformation.

Chen J, Williams IR, Lee BH, Duclos N, Huntly BJ, Donoghue DJ, Gilliland DG.

Blood. 2005 Jul 1;106(1):328-37. Epub 2005 Mar 22.

PMID:
15784730
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations.

Choudhary C, Schwäble J, Brandts C, Tickenbrock L, Sargin B, Kindler T, Fischer T, Berdel WE, Müller-Tidow C, Serve H.

Blood. 2005 Jul 1;106(1):265-73. Epub 2005 Mar 15.

PMID:
15769897
[PubMed - indexed for MEDLINE]
Free Article
4.

FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model.

Grundler R, Miething C, Thiede C, Peschel C, Duyster J.

Blood. 2005 Jun 15;105(12):4792-9. Epub 2005 Feb 17.

PMID:
15718420
[PubMed - indexed for MEDLINE]
Free Article
5.

Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival.

Kim KT, Baird K, Ahn JY, Meltzer P, Lilly M, Levis M, Small D.

Blood. 2005 Feb 15;105(4):1759-67. Epub 2004 Oct 21.

PMID:
15498859
[PubMed - indexed for MEDLINE]
Free Article
6.

A juxtamembrane tyrosine in the colony stimulating factor-1 receptor regulates ligand-induced Src association, receptor kinase function, and down-regulation.

Rohde CM, Schrum J, Lee AW.

J Biol Chem. 2004 Oct 15;279(42):43448-61. Epub 2004 Aug 5.

PMID:
15297464
[PubMed - indexed for MEDLINE]
Free Article
7.

Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages.

Kimura Y, Jones N, Klüppel M, Hirashima M, Tachibana K, Cohn JB, Wrana JL, Pawson T, Bernstein A.

Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6015-20. Epub 2004 Apr 5.

PMID:
15067126
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

The structural basis for autoinhibition of FLT3 by the juxtamembrane domain.

Griffith J, Black J, Faerman C, Swenson L, Wynn M, Lu F, Lippke J, Saxena K.

Mol Cell. 2004 Jan 30;13(2):169-78.

PMID:
14759363
[PubMed - indexed for MEDLINE]
9.

Different antiapoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia.

Minami Y, Yamamoto K, Kiyoi H, Ueda R, Saito H, Naoe T.

Blood. 2003 Oct 15;102(8):2969-75. Epub 2003 Jul 3.

PMID:
12842996
[PubMed - indexed for MEDLINE]
Free Article
10.

Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3).

Murata K, Kumagai H, Kawashima T, Tamitsu K, Irie M, Nakajima H, Suzu S, Shibuya M, Kamihira S, Nosaka T, Asano S, Kitamura T.

J Biol Chem. 2003 Aug 29;278(35):32892-8. Epub 2003 Jun 18.

PMID:
12815052
[PubMed - indexed for MEDLINE]
Free Article
11.

Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells.

Spiekermann K, Bagrintseva K, Schwab R, Schmieja K, Hiddemann W.

Clin Cancer Res. 2003 Jun;9(6):2140-50.

PMID:
12796379
[PubMed - indexed for MEDLINE]
Free Article
12.

The roles of FLT3 in hematopoiesis and leukemia.

Gilliland DG, Griffin JD.

Blood. 2002 Sep 1;100(5):1532-42. Review.

PMID:
12176867
[PubMed - indexed for MEDLINE]
Free Article
13.

Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain.

Kiyoi H, Ohno R, Ueda R, Saito H, Naoe T.

Oncogene. 2002 Apr 11;21(16):2555-63.

PMID:
11971190
[PubMed - indexed for MEDLINE]
Free Article
14.

FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model.

Kelly LM, Liu Q, Kutok JL, Williams IR, Boulton CL, Gilliland DG.

Blood. 2002 Jan 1;99(1):310-8.

PMID:
11756186
[PubMed - indexed for MEDLINE]
Free Article
15.

The TEL/PDGFbetaR fusion in chronic myelomonocytic leukemia signals through STAT5-dependent and STAT5-independent pathways.

Sternberg DW, Tomasson MH, Carroll M, Curley DP, Barker G, Caprio M, Wilbanks A, Kazlauskas A, Gilliland DG.

Blood. 2001 Dec 1;98(12):3390-7.

PMID:
11719379
[PubMed - indexed for MEDLINE]
Free Article
16.

Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways.

Mizuki M, Fenski R, Halfter H, Matsumura I, Schmidt R, Müller C, Grüning W, Kratz-Albers K, Serve S, Steur C, Büchner T, Kienast J, Kanakura Y, Berdel WE, Serve H.

Blood. 2000 Dec 1;96(12):3907-14.

PMID:
11090077
[PubMed - indexed for MEDLINE]
Free Article
17.

Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase.

Zhang S, Broxmeyer HE.

Biochem Biophys Res Commun. 2000 Oct 14;277(1):195-9.

PMID:
11027663
[PubMed - indexed for MEDLINE]
18.

Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling.

Zhang S, Fukuda S, Lee Y, Hangoc G, Cooper S, Spolski R, Leonard WJ, Broxmeyer HE.

J Exp Med. 2000 Sep 4;192(5):719-28.

PMID:
10974037
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells.

McKenna HJ, Stocking KL, Miller RE, Brasel K, De Smedt T, Maraskovsky E, Maliszewski CR, Lynch DH, Smith J, Pulendran B, Roux ER, Teepe M, Lyman SD, Peschon JJ.

Blood. 2000 Jun 1;95(11):3489-97.

PMID:
10828034
[PubMed - indexed for MEDLINE]
Free Article
20.

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines.

Hayakawa F, Towatari M, Kiyoi H, Tanimoto M, Kitamura T, Saito H, Naoe T.

Oncogene. 2000 Feb 3;19(5):624-31.

PMID:
10698507
[PubMed - indexed for MEDLINE]
Free Article

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