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Results: 1 to 20 of 69

1.

PKC 412 FLT3 inhibitor therapy in AML: results of a phase II trial.

Stone RM, De Angelo J, Galinsky I, Estey E, Klimek V, Grandin W, Lebwohl D, Yap A, Cohen P, Fox E, Neuberg D, Clark J, Gilliland DG, Griffin JD.

Ann Hematol. 2004;83 Suppl 1:S89-90. No abstract available.

PMID:
15124689
[PubMed - indexed for MEDLINE]
2.

FLT3 inhibitors: a paradigm for the development of targeted therapeutics for paediatric cancer.

Brown P, Small D.

Eur J Cancer. 2004 Mar;40(5):707-21, discussion 722-4. Review.

PMID:
15010072
[PubMed - indexed for MEDLINE]
3.

CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations.

Fröhling S, Schlenk RF, Stolze I, Bihlmayr J, Benner A, Kreitmeier S, Tobis K, Döhner H, Döhner K.

J Clin Oncol. 2004 Feb 15;22(4):624-33. Epub 2004 Jan 15.

PMID:
14726504
[PubMed - indexed for MEDLINE]
Free Article
4.

Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia.

Smith BD, Levis M, Beran M, Giles F, Kantarjian H, Berg K, Murphy KM, Dauses T, Allebach J, Small D.

Blood. 2004 May 15;103(10):3669-76. Epub 2004 Jan 15.

PMID:
14726387
[PubMed - indexed for MEDLINE]
Free Article
5.

Phosphorylation of C/EBPalpha inhibits granulopoiesis.

Ross SE, Radomska HS, Wu B, Zhang P, Winnay JN, Bajnok L, Wright WS, Schaufele F, Tenen DG, MacDougald OA.

Mol Cell Biol. 2004 Jan;24(2):675-86.

PMID:
14701740
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

A dominant-negative mutant of C/EBPalpha, associated with acute myeloid leukemias, inhibits differentiation of myeloid and erythroid progenitors of man but not mouse.

Schwieger M, Löhler J, Fischer M, Herwig U, Tenen DG, Stocking C.

Blood. 2004 Apr 1;103(7):2744-52. Epub 2003 Dec 4.

PMID:
14656889
[PubMed - indexed for MEDLINE]
Free Article
7.

An innovative phase I clinical study demonstrates inhibition of FLT3 phosphorylation by SU11248 in acute myeloid leukemia patients.

O'Farrell AM, Foran JM, Fiedler W, Serve H, Paquette RL, Cooper MA, Yuen HA, Louie SG, Kim H, Nicholas S, Heinrich MC, Berdel WE, Bello C, Jacobs M, Scigalla P, Manning WC, Kelsey S, Cherrington JM.

Clin Cancer Res. 2003 Nov 15;9(15):5465-76.

PMID:
14654525
[PubMed - indexed for MEDLINE]
Free Article
8.

CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK).

Allen LF, Sebolt-Leopold J, Meyer MB.

Semin Oncol. 2003 Oct;30(5 Suppl 16):105-16. Review.

PMID:
14613031
[PubMed - indexed for MEDLINE]
9.

Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPalpha expression.

Zheng R, Friedman AD, Levis M, Li L, Weir EG, Small D.

Blood. 2004 Mar 1;103(5):1883-90. Epub 2003 Oct 30.

PMID:
14592841
[PubMed - indexed for MEDLINE]
Free Article
10.

Downmodulation of ERK activity inhibits the proliferation and induces the apoptosis of primary acute myelogenous leukemia blasts.

Lunghi P, Tabilio A, Dall'Aglio PP, Ridolo E, Carlo-Stella C, Pelicci PG, Bonati A.

Leukemia. 2003 Sep;17(9):1783-93.

PMID:
12970778
[PubMed - indexed for MEDLINE]
11.

The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells.

D'Alo' F, Johansen LM, Nelson EA, Radomska HS, Evans EK, Zhang P, Nerlov C, Tenen DG.

Blood. 2003 Nov 1;102(9):3163-71. Epub 2003 Jul 17.

PMID:
12869508
[PubMed - indexed for MEDLINE]
Free Article
12.

A phase 2 clinical study of SU5416 in patients with refractory acute myeloid leukemia.

Fiedler W, Mesters R, Tinnefeld H, Loges S, Staib P, Duhrsen U, Flasshove M, Ottmann OG, Jung W, Cavalli F, Kuse R, Thomalla J, Serve H, O'Farrell AM, Jacobs M, Brega NM, Scigalla P, Hossfeld DK, Berdel WE.

Blood. 2003 Oct 15;102(8):2763-7. Epub 2003 Jul 3.

PMID:
12843001
[PubMed - indexed for MEDLINE]
Free Article
13.

Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.

Chang F, Steelman LS, Lee JT, Shelton JG, Navolanic PM, Blalock WL, Franklin RA, McCubrey JA.

Leukemia. 2003 Jul;17(7):1263-93. Review.

PMID:
12835716
[PubMed - indexed for MEDLINE]
14.

Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells.

Spiekermann K, Bagrintseva K, Schwab R, Schmieja K, Hiddemann W.

Clin Cancer Res. 2003 Jun;9(6):2140-50.

PMID:
12796379
[PubMed - indexed for MEDLINE]
Free Article
15.

Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML.

Barjesteh van Waalwijk van Doorn-Khosrovani S, Erpelinck C, Meijer J, van Oosterhoud S, van Putten WL, Valk PJ, Berna Beverloo H, Tenen DG, Löwenberg B, Delwel R.

Hematol J. 2003;4(1):31-40.

PMID:
12692518
[PubMed - indexed for MEDLINE]
16.

Mutations of CEBPA in acute myeloid leukemia FAB types M1 and M2.

Snaddon J, Smith ML, Neat M, Cambal-Parrales M, Dixon-McIver A, Arch R, Amess JA, Rohatiner AZ, Lister TA, Fitzgibbon J.

Genes Chromosomes Cancer. 2003 May;37(1):72-8.

PMID:
12661007
[PubMed - indexed for MEDLINE]
17.

Map kinase signaling pathways and hematologic malignancies.

Platanias LC.

Blood. 2003 Jun 15;101(12):4667-79. Epub 2003 Mar 6. Review.

PMID:
12623839
[PubMed - indexed for MEDLINE]
Free Article
18.

The emergence of a C/EBPalpha mutation in the clonal evolution of MDS towards secondary AML.

Kaeferstein A, Krug U, Tiesmeier J, Aivado M, Faulhaber M, Stadler M, Krauter J, Germing U, Hofmann WK, Koeffler HP, Ganser A, Verbeek W.

Leukemia. 2003 Feb;17(2):343-9.

PMID:
12592334
[PubMed - indexed for MEDLINE]
19.

Disruption of differentiation in human cancer: AML shows the way.

Tenen DG.

Nat Rev Cancer. 2003 Feb;3(2):89-101. Review.

PMID:
12563308
[PubMed - indexed for MEDLINE]
20.

FLT3 mutations in acute myeloid leukemia cell lines.

Quentmeier H, Reinhardt J, Zaborski M, Drexler HG.

Leukemia. 2003 Jan;17(1):120-4.

PMID:
12529668
[PubMed - indexed for MEDLINE]

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