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Results: 1 to 20 of 30

1.

Inactivation of the PKR protein kinase and stimulation of mRNA translation by the cellular co-chaperone P58(IPK) does not require J domain function.

Yan W, Gale MJ Jr, Tan SL, Katze MG.

Biochemistry. 2002 Apr 16;41(15):4938-45.

PMID:
11939789
[PubMed - indexed for MEDLINE]
2.

Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress.

Ma K, Vattem KM, Wek RC.

J Biol Chem. 2002 May 24;277(21):18728-35. Epub 2002 Mar 20.

PMID:
11907036
[PubMed - indexed for MEDLINE]
Free Article
3.

The protein kinase/endoribonuclease IRE1alpha that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain.

Liu CY, Wong HN, Schauerte JA, Kaufman RJ.

J Biol Chem. 2002 May 24;277(21):18346-56. Epub 2002 Mar 15.

PMID:
11897784
[PubMed - indexed for MEDLINE]
Free Article
4.

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response.

Lee K, Tirasophon W, Shen X, Michalak M, Prywes R, Okada T, Yoshida H, Mori K, Kaufman RJ.

Genes Dev. 2002 Feb 15;16(4):452-66.

PMID:
11850408
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA.

Calfon M, Zeng H, Urano F, Till JH, Hubbard SR, Harding HP, Clark SG, Ron D.

Nature. 2002 Jan 3;415(6867):92-6. Erratum in: Nature 2002 Nov 14;420(6912):202.

PMID:
11780124
[PubMed - indexed for MEDLINE]
6.

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.

Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K.

Cell. 2001 Dec 28;107(7):881-91.

PMID:
11779464
[PubMed - indexed for MEDLINE]
Free Article
7.

Translational control is required for the unfolded protein response and in vivo glucose homeostasis.

Scheuner D, Song B, McEwen E, Liu C, Laybutt R, Gillespie P, Saunders T, Bonner-Weir S, Kaufman RJ.

Mol Cell. 2001 Jun;7(6):1165-76.

PMID:
11430820
[PubMed - indexed for MEDLINE]
Free Article
8.

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival.

Harding HP, Zeng H, Zhang Y, Jungries R, Chung P, Plesken H, Sabatini DD, Ron D.

Mol Cell. 2001 Jun;7(6):1153-63.

PMID:
11430819
[PubMed - indexed for MEDLINE]
Free Article
9.

Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha.

Novoa I, Zeng H, Harding HP, Ron D.

J Cell Biol. 2001 May 28;153(5):1011-22.

PMID:
11381086
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Regulated translation initiation controls stress-induced gene expression in mammalian cells.

Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M, Ron D.

Mol Cell. 2000 Nov;6(5):1099-108.

PMID:
11106749
[PubMed - indexed for MEDLINE]
Free Article
11.

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response.

Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D.

Nat Cell Biol. 2000 Jun;2(6):326-32.

PMID:
10854322
[PubMed - indexed for MEDLINE]
12.

Tissue specific expression of PKR protein kinase in aging B6D2F1 mice.

Ladiges W, Morton J, Blakely C, Gale M.

Mech Ageing Dev. 2000 Mar 13;114(2):123-32.

PMID:
10799709
[PubMed - indexed for MEDLINE]
14.

Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells.

Shi Y, An J, Liang J, Hayes SE, Sandusky GE, Stramm LE, Yang NN.

J Biol Chem. 1999 Feb 26;274(9):5723-30.

PMID:
10026192
[PubMed - indexed for MEDLINE]
Free Article
15.

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase.

Harding HP, Zhang Y, Ron D.

Nature. 1999 Jan 21;397(6716):271-4. Erratum in: Nature 1999 Mar 4;398(6722):90.

PMID:
9930704
[PubMed - indexed for MEDLINE]
16.

The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity.

Melville MW, Tan SL, Wambach M, Song J, Morimoto RI, Katze MG.

J Biol Chem. 1999 Feb 5;274(6):3797-803.

PMID:
9920933
[PubMed - indexed for MEDLINE]
Free Article
17.

Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors.

Yoshida H, Haze K, Yanagi H, Yura T, Mori K.

J Biol Chem. 1998 Dec 11;273(50):33741-9. Erratum in: J Biol Chem 1999 Jan 22;274(4):2592.

PMID:
9837962
[PubMed - indexed for MEDLINE]
Free Article
18.

Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control.

Shi Y, Vattem KM, Sood R, An J, Liang J, Stramm L, Wek RC.

Mol Cell Biol. 1998 Dec;18(12):7499-509.

PMID:
9819435
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

The molecular chaperone hsp40 regulates the activity of P58IPK, the cellular inhibitor of PKR.

Melville MW, Hansen WJ, Freeman BC, Welch WJ, Katze MG.

Proc Natl Acad Sci U S A. 1997 Jan 7;94(1):97-102.

PMID:
8990167
[PubMed - indexed for MEDLINE]
Free PMC Article

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