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Results: 1 to 20 of 32

1.

Inherited sodium channelopathies: novel therapeutic and proarrhythmic molecular mechanisms.

Balser JR.

Trends Cardiovasc Med. 2001 Aug;11(6):229-37. Review.

PMID:
11673053
[PubMed - indexed for MEDLINE]
2.

Gating-dependent mechanisms for flecainide action in SCN5A-linked arrhythmia syndromes.

Viswanathan PC, Bezzina CR, George AL Jr, Roden DM, Wilde AA, Balser JR.

Circulation. 2001 Sep 4;104(10):1200-5.

PMID:
11535580
[PubMed - indexed for MEDLINE]
Free Article
3.

Novel mechanism for Brugada syndrome: defective surface localization of an SCN5A mutant (R1432G).

Baroudi G, Pouliot V, Denjoy I, Guicheney P, Shrier A, Chahine M.

Circ Res. 2001 Jun 22;88(12):E78-83.

PMID:
11420310
[PubMed - indexed for MEDLINE]
Free Article
4.

A sodium-channel mutation causes isolated cardiac conduction disease.

Tan HL, Bink-Boelkens MT, Bezzina CR, Viswanathan PC, Beaufort-Krol GC, van Tintelen PJ, van den Berg MP, Wilde AA, Balser JR.

Nature. 2001 Feb 22;409(6823):1043-7.

PMID:
11234013
[PubMed - indexed for MEDLINE]
5.

Accelerated inactivation in a mutant Na(+) channel associated with idiopathic ventricular fibrillation.

Wan X, Chen S, Sadeghpour A, Wang Q, Kirsch GE.

Am J Physiol Heart Circ Physiol. 2001 Jan;280(1):H354-60.

PMID:
11123251
[PubMed - indexed for MEDLINE]
Free Article
6.

Contributions of charged residues in a cytoplasmic linking region to Na channel gating.

Miller JR, Patel MK, John JE, Mounsey JP, Moorman JR.

Biochim Biophys Acta. 2000 Dec 20;1509(1-2):275-91.

PMID:
11118539
[PubMed - indexed for MEDLINE]
Free Article
7.

Spectrum of ST-T-wave patterns and repolarization parameters in congenital long-QT syndrome: ECG findings identify genotypes.

Zhang L, Timothy KW, Vincent GM, Lehmann MH, Fox J, Giuli LC, Shen J, Splawski I, Priori SG, Compton SJ, Yanowitz F, Benhorin J, Moss AJ, Schwartz PJ, Robinson JL, Wang Q, Zareba W, Keating MT, Towbin JA, Napolitano C, Medina A.

Circulation. 2000 Dec 5;102(23):2849-55.

PMID:
11104743
[PubMed - indexed for MEDLINE]
Free Article
8.

Enhanced Na(+) channel intermediate inactivation in Brugada syndrome.

Wang DW, Makita N, Kitabatake A, Balser JR, George AL Jr.

Circ Res. 2000 Oct 13;87(8):E37-43.

PMID:
11029409
[PubMed - indexed for MEDLINE]
Free Article
9.

Functional suppression of sodium channels by beta(1)-subunits as a molecular mechanism of idiopathic ventricular fibrillation.

Wan X, Wang Q, Kirsch GE.

J Mol Cell Cardiol. 2000 Oct;32(10):1873-84.

PMID:
11013131
[PubMed - indexed for MEDLINE]
10.

The elusive link between LQT3 and Brugada syndrome: the role of flecainide challenge.

Priori SG, Napolitano C, Schwartz PJ, Bloise R, Crotti L, Ronchetti E.

Circulation. 2000 Aug 29;102(9):945-7.

PMID:
10961955
[PubMed - indexed for MEDLINE]
Free Article
11.

Two distinct congenital arrhythmias evoked by a multidysfunctional Na(+) channel.

Veldkamp MW, Viswanathan PC, Bezzina C, Baartscheer A, Wilde AA, Balser JR.

Circ Res. 2000 May 12;86(9):E91-7.

PMID:
10807877
[PubMed - indexed for MEDLINE]
Free Article
12.

A single Na(+) channel mutation causing both long-QT and Brugada syndromes.

Bezzina C, Veldkamp MW, van Den Berg MP, Postma AV, Rook MB, Viersma JW, van Langen IM, Tan-Sindhunata G, Bink-Boelkens MT, van Der Hout AH, Mannens MM, Wilde AA.

Circ Res. 1999 Dec 3-17;85(12):1206-13.

PMID:
10590249
[PubMed - indexed for MEDLINE]
Free Article
13.

Ionic mechanisms responsible for the electrocardiographic phenotype of the Brugada syndrome are temperature dependent.

Dumaine R, Towbin JA, Brugada P, Vatta M, Nesterenko DV, Nesterenko VV, Brugada J, Brugada R, Antzelevitch C.

Circ Res. 1999 Oct 29;85(9):803-9.

PMID:
10532948
[PubMed - indexed for MEDLINE]
Free Article
14.

Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation.

Yan GX, Antzelevitch C.

Circulation. 1999 Oct 12;100(15):1660-6.

PMID:
10517739
[PubMed - indexed for MEDLINE]
Free Article
15.

Sodium channel abnormalities are infrequent in patients with long QT syndrome: identification of two novel SCN5A mutations.

Wattanasirichaigoon D, Vesely MR, Duggal P, Levine JC, Blume ED, Wolff GS, Edwards SB, Beggs AH.

Am J Med Genet. 1999 Oct 29;86(5):470-6.

PMID:
10508990
[PubMed - indexed for MEDLINE]
16.

Cardiac conduction defects associate with mutations in SCN5A.

Schott JJ, Alshinawi C, Kyndt F, Probst V, Hoorntje TM, Hulsbeek M, Wilde AA, Escande D, Mannens MM, Le Marec H.

Nat Genet. 1999 Sep;23(1):20-1. No abstract available.

PMID:
10471492
[PubMed - indexed for MEDLINE]
17.

Solution structure of the sodium channel inactivation gate.

Rohl CA, Boeckman FA, Baker C, Scheuer T, Catterall WA, Klevit RE.

Biochemistry. 1999 Jan 19;38(3):855-61.

PMID:
9893979
[PubMed - indexed for MEDLINE]
18.

Multiple effects of KPQ deletion mutation on gating of human cardiac Na+ channels expressed in mammalian cells.

Chandra R, Starmer CF, Grant AO.

Am J Physiol. 1998 May;274(5 Pt 2):H1643-54.

PMID:
9612375
[PubMed - indexed for MEDLINE]
Free Article
19.

Genetic basis and molecular mechanism for idiopathic ventricular fibrillation.

Chen Q, Kirsch GE, Zhang D, Brugada R, Brugada J, Brugada P, Potenza D, Moya A, Borggrefe M, Breithardt G, Ortiz-Lopez R, Wang Z, Antzelevitch C, O'Brien RE, Schulze-Bahr E, Keating MT, Towbin JA, Wang Q.

Nature. 1998 Mar 19;392(6673):293-6.

PMID:
9521325
[PubMed - indexed for MEDLINE]
20.

Phenotypic characterization of a novel long-QT syndrome mutation (R1623Q) in the cardiac sodium channel.

Kambouris NG, Nuss HB, Johns DC, Tomaselli GF, Marban E, Balser JR.

Circulation. 1998 Feb 24;97(7):640-4.

PMID:
9495298
[PubMed - indexed for MEDLINE]
Free Article

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