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Regulation of translation initiation by FRAP/mTOR.

Gingras AC, Raught B, Sonenberg N.

Genes Dev. 2001 Apr 1;15(7):807-26. Review. No abstract available.


Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice.

Pende M, Kozma SC, Jaquet M, Oorschot V, Burcelin R, Le Marchand-Brustel Y, Klumperman J, Thorens B, Thomas G.

Nature. 2000 Dec 21-28;408(6815):994-7.


A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt.

Aoki M, Blazek E, Vogt PK.

Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):136-41.


Regulation of cellular growth by the Drosophila target of rapamycin dTOR.

Zhang H, Stallock JP, Ng JC, Reinhard C, Neufeld TP.

Genes Dev. 2000 Nov 1;14(21):2712-24.


Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin.

Oldham S, Montagne J, Radimerski T, Thomas G, Hafen E.

Genes Dev. 2000 Nov 1;14(21):2689-94.


TOR, a central controller of cell growth.

Schmelzle T, Hall MN.

Cell. 2000 Oct 13;103(2):253-62. Review.


The Pezcoller lecture: cancer cell cycles revisited.

Sherr CJ.

Cancer Res. 2000 Jul 15;60(14):3689-95. Review.


A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells.

Sekulić A, Hudson CC, Homme JL, Yin P, Otterness DM, Karnitz LM, Abraham RT.

Cancer Res. 2000 Jul 1;60(13):3504-13.


PIK3CA as an oncogene in cervical cancer.

Ma YY, Wei SJ, Lin YC, Lung JC, Chang TC, Whang-Peng J, Liu JM, Yang DM, Yang WK, Shen CY.

Oncogene. 2000 May 25;19(23):2739-44.


Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway.

Goberdhan DC, Paricio N, Goodman EC, Mlodzik M, Wilson C.

Genes Dev. 1999 Dec 15;13(24):3244-58.


Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity.

Ali IU, Schriml LM, Dean M.

J Natl Cancer Inst. 1999 Nov 17;91(22):1922-32. Review.


PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development.

Huang H, Potter CJ, Tao W, Li DM, Brogiolo W, Hafen E, Sun H, Xu T.

Development. 1999 Dec;126(23):5365-72.


Evidence for clonal outgrowth of androgen-independent prostate cancer cells from androgen-dependent tumors through a two-step process.

Craft N, Chhor C, Tran C, Belldegrun A, DeKernion J, Witte ON, Said J, Reiter RE, Sawyers CL.

Cancer Res. 1999 Oct 1;59(19):5030-6.


Drosophila S6 kinase: a regulator of cell size.

Montagne J, Stewart MJ, Stocker H, Hafen E, Kozma SC, Thomas G.

Science. 1999 Sep 24;285(5436):2126-9.


Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

Nakatani K, Thompson DA, Barthel A, Sakaue H, Liu W, Weigel RJ, Roth RA.

J Biol Chem. 1999 Jul 30;274(31):21528-32.


PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway.

Sun H, Lesche R, Li DM, Liliental J, Zhang H, Gao J, Gavrilova N, Mueller B, Liu X, Wu H.

Proc Natl Acad Sci U S A. 1999 May 25;96(11):6199-204.


The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway.

Wu X, Senechal K, Neshat MS, Whang YE, Sawyers CL.

Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15587-91.

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