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Items: 1 to 20 of 71

1.

High-Throughput and High-Content Screening for Huntington’s Disease Therapeutics.

Varma H, Lo DC, Stockwell BR.

In: Lo DC, Hughes RE, editors. Neurobiology of Huntington's Disease: Applications to Drug Discovery. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 5.

2.

Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicity.

Southwell AL, Khoshnan A, Dunn DE, Bugg CW, Lo DC, Patterson PH.

J Neurosci. 2008 Sep 3;28(36):9013-20. doi: 10.1523/JNEUROSCI.2747-08.2008.

3.
4.

Natural products as sources of new drugs over the last 25 years.

Newman DJ, Cragg GM.

J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. Review.

PMID:
17309302
5.

Alzheimer disease: amyloidogenesis, the presenilins and animal models.

Newman M, Musgrave IF, Lardelli M.

Biochim Biophys Acta. 2007 Mar;1772(3):285-97. Epub 2006 Dec 8. Review. Erratum in: Biochim Biophys Acta. 2007 Sep;1772(9):1118. Musgrave, F I [corrected to Musgrave, I F].

6.

Selective inhibitors of death in mutant huntingtin cells.

Varma H, Voisine C, DeMarco CT, Cattaneo E, Lo DC, Hart AC, Stockwell BR.

Nat Chem Biol. 2007 Feb;3(2):99-100. Epub 2006 Dec 31.

PMID:
17195849
7.

100 years and counting: prospects for defeating Alzheimer's disease.

Roberson ED, Mucke L.

Science. 2006 Nov 3;314(5800):781-4. Review.

8.

PGC-1alpha, a new therapeutic target in Huntington's disease?

McGill JK, Beal MF.

Cell. 2006 Nov 3;127(3):465-8. Review.

9.

A century-old debate on protein aggregation and neurodegeneration enters the clinic.

Lansbury PT, Lashuel HA.

Nature. 2006 Oct 19;443(7113):774-9. Review.

PMID:
17051203
10.

Screening for modulators of aggregation with a microplate elongation assay.

Berthelier V, Wetzel R.

Methods Enzymol. 2006;413:313-25.

PMID:
17046403
11.

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

Cui L, Jeong H, Borovecki F, Parkhurst CN, Tanese N, Krainc D.

Cell. 2006 Oct 6;127(1):59-69.

12.

High-throughput screening: update on practices and success.

Fox S, Farr-Jones S, Sopchak L, Boggs A, Nicely HW, Khoury R, Biros M.

J Biomol Screen. 2006 Oct;11(7):864-9. Epub 2006 Sep 14.

PMID:
16973922
13.

A clinical drug library screen identifies astemizole as an antimalarial agent.

Chong CR, Chen X, Shi L, Liu JO, Sullivan DJ Jr.

Nat Chem Biol. 2006 Aug;2(8):415-6. Epub 2006 Jul 2.

PMID:
16816845
14.

Cardiac glycosides provide neuroprotection against ischemic stroke: discovery by a brain slice-based compound screening platform.

Wang JK, Portbury S, Thomas MB, Barney S, Ricca DJ, Morris DL, Warner DS, Lo DC.

Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10461-6. Epub 2006 Jun 22.

15.

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.

Graham RK, Deng Y, Slow EJ, Haigh B, Bissada N, Lu G, Pearson J, Shehadeh J, Bertram L, Murphy Z, Warby SC, Doty CN, Roy S, Wellington CL, Leavitt BR, Raymond LA, Nicholson DW, Hayden MR.

Cell. 2006 Jun 16;125(6):1179-91.

16.

Biologically active molecules that reduce polyglutamine aggregation and toxicity.

Desai UA, Pallos J, Ma AA, Stockwell BR, Thompson LM, Marsh JL, Diamond MI.

Hum Mol Genet. 2006 Jul 1;15(13):2114-24. Epub 2006 May 23.

17.

A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen.

Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G, Piqani B, Eisenhaure TM, Luo B, Grenier JK, Carpenter AE, Foo SY, Stewart SA, Stockwell BR, Hacohen N, Hahn WC, Lander ES, Sabatini DM, Root DE.

Cell. 2006 Mar 24;124(6):1283-98.

18.

Minireview: ribonucleic acid interference for the identification of new targets for the treatment of metabolic diseases.

Rondinone CM.

Endocrinology. 2006 Jun;147(6):2650-6. Epub 2006 Mar 23. Review.

PMID:
16556759
19.

Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases.

Bodner RA, Outeiro TF, Altmann S, Maxwell MM, Cho SH, Hyman BT, McLean PJ, Young AB, Housman DE, Kazantsev AG.

Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4246-51. Epub 2006 Mar 6.

20.

Cannabinoid receptors as therapeutic targets.

Mackie K.

Annu Rev Pharmacol Toxicol. 2006;46:101-22. Review.

PMID:
16402900
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