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The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination.

Benvenuto G, Li S, Brown SJ, Braverman R, Vass WC, Cheadle JP, Halley DJ, Sampson JR, Wienecke R, DeClue JE.

Oncogene. 2000 Dec 14;19(54):6306-16.


The expression of hamartin, the product of the TSC1 gene, in normal human tissues and in TSC1- and TSC2-linked angiomyolipomas.

Plank TL, Logginidou H, Klein-Szanto A, Henske EP.

Mod Pathol. 1999 May;12(5):539-45.


Tuberin phosphorylation regulates its interaction with hamartin. Two proteins involved in tuberous sclerosis.

Aicher LD, Campbell JS, Yeung RS.

J Biol Chem. 2001 Jun 15;276(24):21017-21. Epub 2001 Apr 4.


Tuberous sclerosis as an underlying basis for infantile spasm.

Yeung RS.

Int Rev Neurobiol. 2002;49:315-32. Review.


The TSC1 gene product, hamartin, negatively regulates cell proliferation.

Miloloza A, Rosner M, Nellist M, Halley D, Bernaschek G, Hengstschläger M.

Hum Mol Genet. 2000 Jul 22;9(12):1721-7.


Evidence for separable functions of tuberous sclerosis gene products in mammalian cell cycle regulation.

Miloloza A, Kubista M, Rosner M, Hengstschläger M.

J Neuropathol Exp Neurol. 2002 Feb;61(2):154-63.


Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin.

Hodges AK, Li S, Maynard J, Parry L, Braverman R, Cheadle JP, DeClue JE, Sampson JR.

Hum Mol Genet. 2001 Dec 1;10(25):2899-905.


Multicompartmental distribution of the tuberous sclerosis gene products, hamartin and tuberin.

Yamamoto Y, Jones KA, Mak BC, Muehlenbachs A, Yeung RS.

Arch Biochem Biophys. 2002 Aug 15;404(2):210-7.


The tuberin-hamartin complex negatively regulates beta-catenin signaling activity.

Mak BC, Takemaru K, Kenerson HL, Moon RT, Yeung RS.

J Biol Chem. 2003 Feb 21;278(8):5947-51. Epub 2003 Jan 2.


Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products.

van Slegtenhorst M, Nellist M, Nagelkerken B, Cheadle J, Snell R, van den Ouweland A, Reuser A, Sampson J, Halley D, van der Sluijs P.

Hum Mol Genet. 1998 Jun;7(6):1053-7.


Hamartin and tuberin interaction with the G2/M cyclin-dependent kinase CDK1 and its regulatory cyclins A and B.

Catania MG, Mischel PS, Vinters HV.

J Neuropathol Exp Neurol. 2001 Jul;60(7):711-23.


Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B.

Astrinidis A, Senapedis W, Coleman TR, Henske EP.

J Biol Chem. 2003 Dec 19;278(51):51372-9. Epub 2003 Oct 9.


Developmental expression of the tuberous sclerosis proteins tuberin and hamartin.

Murthy V, Stemmer-Rachamimov AO, Haddad LA, Roy JE, Cutone AN, Beauchamp RL, Smith N, Louis DN, Ramesh V.

Acta Neuropathol. 2001 Mar;101(3):202-10.


Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex.

Murthy V, Han S, Beauchamp RL, Smith N, Haddad LA, Ito N, Ramesh V.

J Biol Chem. 2004 Jan 9;279(2):1351-8. Epub 2003 Oct 14.


Tuberous sclerosis in a 19-week fetus: immunohistochemical and molecular study of hamartin and tuberin.

Wei J, Li P, Chiriboga L, Mizuguchi M, Yee H, Miller DC, Greco MA.

Pediatr Dev Pathol. 2002 Sep-Oct;5(5):448-64. Epub 2002 Sep 4.


Loss of expression of tuberin and hamartin in tuberous sclerosis complex-associated but not in sporadic angiofibromas.

Fackler I, DeClue JE, Rust H, Vu PA, Kutzner H, Rütten A, Kaddu S, Sander CA, Volkenandt M, Johnson MW, Vinters HV, Wienecke R.

J Cutan Pathol. 2003 Mar;30(3):174-7.


The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton.

Haddad LA, Smith N, Bowser M, Niida Y, Murthy V, Gonzalez-Agosti C, Ramesh V.

J Biol Chem. 2002 Nov 15;277(46):44180-6. Epub 2002 Sep 10.


Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2.

Rosner M, Hengstschläger M.

J Biol Chem. 2004 Nov 19;279(47):48707-15. Epub 2004 Sep 8.


Tuberin and hamartin expression is reduced in the majority of subependymal giant cell astrocytomas in tuberous sclerosis complex consistent with a two-hit model of pathogenesis.

Jóźwiak S, Kwiatkowski D, Kotulska K, Larysz-Brysz M, Lewin-Kowalik J, Grajkowska W, Roszkowski M.

J Child Neurol. 2004 Feb;19(2):102-6.

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