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Results: 1 to 20 of 108

1.

The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease.

Huang S, Li B, Gray MD, Oshima J, Mian IS, Campisi J.

Nat Genet. 1998 Oct;20(2):114-6. No abstract available.

PMID:
9771700
[PubMed - indexed for MEDLINE]
2.

Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.

Shen JC, Gray MD, Oshima J, Kamath-Loeb AS, Fry M, Loeb LA.

J Biol Chem. 1998 Dec 18;273(51):34139-44.

PMID:
9852073
[PubMed - indexed for MEDLINE]
Free Article
3.

Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein.

Opresko PL, Laine JP, Brosh RM Jr, Seidman MM, Bohr VA.

J Biol Chem. 2001 Nov 30;276(48):44677-87. Epub 2001 Sep 25.

PMID:
11572872
[PubMed - indexed for MEDLINE]
Free Article
4.

WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair.

Chen L, Huang S, Lee L, Davalos A, Schiestl RH, Campisi J, Oshima J.

Aging Cell. 2003 Aug;2(4):191-9.

PMID:
12934712
[PubMed - indexed for MEDLINE]
5.

Werner syndrome helicase contains a 5'-->3' exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding.

Suzuki N, Shiratori M, Goto M, Furuichi Y.

Nucleic Acids Res. 1999 Jun 1;27(11):2361-8.

PMID:
10325426
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

The Werner syndrome protein: an update.

Oshima J.

Bioessays. 2000 Oct;22(10):894-901. Review.

PMID:
10984715
[PubMed - indexed for MEDLINE]
7.

The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro.

Orren DK, Theodore S, Machwe A.

Biochemistry. 2002 Nov 19;41(46):13483-8.

PMID:
12427008
[PubMed - indexed for MEDLINE]
8.

Nuclear DNA helicase II (RNA helicase A) interacts with Werner syndrome helicase and stimulates its exonuclease activity.

Friedemann J, Grosse F, Zhang S.

J Biol Chem. 2005 Sep 2;280(35):31303-13. Epub 2005 Jul 1.

PMID:
15995249
[PubMed - indexed for MEDLINE]
Free Article
9.

Characterization of the human and mouse WRN 3'-->5' exonuclease.

Huang S, Beresten S, Li B, Oshima J, Ellis NA, Campisi J.

Nucleic Acids Res. 2000 Jun 15;28(12):2396-405.

PMID:
10871373
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Quantitative analysis of Werner helicase activity using the single-molecule fluorescence detection system MF10S.

Futami K, Goto H, Shimamoto A, Watanabe T, Furuichi Y.

Biol Pharm Bull. 2005 Jan;28(1):9-12.

PMID:
15635154
[PubMed - indexed for MEDLINE]
Free Article
11.

Werner syndrome protein: biochemical properties and functional interactions.

Bohr VA, Cooper M, Orren D, Machwe A, Piotrowski J, Sommers J, Karmakar P, Brosh R.

Exp Gerontol. 2000 Sep;35(6-7):695-702. Review.

PMID:
11053659
[PubMed - indexed for MEDLINE]
12.

The Werner syndrome helicase-nuclease--one protein, many mysteries.

Fry M.

Sci Aging Knowledge Environ. 2002 Apr 3;2002(13):re2. Review.

PMID:
14602980
[PubMed - indexed for MEDLINE]
13.

Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex.

Li B, Comai L.

J Biol Chem. 2001 Mar 30;276(13):9896-902. Epub 2001 Jan 4.

PMID:
11152456
[PubMed - indexed for MEDLINE]
Free Article
14.

Characterisation of the interaction between WRN, the helicase/exonuclease defective in progeroid Werner's syndrome, and an essential replication factor, PCNA.

Rodríguez-López AM, Jackson DA, Nehlin JO, Iborra F, Warren AV, Cox LS.

Mech Ageing Dev. 2003 Feb;124(2):167-74.

PMID:
12633936
[PubMed - indexed for MEDLINE]
15.

Diverse dealings of the Werner helicase/nuclease.

Cheng WH, Bohr VA.

Sci Aging Knowledge Environ. 2003 Aug 6;2003(31):PE22.

PMID:
12904570
[PubMed - indexed for MEDLINE]
16.

Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells.

Futami K, Ishikawa Y, Goto M, Furuichi Y, Sugimoto M.

Cancer Sci. 2008 May;99(5):843-8. doi: 10.1111/j.1349-7006.2008.00778.x. Epub 2008 Feb 26. Review.

PMID:
18312465
[PubMed - indexed for MEDLINE]
17.

A minimal exonuclease domain of WRN forms a hexamer on DNA and possesses both 3'- 5' exonuclease and 5'-protruding strand endonuclease activities.

Xue Y, Ratcliff GC, Wang H, Davis-Searles PR, Gray MD, Erie DA, Redinbo MR.

Biochemistry. 2002 Mar 5;41(9):2901-12.

PMID:
11863428
[PubMed - indexed for MEDLINE]
18.

Unwinding the molecular basis of the Werner syndrome.

Shen J, Loeb LA.

Mech Ageing Dev. 2001 Jul 15;122(9):921-44. Review.

PMID:
11348659
[PubMed - indexed for MEDLINE]
19.

Lack of WRN results in extensive deletion at nonhomologous joining ends.

Oshima J, Huang S, Pae C, Campisi J, Schiestl RH.

Cancer Res. 2002 Jan 15;62(2):547-51.

PMID:
11809708
[PubMed - indexed for MEDLINE]
Free Article
20.

Competition between the DNA unwinding and strand pairing activities of the Werner and Bloom syndrome proteins.

Machwe A, Lozada EM, Xiao L, Orren DK.

BMC Mol Biol. 2006 Jan 13;7:1.

PMID:
16412221
[PubMed - indexed for MEDLINE]
Free PMC Article

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