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Results: 1 to 20 of 96

1.

Age-associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes--reversal with (R)-alpha-lipoic acid supplementation.

Lykkesfeldt J, Hagen TM, Vinarsky V, Ames BN.

FASEB J. 1998 Sep;12(12):1183-9.

PMID:
9737721
[PubMed - indexed for MEDLINE]
Free Article
2.

(R)-alpha-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo.

Hagen TM, Vinarsky V, Wehr CM, Ames BN.

Antioxid Redox Signal. 2000 Fall;2(3):473-83.

PMID:
11229361
[PubMed - indexed for MEDLINE]
3.

Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acid.

Suh JH, Shigeno ET, Morrow JD, Cox B, Rocha AE, Frei B, Hagen TM.

FASEB J. 2001 Mar;15(3):700-6.

PMID:
11259388
[PubMed - indexed for MEDLINE]
Free Article
4.

(R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate.

Hagen TM, Ingersoll RT, Lykkesfeldt J, Liu J, Wehr CM, Vinarsky V, Bartholomew JC, Ames AB.

FASEB J. 1999 Feb;13(2):411-8.

PMID:
9973329
[PubMed - indexed for MEDLINE]
Free Article
5.

Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress.

Hagen TM, Liu J, Lykkesfeldt J, Wehr CM, Ingersoll RT, Vinarsky V, Bartholomew JC, Ames BN.

Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1870-5. Erratum in: Proc Natl Acad Sci U S A 2002 May 14;99(10):7184.

PMID:
11854487
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid.

Hagen TM, Moreau R, Suh JH, Visioli F.

Ann N Y Acad Sci. 2002 Apr;959:491-507. Review.

PMID:
11976222
[PubMed - indexed for MEDLINE]
7.

Effect of DL-alpha-lipoic acid on mitochondrial enzymes in aged rats.

Arivazhagan P, Ramanathan K, Panneerselvam C.

Chem Biol Interact. 2001 Nov 28;138(2):189-98.

PMID:
11672700
[PubMed - indexed for MEDLINE]
8.

Relationship of the metabolism of vitamins C and E in cultured hepatocytes treated with tert-butyl hydroperoxide.

Glascott PA Jr, Gilfor E, Farber JL.

Mol Pharmacol. 1995 Jul;48(1):80-8.

PMID:
7623778
[PubMed - indexed for MEDLINE]
9.
10.

Ascorbic acid recycling in rat hepatocytes as measurement of antioxidant capacity: decline with age.

Lykkesfeldt J, Ames BN.

Methods Enzymol. 1999;299:83-8. No abstract available.

PMID:
9916199
[PubMed - indexed for MEDLINE]
11.

[Oxygen metabolism in isolated rat hepatocytes in obesity. Influence of vitamin C].

Drehmer E, Muñiz P, Valls V, Saez G, Cabo J.

Nutr Hosp. 1997 Sep-Oct;12(5):250-6. Spanish.

PMID:
9410088
[PubMed - indexed for MEDLINE]
12.

alpha-Lipoic acid dependent regeneration of ascorbic acid from dehydroascorbic acid in rat liver mitochondria.

Xu DP, Wells WW.

J Bioenerg Biomembr. 1996 Feb;28(1):77-85.

PMID:
8786242
[PubMed - indexed for MEDLINE]
13.

The antioxidant function of the physiological content of vitamin C.

Glascott PA Jr, Tsyganskaya M, Gilfor E, Zern MA, Farber JL.

Mol Pharmacol. 1996 Oct;50(4):994-9.

PMID:
8863846
[PubMed - indexed for MEDLINE]
14.

Combined efficacies of DL-alpha-lipoic acid and meso 2,3 dimercaptosuccinic acid against arsenic induced toxicity in antioxidant systems of rats.

Kokilavani V, Devi MA, Sivarajan K, Panneerselvam C.

Toxicol Lett. 2005 Dec 30;160(1):1-7. Epub 2005 Jul 5.

PMID:
15998567
[PubMed - indexed for MEDLINE]
15.

Alpha-lipoic acid protects against hepatic ischemia-reperfusion injury in rats.

Dulundu E, Ozel Y, Topaloglu U, Sehirli O, Ercan F, Gedik N, Sener G.

Pharmacology. 2007;79(3):163-70. Epub 2007 Jan 24.

PMID:
17259747
[PubMed - indexed for MEDLINE]
16.

Uptake, recycling, and antioxidant actions of alpha-lipoic acid in endothelial cells.

Jones W, Li X, Qu ZC, Perriott L, Whitesell RR, May JM.

Free Radic Biol Med. 2002 Jul 1;33(1):83-93.

PMID:
12086686
[PubMed - indexed for MEDLINE]
17.

Vascular oxidative stress and inflammation increase with age: ameliorating effects of alpha-lipoic acid supplementation.

Li L, Smith A, Hagen TM, Frei B.

Ann N Y Acad Sci. 2010 Aug;1203:151-9. doi: 10.1111/j.1749-6632.2010.05555.x.

PMID:
20716298
[PubMed - indexed for MEDLINE]
18.

The effects of ascorbic acid on free radical injury in cultured retinal pigment epithelial cells.

Woo KI, Lee J.

Korean J Ophthalmol. 1995 Jun;9(1):19-25.

PMID:
7674549
[PubMed - indexed for MEDLINE]
Free Article
19.

Hexosamine induction of oxidative stress, hypertrophy and laminin expression in renal mesangial cells: effect of the anti-oxidant alpha-lipoic acid.

Singh LP, Cheng DW, Kowluru R, Levi E, Jiang Y.

Cell Biochem Funct. 2007 Sep-Oct;25(5):537-50.

PMID:
16892452
[PubMed - indexed for MEDLINE]
20.

R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles.

Finlay LA, Michels AJ, Butler JA, Smith EJ, Monette JS, Moreau RF, Petersen SK, Frei B, Hagen TM.

Am J Physiol Regul Integr Comp Physiol. 2012 Mar 1;302(5):R587-97. doi: 10.1152/ajpregu.00393.2011. Epub 2011 Nov 2.

PMID:
22049228
[PubMed - indexed for MEDLINE]
Free PMC Article

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