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Huntingtin interacts with a family of WW domain proteins.

Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME.

Hum Mol Genet. 1998 Sep;7(9):1463-74.


Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis.

Passani LA, Bedford MT, Faber PW, McGinnis KM, Sharp AH, Gusella JF, Vonsattel JP, MacDonald ME.

Hum Mol Genet. 2000 Sep 1;9(14):2175-82.


Interaction of the nuclear matrix protein NAKAP with HypA and huntingtin: implications for nuclear toxicity in Huntington's disease pathogenesis.

Sayer JA, Manczak M, Akileswaran L, Reddy PH, Coghlan VM.

Neuromolecular Med. 2005;7(4):297-310.


Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins.

Huang CC, Faber PW, Persichetti F, Mittal V, Vonsattel JP, MacDonald ME, Gusella JF.

Somat Cell Mol Genet. 1998 Jul;24(4):217-33.


Huntingtin facilitates polycomb repressive complex 2.

Seong IS, Woda JM, Song JJ, Lloret A, Abeyrathne PD, Woo CJ, Gregory G, Lee JM, Wheeler VC, Walz T, Kingston RE, Gusella JF, Conlon RA, MacDonald ME.

Hum Mol Genet. 2010 Feb 15;19(4):573-83. doi: 10.1093/hmg/ddp524. Epub 2009 Nov 23.


Interaction with polyglutamine-expanded huntingtin alters cellular distribution and RNA processing of huntingtin yeast two-hybrid protein A (HYPA).

Jiang YJ, Che MX, Yuan JQ, Xie YY, Yan XZ, Hu HY.

J Biol Chem. 2011 Jul 15;286(28):25236-45. doi: 10.1074/jbc.M110.216333. Epub 2011 May 12.


PACSIN 1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brains.

Modregger J, DiProspero NA, Charles V, Tagle DA, Plomann M.

Hum Mol Genet. 2002 Oct 1;11(21):2547-58.


The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis.

Holbert S, Denghien I, Kiechle T, Rosenblatt A, Wellington C, Hayden MR, Margolis RL, Ross CA, Dausset J, Ferrante RJ, Néri C.

Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1811-6. Epub 2001 Jan 30.


Novel nuclear shuttle proteins, HDBP1 and HDBP2, bind to neuronal cell-specific cis-regulatory element in the promoter for the human Huntington's disease gene.

Tanaka K, Shouguchi-Miyata J, Miyamoto N, Ikeda JE.

J Biol Chem. 2004 Feb 20;279(8):7275-86. Epub 2003 Nov 18.


A human HAP1 homologue. Cloning, expression, and interaction with huntingtin.

Li SH, Hosseini SH, Gutekunst CA, Hersch SM, Ferrante RJ, Li XJ.

J Biol Chem. 1998 Jul 24;273(30):19220-7. Erratum in: J Biol Chem 1999 Apr 2;274(14):9906.


HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system.

Wanker EE, Rovira C, Scherzinger E, Hasenbank R, Wälter S, Tait D, Colicelli J, Lehrach H.

Hum Mol Genet. 1997 Mar;6(3):487-95.


HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain.

Kalchman MA, Koide HB, McCutcheon K, Graham RK, Nichol K, Nishiyama K, Kazemi-Esfarjani P, Lynn FC, Wellington C, Metzler M, Goldberg YP, Kanazawa I, Gietz RD, Hayden MR.

Nat Genet. 1997 May;16(1):44-53.


SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates.

Sittler A, Wälter S, Wedemeyer N, Hasenbank R, Scherzinger E, Eickhoff H, Bates GP, Lehrach H, Wanker EE.

Mol Cell. 1998 Oct;2(4):427-36.


Tissue transglutaminase selectively modifies proteins associated with truncated mutant huntingtin in intact cells.

Chun W, Lesort M, Tucholski J, Faber PW, MacDonald ME, Ross CA, Johnson GV.

Neurobiol Dis. 2001 Jun;8(3):391-404.


Mutant huntingtin forms in vivo complexes with distinct context-dependent conformations of the polyglutamine segment.

Persichetti F, Trettel F, Huang CC, Fraefel C, Timmers HT, Gusella JF, MacDonald ME.

Neurobiol Dis. 1999 Oct;6(5):364-75.


Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain.

Colomer V, Engelender S, Sharp AH, Duan K, Cooper JK, Lanahan A, Lyford G, Worley P, Ross CA.

Hum Mol Genet. 1997 Sep;6(9):1519-25.


Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice.

Wheeler VC, White JK, Gutekunst CA, Vrbanac V, Weaver M, Li XJ, Li SH, Yi H, Vonsattel JP, Gusella JF, Hersch S, Auerbach W, Joyner AL, MacDonald ME.

Hum Mol Genet. 2000 Mar 1;9(4):503-13.


Interaction of Huntington disease protein with transcriptional activator Sp1.

Li SH, Cheng AL, Zhou H, Lam S, Rao M, Li H, Li XJ.

Mol Cell Biol. 2002 Mar;22(5):1277-87.

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