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Items: 1 to 20 of 93

1.

Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers.

Veigl ML, Kasturi L, Olechnowicz J, Ma AH, Lutterbaugh JD, Periyasamy S, Li GM, Drummond J, Modrich PL, Sedwick WD, Markowitz SD.

Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8698-702.

2.

Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability.

Cunningham JM, Christensen ER, Tester DJ, Kim CY, Roche PC, Burgart LJ, Thibodeau SN.

Cancer Res. 1998 Aug 1;58(15):3455-60.

3.

Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability.

Fleisher AS, Esteller M, Wang S, Tamura G, Suzuki H, Yin J, Zou TT, Abraham JM, Kong D, Smolinski KN, Shi YQ, Rhyu MG, Powell SM, James SP, Wilson KT, Herman JG, Meltzer SJ.

Cancer Res. 1999 Mar 1;59(5):1090-5.

4.

Germline, somatic and epigenetic events underlying mismatch repair deficiency in colorectal and HNPCC-related cancers.

Yuen ST, Chan TL, Ho JW, Chan AS, Chung LP, Lam PW, Tse CW, Wyllie AH, Leung SY.

Oncogene. 2002 Oct 24;21(49):7585-92.

5.

Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1.

Fleisher AS, Esteller M, Harpaz N, Leytin A, Rashid A, Xu Y, Liang J, Stine OC, Yin J, Zou TT, Abraham JM, Kong D, Wilson KT, James SP, Herman JG, Meltzer SJ.

Cancer Res. 2000 Sep 1;60(17):4864-8.

6.

Alterations of DNA mismatch repair proteins and microsatellite instability levels in gastric cancer cell lines.

Yao Y, Tao H, Kim JJ, Burkhead B, Carloni E, Gasbarrini A, Sepulveda AR.

Lab Invest. 2004 Jul;84(7):915-22.

7.

Evaluation of microsatellite instability, hMLH1 expression and hMLH1 promoter hypermethylation in defining the MSI phenotype of colorectal cancer.

Arnold CN, Goel A, Compton C, Marcus V, Niedzwiecki D, Dowell JM, Wasserman L, Inoue T, Mayer RJ, Bertagnolli MM, Boland CR.

Cancer Biol Ther. 2004 Jan;3(1):73-8. Epub 2004 Jan 5.

PMID:
14726676
8.

High-resolution methylation analysis of the hMLH1 promoter in sporadic endometrial and colorectal carcinomas.

Strazzullo M, Cossu A, Baldinu P, Colombino M, Satta MP, Tanda F, De Bonis ML, Cerase A, D'Urso M, D'Esposito M, Palmieri G.

Cancer. 2003 Oct 1;98(7):1540-6.

9.

Mismatch repair gene expression defects contribute to microsatellite instability in ovarian carcinoma.

Geisler JP, Goodheart MJ, Sood AK, Holmes RJ, Hatterman-Zogg MA, Buller RE.

Cancer. 2003 Nov 15;98(10):2199-206.

10.

Extensive but hemiallelic methylation of the hMLH1 promoter region in early-onset sporadic colon cancers with microsatellite instability.

Miyakura Y, Sugano K, Akasu T, Yoshida T, Maekawa M, Saitoh S, Sasaki H, Nomizu T, Konishi F, Fujita S, Moriya Y, Nagai H.

Clin Gastroenterol Hepatol. 2004 Feb;2(2):147-56.

PMID:
15017620
11.

Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia.

Fleisher AS, Esteller M, Tamura G, Rashid A, Stine OC, Yin J, Zou TT, Abraham JM, Kong D, Nishizuka S, James SP, Wilson KT, Herman JG, Meltzer SJ.

Oncogene. 2001 Jan 18;20(3):329-35.

12.

Profile of methylated CpG sites of hMLH1 promoter in primary gastric carcinoma with microsatellite instability.

Kang GH, Lee S, Shim YH, Kim JC, Ro JY.

Pathol Int. 2002 Dec;52(12):764-8.

PMID:
12588445
13.

Methylation of hMLH1 in a population-based series of endometrial carcinomas.

Salvesen HB, MacDonald N, Ryan A, Iversen OE, Jacobs IJ, Akslen LA, Das S.

Clin Cancer Res. 2000 Sep;6(9):3607-13.

14.

MLH1 promoter methylation and gene silencing is the primary cause of microsatellite instability in sporadic endometrial cancers.

Simpkins SB, Bocker T, Swisher EM, Mutch DG, Gersell DJ, Kovatich AJ, Palazzo JP, Fishel R, Goodfellow PJ.

Hum Mol Genet. 1999 Apr;8(4):661-6.

15.
16.

Promoter hypermethylation and inactivation of hMLH1, a DNA mismatch repair gene, in head and neck squamous cell carcinoma.

Liu K, Zuo C, Luo QK, Suen JY, Hanna E, Fan CY.

Diagn Mol Pathol. 2003 Mar;12(1):50-6.

PMID:
12605036
17.

hMLH1 and hMSH2 expression in human hepatocellular carcinoma.

Wang L, Bani-Hani A, Montoya DP, Roche PC, Thibodeau SN, Burgart LJ, Roberts LR.

Int J Oncol. 2001 Sep;19(3):567-70.

PMID:
11494037
18.

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma.

Herman JG, Umar A, Polyak K, Graff JR, Ahuja N, Issa JP, Markowitz S, Willson JK, Hamilton SR, Kinzler KW, Kane MF, Kolodner RD, Vogelstein B, Kunkel TA, Baylin SB.

Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6870-5.

19.

Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status.

Oliveira C, Westra JL, Arango D, Ollikainen M, Domingo E, Ferreira A, Velho S, Niessen R, Lagerstedt K, Alhopuro P, Laiho P, Veiga I, Teixeira MR, Ligtenberg M, Kleibeuker JH, Sijmons RH, Plukker JT, Imai K, Lage P, Hamelin R, Albuquerque C, Schwartz S Jr, Lindblom A, Peltomaki P, Yamamoto H, Aaltonen LA, Seruca R, Hofstra RM.

Hum Mol Genet. 2004 Oct 1;13(19):2303-11. Epub 2004 Aug 4.

20.

High thymidylate synthase expression in colorectal cancer with microsatellite instability: implications for chemotherapeutic strategies.

Ricciardiello L, Ceccarelli C, Angiolini G, Pariali M, Chieco P, Paterini P, Biasco G, Martinelli GN, Roda E, Bazzoli F.

Clin Cancer Res. 2005 Jun 1;11(11):4234-40.

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