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Results: 1 to 20 of 380

1.

The 1.8 A crystal structure of the dimeric peroxisomal 3-ketoacyl-CoA thiolase of Saccharomyces cerevisiae: implications for substrate binding and reaction mechanism.

Mathieu M, Modis Y, Zeelen JP, Engel CK, Abagyan RA, Ahlberg A, Rasmussen B, Lamzin VS, Kunau WH, Wierenga RK.

J Mol Biol. 1997 Oct 31;273(3):714-28.

PMID:
9402066
[PubMed - indexed for MEDLINE]
2.

The 2.8 A crystal structure of peroxisomal 3-ketoacyl-CoA thiolase of Saccharomyces cerevisiae: a five-layered alpha beta alpha beta alpha structure constructed from two core domains of identical topology.

Mathieu M, Zeelen JP, Pauptit RA, Erdmann R, Kunau WH, Wierenga RK.

Structure. 1994 Sep 15;2(9):797-808.

PMID:
7812714
[PubMed - indexed for MEDLINE]
3.

Crystallographic analysis of the reaction pathway of Zoogloea ramigera biosynthetic thiolase.

Modis Y, Wierenga RK.

J Mol Biol. 2000 Apr 14;297(5):1171-82.

PMID:
10764581
[PubMed - indexed for MEDLINE]
4.

Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function.

Haapalainen AM, Meriläinen G, Pirilä PL, Kondo N, Fukao T, Wierenga RK.

Biochemistry. 2007 Apr 10;46(14):4305-21. Epub 2007 Mar 20.

PMID:
17371050
[PubMed - indexed for MEDLINE]
5.

High resolution crystal structures of human cytosolic thiolase (CT): a comparison of the active sites of human CT, bacterial thiolase, and bacterial KAS I.

Kursula P, Sikkilä H, Fukao T, Kondo N, Wierenga RK.

J Mol Biol. 2005 Mar 18;347(1):189-201. Epub 2005 Jan 19.

PMID:
15733928
[PubMed - indexed for MEDLINE]
6.

Genetic evaluation of physiological functions of thiolase isoenzymes in the n-alkalane-assimilating yeast Candida tropicalis.

Kanayama N, Ueda M, Atomi H, Tanaka A.

J Bacteriol. 1998 Feb;180(3):690-8.

PMID:
9457876
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

The crystal structure of a plant 3-ketoacyl-CoA thiolase reveals the potential for redox control of peroxisomal fatty acid beta-oxidation.

Sundaramoorthy R, Micossi E, Alphey MS, Germain V, Bryce JH, Smith SM, Leonard GA, Hunter WN.

J Mol Biol. 2006 Jun 2;359(2):347-57. Epub 2006 Mar 29.

PMID:
16630629
[PubMed - indexed for MEDLINE]
8.

The crystal structure of dienoyl-CoA isomerase at 1.5 A resolution reveals the importance of aspartate and glutamate sidechains for catalysis.

Modis Y, Filppula SA, Novikov DK, Norledge B, Hiltunen JK, Wierenga RK.

Structure. 1998 Aug 15;6(8):957-70.

PMID:
9739087
[PubMed - indexed for MEDLINE]
9.
10.

Mutagenesis of the amino targeting signal of Saccharomyces cerevisiae 3-ketoacyl-CoA thiolase reveals conserved amino acids required for import into peroxisomes in vivo.

Glover JR, Andrews DW, Subramani S, Rachubinski RA.

J Biol Chem. 1994 Mar 11;269(10):7558-63.

PMID:
8125978
[PubMed - indexed for MEDLINE]
Free Article
11.

Sterol carrier protein-2: structure reveals function.

Stolowich NJ, Petrescu AD, Huang H, Martin GG, Scott AI, Schroeder F.

Cell Mol Life Sci. 2002 Feb;59(2):193-212. Review.

PMID:
11915938
[PubMed - indexed for MEDLINE]
12.

The catalytic cycle of biosynthetic thiolase: a conformational journey of an acetyl group through four binding modes and two oxyanion holes.

Kursula P, Ojala J, Lambeir AM, Wierenga RK.

Biochemistry. 2002 Dec 31;41(52):15543-56.

PMID:
12501183
[PubMed - indexed for MEDLINE]
13.

The sulfur atoms of the substrate CoA and the catalytic cysteine are required for a productive mode of substrate binding in bacterial biosynthetic thiolase, a thioester-dependent enzyme.

Meriläinen G, Schmitz W, Wierenga RK, Kursula P.

FEBS J. 2008 Dec;275(24):6136-48. doi: 10.1111/j.1742-4658.2008.06737.x. Epub 2008 Nov 1.

PMID:
19016856
[PubMed - indexed for MEDLINE]
14.

The crystal structure of enoyl-CoA hydratase complexed with octanoyl-CoA reveals the structural adaptations required for binding of a long chain fatty acid-CoA molecule.

Engel CK, Kiema TR, Hiltunen JK, Wierenga RK.

J Mol Biol. 1998 Feb 6;275(5):847-59.

PMID:
9480773
[PubMed - indexed for MEDLINE]
15.

Crystal structure of beta-ketoacyl-acyl carrier protein synthase II from E.coli reveals the molecular architecture of condensing enzymes.

Huang W, Jia J, Edwards P, Dehesh K, Schneider G, Lindqvist Y.

EMBO J. 1998 Mar 2;17(5):1183-91.

PMID:
9482715
[PubMed - indexed for MEDLINE]
Free PMC Article
16.
17.

The 1.3 A crystal structure of human mitochondrial Delta3-Delta2-enoyl-CoA isomerase shows a novel mode of binding for the fatty acyl group.

Partanen ST, Novikov DK, Popov AN, Mursula AM, Hiltunen JK, Wierenga RK.

J Mol Biol. 2004 Sep 24;342(4):1197-208.

PMID:
15351645
[PubMed - indexed for MEDLINE]
18.

Crystal structure of enoyl-coenzyme A (CoA) hydratase at 2.5 angstroms resolution: a spiral fold defines the CoA-binding pocket.

Engel CK, Mathieu M, Zeelen JP, Hiltunen JK, Wierenga RK.

EMBO J. 1996 Oct 1;15(19):5135-45.

PMID:
8895557
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Crystal structure of rat short chain acyl-CoA dehydrogenase complexed with acetoacetyl-CoA: comparison with other acyl-CoA dehydrogenases.

Battaile KP, Molin-Case J, Paschke R, Wang M, Bennett D, Vockley J, Kim JJ.

J Biol Chem. 2002 Apr 5;277(14):12200-7. Epub 2002 Jan 25.

PMID:
11812788
[PubMed - indexed for MEDLINE]
Free Article
20.

Crystal structure of a pyrimidine dimer-specific excision repair enzyme from bacteriophage T4: refinement at 1.45 A and X-ray analysis of the three active site mutants.

Morikawa K, Ariyoshi M, Vassylyev DG, Matsumoto O, Katayanagi K, Ohtsuka E.

J Mol Biol. 1995 Jun 2;249(2):360-75.

PMID:
7783199
[PubMed - indexed for MEDLINE]

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