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Items: 1 to 20 of 144


The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis.

Xiao GH, Shoarinejad F, Jin F, Golemis EA, Yeung RS.

J Biol Chem. 1997 Mar 7;272(10):6097-100.


The GAP-related domain of tuberin, the product of the TSC2 gene, is a target for missense mutations in tuberous sclerosis.

Maheshwar MM, Cheadle JP, Jones AC, Myring J, Fryer AE, Harris PC, Sampson JR.

Hum Mol Genet. 1997 Oct;6(11):1991-6.


Suppression of tumorigenicity by the wild-type tuberous sclerosis 2 (Tsc2) gene and its C-terminal region.

Jin F, Wienecke R, Xiao GH, Maize JC Jr, DeClue JE, Yeung RS.

Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9154-9.


Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products.

van Slegtenhorst M, Nellist M, Nagelkerken B, Cheadle J, Snell R, van den Ouweland A, Reuser A, Sampson J, Halley D, van der Sluijs P.

Hum Mol Genet. 1998 Jun;7(6):1053-7.


Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells.

Uhlmann EJ, Apicelli AJ, Baldwin RL, Burke SP, Bajenaru ML, Onda H, Kwiatkowski D, Gutmann DH.

Oncogene. 2002 Jun 6;21(25):4050-9.


Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins.

Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA, Pan D.

Nat Cell Biol. 2003 Jun;5(6):578-81.


Multicompartmental distribution of the tuberous sclerosis gene products, hamartin and tuberin.

Yamamoto Y, Jones KA, Mak BC, Muehlenbachs A, Yeung RS.

Arch Biochem Biophys. 2002 Aug 15;404(2):210-7.


Tuberin phosphorylation regulates its interaction with hamartin. Two proteins involved in tuberous sclerosis.

Aicher LD, Campbell JS, Yeung RS.

J Biol Chem. 2001 Jun 15;276(24):21017-21. Epub 2001 Apr 4.


Localization of tuberous sclerosis 2 mRNA and its protein product tuberin in normal human brain and in cerebral lesions of patients with tuberous sclerosis.

Kerfoot C, Wienecke R, Menchine M, Emelin J, Maize JC Jr, Welsh CT, Norman MG, DeClue JE, Vinters HV.

Brain Pathol. 1996 Oct;6(4):367-75.


Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin.

Nellist M, van Slegtenhorst MA, Goedbloed M, van den Ouweland AM, Halley DJ, van der Sluijs P.

J Biol Chem. 1999 Dec 10;274(50):35647-52.


Comparative analysis and genomic structure of the tuberous sclerosis 2 (TSC2) gene in human and pufferfish.

Maheshwar MM, Sandford R, Nellist M, Cheadle JP, Sgotto B, Vaudin M, Sampson JR.

Hum Mol Genet. 1996 Jan;5(1):131-7. Erratum in: Hum Mol Genet. 1996 Apr;5(4):562.


Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration.

Astrinidis A, Cash TP, Hunter DS, Walker CL, Chernoff J, Henske EP.

Oncogene. 2002 Dec 5;21(55):8470-6.


The tuberin-hamartin complex negatively regulates beta-catenin signaling activity.

Mak BC, Takemaru K, Kenerson HL, Moon RT, Yeung RS.

J Biol Chem. 2003 Feb 21;278(8):5947-51. Epub 2003 Jan 2.


Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin.

Hodges AK, Li S, Maynard J, Parry L, Braverman R, Cheadle JP, DeClue JE, Sampson JR.

Hum Mol Genet. 2001 Dec 1;10(25):2899-905.


Evidence for separable functions of tuberous sclerosis gene products in mammalian cell cycle regulation.

Miloloza A, Kubista M, Rosner M, Hengstschläger M.

J Neuropathol Exp Neurol. 2002 Feb;61(2):154-63.


Expression of the tuberous sclerosis 2 gene product, tuberin, in adult and developing nervous system tissues.

Geist RT, Reddy AJ, Zhang J, Gutmann DH.

Neurobiol Dis. 1996 Apr;3(2):111-20.

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